H. U. MAY:

1
H. U. MAY Facts and hypotheses concerning the
causal or symptomatic therapeutic use of currents
in oncology - direct and indirect effects upon
cells, tissues and the whole organism. The
possibilities to optimize the efficacy of
currents by variation or fixation of their
parameters in dependence on the intended
therapeutic purpose.
2
Introduction concerning the history of
therapeutic use of currents for the treatment of
tumor patients
3
Already in the middle of the 18th century the two
German physicists HAUSEN WINKLER tried with
their electrical machine, based on friction, to
treat tumors. After the spreading of the
inventions of GALVANI (1737 - 1798) and VOLTA
(1745 - 1827) since the 19th century electricity
has been used more frequently to treat tumor
patients. Not only symptomatic treatments for
pain relief but even mainly causal treatments
consisting in trials to destroy the tumors were
usual.
4
In standard dictionaries and encyclopedias from
the second part of the 19th century and the first
decades of the 20th century you can find very
much more general information and special
description of the electrolytic destruction of
tumors by direct currents under the catchword
electrotherapy than in the second part of the
20th century and today.
5
Until today the galvanic current as the primarily
preferred current in the causal treatment of
tumor patients is used in various clinics and
hospitals, for instance in Austria according the
recommendations of PEKAR given in his 3 books
about the percutaneous galvanotherapy in cases of
tumors, published since 1988, basing on
experiences since 1977. Also in Sweden
NORDENSTRÖM used direct currents (DC) for the
treatment of tumors, basing on his theory of
biologically closed electric circuits (1983).
The DC method requires needles to be placed
inside the tumor. It is an invasive method. I
know, that in Germany, Denmark, Italy and China
in special hospitals this invasive DC method is
in use, however in Germany without public
advertising.
6
Just before the 1st world war VERAGUTH
SEYDERHELM (1913 and 1914, Zürich and Straßburg)
found the tendency of various direct and
alternating currents, applied as whole body
treatments in a 4 cell bath, to reduce the
number of white blood cells in leukemia patients.
The histories of RIFEs work in the United
States and independently from him of LAKHOVSKYs
work in France concerning cancer treatment using
alternating electrical fields of various
frequencies are well described in the RIFE
Report, written by Barry LYNES and published
1987, and in LAKHOVSKYs Secret of life,
published the first time 1929.
7
Tone frequency currents, a not very precise
term introduced by KOEPPEN 1935 in his paper
Tone frequency currents in medicine, has been
changed 1944 by the German physiologist
GILDEMEISTER in Leipzig into the term middle
frequency currents (MF), defined by the
frequency range between 1 kHz and ca. 100
kHz. GILDEMEISTER and his pupil SCHWARZ,
furthermore WYSS in Zürich, investigated the very
interesting and special advantageous
physiological properties of these MF currents,
however more from the standpoint of physiology
as a theoretical field of medicine than with a
practical therapeutic view. Consequently, they
did not take into account any thoughts concerning
the effects of MF upon tumors.
8
Without any knowledge about the publications
concerning MF currents published mainly in
journals of physiology the electronic engineer
Doctor NEMEC from Austria in the late 40s up to
1952 used MF currents between 4000 and 4100 Hz
