Weiqiong Gu, M.D., Jiong Hu, M.D., Ph.D., Weiqing Wang, M.D., Lirong Li, M.D., Wei Tang, M.D., Shouyue Sun, M.D., Weijuan Cui, M.D., Lei Ye, M.D., Ph.D, Yifei Zhang, M.D., Ph.D., Jie Hong, M.D., Ph.D., Dalong Zhu, M.D., Guang Ning, M.D., Ph.D.

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Weiqiong Gu, M.D., Jiong Hu, M.D., Ph.D., Weiqing
Wang, M.D., Lirong Li, M.D., Wei Tang, M.D.,
Shouyue Sun, M.D., Weijuan Cui, M.D., Lei Ye,
M.D., Ph.D, Yifei Zhang, M.D., Ph.D., Jie Hong,
M.D., Ph.D., Dalong Zhu, M.D., Guang Ning, M.D.,
Ph.D.
Diabetes Care Volume 35 1413-1419 July, 2012
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Study Objectives
 

• To determine whether autologous nonmyeloablative
  hematopoietic stem cell transplantation (AHSCT)
  was beneficial for type 1 diabetic adolescents
  with diabetic ketoacidosis (DKA) at diagnosis

Gu W et al. Diabetes Care 2012351413-1419
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Study Design

• Enrolled 28 patients with type 1 diabetes, aged
  1430 years, in a prospective AHSCT phase II
  clinical trial
• HSCs harvested from peripheral blood after
  pretreatment consisting of cyclophosphamide and
  antithymocyte globulin
• Changes in the exogenous insulin requirement and
  serum levels of HbA1c, C-peptide, and
  anti-glutamic acid decarboxylase antibody
  measured before and after the AHSCT

Gu W et al. Diabetes Care 2012351413-1419
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Gu W et al. Diabetes Care 2012351413-1419
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Conclusions

• AHSCT appears to be an effective long-term
  treatment for insulin dependence that achieved a
  greater efficacy in patients without DKA at
  diagnosis

Gu W et al. Diabetes Care 2012351413-1419