Positive Symptoms of Schizophrenia

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Positive Symptoms of Schizophrenia
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Negative Symptoms of Schizophrenia
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Functional Status
100
50
0
15
20
40
60
Age in years
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DOPAMINE PATHWAYS
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mesolimbic overactivity positive symptoms of
psychosis
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Mesolimbic Dopaminergic Hyperactivity in
Schizophrenia
Laruelle et al., Ann NY Acad Sci (2003)
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Relationship Between Affinity for Dopamine D2
Receptors and Daily Dose for Treating
Schizophrenia
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primary dopamine deficiency
D2 receptor blockade
increase in negative symptoms
secondary dopamine deficiency
mesocortical pathway
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Hypofunction of Mesocortical Dopaminergic
Transmission in Schizophrenia
Laruelle et al., Ann NY Acad Sci (2003)
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Dopamine Dyregulation in Schizophrenia
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Glutamate-Dopamine Interactions in Schizophrenia
Takahata and Moghaddam, J Neurochem (2000)
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Kaplan and Hammer, Am Psychiatric Press Inc, 2002
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Thesis- Dopamine Dysregulation in Schizophrenia
Mechanism Schizophrenia Sxs 1.
Hypoactivity of PFC Negative/Cognitive DA
Systems Sxs 2. Hyperactivity of
NAc Positive Sxs DA Systems
3. Neuroleptic induced Improves
Positive Sxs DA blockade
Worsens Negative Sxs