for his invention of interferential current,
realized by the company NEMECTRON as the
Nemectrodyn machine.
9
Dr. Hanna FRESENIUS, a female general
practitioner in Steinau in Hessen (Germany) was
one of the first medical doctors, who experienced
the wide range of indications of the new
equipment including pain relief in cancer
patients. Additionally she observed in the
majority of the patients not only pain relief
but additionally a general increase of their
condition, of their quality of life, in some of
the patients even an inhibition of tumor growth
or a shrinking of the tumor.
10
After several years of successful treatments of
cancer patients with these interferential
currents other medical doctors, competitors which
were not familiar with the new treatment,
suggested a damning of the new electrotherapeutic
method in cancer patients by the regionally
responsible professional instance. Dr. Hanna
FRESENIUS was not agree. She moved with her
practice to Bavaria and pursued successfully to
treat cancer patients but more secretly.
11
Convinced by the beneficial effects of
interferential currents in cancer patients
Dr.Hanna FRESENIUS initiated animal experiments
together with the University of Freiburg. She fed
two groups of rats with the carcinogeneous
butter yellow (dimethylaminoazobenzol). One
group was treated nearly everyday with
interferential current. Only the animals of the
other group developed liver tumors. In this
time I was as a neurologist, physiologist and
pharmacologist with long experiences in
biomedical engineering and biocybernetics in the
University of Karlsruhe a member of the
medical-scientific research and development
department of Nemectron in Karlsruhe, responsible
for all theoretical and practical medical
questions.
12
(No Transcript)
13
With monetary, technical and scientific support
by Nemectron and with prepared rats from Prof.
Ferdinand SCHMIDT (Institute for Preventive
Oncology of the University Heidelberg-Mannheim)
Hanna FRESENIUS started new series in rats
suffering from chemically induced subcutaneous
tumors. When the tumors were detected early
enough and the diameter of the tumor was not
larger than 8 to 10 mm, the treatments with
interferential current (carrier frequencies
around 4000 Hz) leaded to a shrinking and finally
to a disappearance of the tumors
14
Larger tumors did not disappear. They sustained
to grow, partially up to the size of apples, and
the tumors seemed to cause intensive itch
sensations. The rats injured the skin in the
region of the subcutaneous tumor and finally the
tumor itself. The initially solid tumor had
changed to a cyst filled with a fluid. The cyst
opened by the teeth of the rat collapsed, was
infected, and the rat died within hours or few
days. These kinds of animal experiments could
not be continued because of a new law concerning
the use of animals for scientific research.
15
Therefore, with financial support by the German
Ministry for Research and Technology in the
laboratories of Nemectron and 4 institutes of
the medical faculties of various universities and
scientific centers (Freiburg, Aachen, German
Cancer Research Center Heidelberg, German Nuclear
Research Center Karlsruhe) investigations
concerning the influences of middle frequency
currents were carried out with normal and various
tumor cells. In 2 doctor dissertations (M.
NOSZVAI-NAGY, Karlsruhe, 1993/94, W. PETROW,
Aachen, 1988), in lectures and papers on a
symposium in Karlsruhe, 1990, and a German Cancer
Congress in Hamburg 1994 the results were
presented.
16

• The most important results were
• Some kinds of tumor cells in vitro can be
  killed during the application of middle
  frequency currents (with frequencies in the
  lower MF range, mainly 4000 Hz) they
  suddenly disappear by destruction of their
  cell membrane. Abnormal large cells appear
  to be more sensitive. However, not all types of
  the tumor cells had the same sensitivity.
  
• MF currents can facilitate the growth of normal
  fibroblasts in dependence on the strength
  of the electric field.

17

1. MF currents can influence the adenylcyclase
   resulting in changes of the intracellular cAMP
   formation, that means MF currents can have
   hormone-like effects. This corresponds with
   the results of other authors.
2. MF currents can cause an increase of the number
   and the size of mitochondria.
3. Alternating electric fields within the MF range
   facilitate and consequently accelerate the
   diffusion along the lines of the electric
   fields in the two opposite directions.
   This result was predictable due to physical,
   electrochemical and statistical
   considerations.

18
The cell culture research program supported by
the German government unfortunately could not be
continued because of monetary restrictions.
Additional psychological problems between the
supervisory board and the leading management of
Nemectron caused repetitive changes within the
top management team. Finally the owner of
Nemectron, the margrave of Baden, had to sale his
company. After few years the ownership changed
again.
19
My own experiences with interferential current
(MF between 4000 and 4100 Hz) as a neurologist
not an oncologist in tumor patients were
different. Some examples Tumor Result Astrocy
toma No success Glioblastoma No
success Chordoma Stop of the growth of the
tumor for many years, but not
destruction Patient was found dead in his bed
in the morning after a long evening of a
festival during his vacation in Spain.
20
Tumor Result Melanoma with metastases in the
central nervous system, earlier and larger in
the spinal cord resulting in paraplegia, Slowing
of growth later and smaller in the medulla
oblongata causing dizziness and circulatory
disturbances Not treatable In general
Significant pain relief, reduction of the
analgesic drugs, enhancement of the quality
of life, 6 months prolongation of the
survival time, life at home with his
family instead of an immediate death
under high dosages of narcotics at the
intensive care station of the
Dermatological department of the
University of Köln
21
Tumor Result The same patient suffered
since All the lipomas disappeared within his
early childhood from multiple few weeks after
the begin of the benignant tumors of the
fatty daily electrical treatments. tissue,
lipomas, disseminated to the whole body, rump
and limbs.
22
1981 THIESS DIETRICH in Heilbronn and 1994
KUKLINSKI in Rostock also reported conspicuous
beneficial however finally not healing effects in
tumor patients treated with interferential
currents. In KUKLINSKIs study a group of 37
patients received interferential current (IFC)
treatment twice per day. Modulation frequency was
scanned between 0.5 and 150 Hz. Results Partial
remissions were observed in patients with
superficial cutaneous metastases or ulcerative
mammary carcinomas (n3). Tumor progression was
lowered in 2 patients with pancreatic
carcinomas. Responses of tumors of the pulmonary
and bowel tracts were generally poor. In many
cases, a considerable reduction of
inconveniencies associated with the disease was
noted (e.g. reduction of pain, rapid improvement
of physical condition, etc.) Conclusion In order
to improve the response of malignant tumors,
particularly of deep-lying tumors, hitherto
existing parameters and strategies of
IFC-treatment seem to require revision.
23
Taking into account the fact that in cell
culture experiments and in patients the desired
effects of MF currents seemed to be dependent
on the type of the tumor, the question
arose Is the sensitivity of the special type
of tumor cells dependent on the frequency of the
MF current?
24
This was the origin of my idea to use the
modulation of the frequency in a mathematically
continual way over a wide range in accordance
with the technical and legitimate possibilities,
avoiding arbitrary irregular and to large steps
and to minimize the differences between the
theoretically optimum frequency and the really
generated frequency.
25
Additionally,the electrical, neurophysiologic
and psychophysical possibilities concerning the
intensities of the applied frequency-dependent
currents should be optimized. The distance to
local and systemic tolerance limits should be as
large as possible to maximize the therapeutic
width.
26
Since 2000 my idea of simultaneous modulation
of frequency and amplitude (SimulFAM)
adaptable tothe individual and local
frequency-dependent threshold of sensation is
realized and available until now in Europe and
Asia as HiToP, High Tone Power Therapy (MAY,
2002 and 2004).
27
The manufacturer is the company gbo, Gerätebau
Odenwald, in Rimbach, manufacturing and
distributing too still traditional low-frequency
and interferential electrotherapy units of
Siemens. The frequency is modulated in quarter
tone steps between 4096 and 32768 Hz. With 73
frequencies (tones in the high tone and low
ultrasound ranges) 3 octaves are covered. The
maximum distance to a theoretically optimum
frequency or to a frequency in an harmonic
relation to this optimum frequency is 1/8 tone
step.
28
Facts and hypothesesconcerning the causal or
symptomatic therapeutic use of currents in
oncology direct and indirect effects upon
cells, tissues and the whole organism
29
Causal therapeutic use Facts Some facts as
results of experimental studies are already
itemized in the introduction under number 1 5.
30
Hypotheses regarding inhibitory effects of
un-modulated, amplitude-modulated and
simultaneously frequency- and amplitude-modulated
middle frequency currents upon tumor
growth Direct effects of currents upon
transformed cells Changes and renormalizations
of pathological processes in tumor cells, caused
by stimulatory and multi-facilitatory
(electro-biochemical, non-stimulatory)
effects induced by electrically triggered
molecular conformation changes within the cell
membrane, that means a kind of simulation of
hormone effects, resulting in the (normalization
of) formation of intracellular second messengers,
for example cyclic AMP
31
induced by capacitively coupled effectsthrough
the cell membrane into the intracellular space
(cytosol),through the outer mitochondrial
membrane into the intermembrane space
andthrough the inner mitochondrial membrane
into the mitochondrial matrix,for
instance multi-facilitatory effects upon the
metabolism facilitation of diffusion
processes facilitation of enzymatically mediated
processes of the intracellular metabolism
32
facilitation of enzymatically mediated processes
of the intracellular metabolism, basing onthe
increase of the kinetic energy of molecules
involved in metabolic processes, lowering the
differences to the required activation
energy,the increase of the probability of the
events of the important accidental meetings
between enzyme and substrate,the increase of
the probability of the events of the important
accidental meetings between enzyme and substrate
in the correct position (according to DAFFORN
KOSHLANDA. DAFFORN D. E. KOSHLAND jr.,
Biochem. Biophys. Res. Commun. 52, 780, (1973) )
33
direct influences upon the transport mechanisms
of protons and electrons within the inner
membrane of the mitochondria preference of the
aerobic metabolic pathways instead of the
anaerobic glycolysis
34
induced by direct influence upon
theintercellular communication ("cleaning
effect" concerning ion channels including gap
junctions), resulting in partial or total
recovery of the disturbed electrical and
chemical communication between tumor cells
mutually and between tumor cells and the cells in
the adjacent tissue (one step to a
redifferentiation) partial or total recovery of
the disturbed metabolic cooperation between
tumor cells mutually and between tumor cells and
the cells in the adjacent tissue (a second step
to a redifferentiation) partial or total
recovery of the disturbed functional
coordination between tumor cells mutually and
between tumor cells and the cells in the adjacent
tissue (a third step to a redifferentiation)
35
partial or total recovery of the disturbed
probably electrically mediated control of the
target of the normal topographic-anatomical and
histological structure of the referred body
region (last step and desired main goal of
redifferentiation)
36
Over-stress of the pathologically changed
metabolism of the tumor cell, caused by
frequently generated depolarization and the
required repolarisation (stimulatory effect,
possible with supra-threshold intensities only)
37
Indirect effects Primary effects Activation of
cells of the immune system by means of sustained
depolarization (non-stimulatory effect) of the
involved cells of the immune system, causing an
increase of cell division rates of normal cells
which are able to increase their mitotic activity
if such increase is required, by means of
cyclic AMP formation (non-stimulatory
multi-facilitatory and stimulatory effect)
within the involved cells of the immune
system, by facilitation of intercellular
communication (non-stimulatory multi-facilitatory
effect)
38
by an increase of generation of natural killer
cells (NKC),observed by KUKLINSKI as a result of
stimulatory effects, probably possible with
non-stimulating currents too.
39
Enhancement of the efficacy of the activity of
the cells of the immune system in the
neighborhood of the tumor by means of the
equilibration effect upon concentration
differences normalizing the pH values.Due to
the preference of the anaerobic metabolism in
tumor cells with an increase of lactic acid
production the pH is lowered in the extracellular
space within the tumor and in its neighborhood
the lowered pH is impairing the function of the
cells of the immune system.
40
Partial or total recovery of the disturbed
communication between the asocial cells of the
tumor takes place by means of the electrochemical
shaking effect. Stimulation of the sympathetic
nervous system (by stimulatory effects) orelease
of transmitters (mainly nor-epinephrine) from
the varicosities of the sympathetic nerve endings
oreduction of inflammatory tissue changes in
the neighborhood of the tumor o activation of
receptors within the cell membranes involved in
the tumor growth inhibiting processes
41
Secondary effects The activation of cells of
the immune system could result in the following
secondary effects Increase of
phagocytosisIncrease of the release of
mediators acting as inhibitors of tumor growth
or even as tumor cell destroying agents (for
instance tumor necrosis factor)
42

• Symptomatic therapeutic use
• The symptomatic therapeutic use concerns mainly
• 1. pain relief
• edema reduction
• prevention of venous thromboses
• 4. reduction of the required dosage of pain
  relieving and other drugs with reduction of
  their side effects
• 5. inhibition of cachexia by b-mimetic effects
• 6. general enhancement of the quality of life

43
The possibilities to optimize the efficacy of
currents by variation or fixation of their
parameters in dependence on the intended
therapeutic purpose Pain reliefFive pain
relieving effects are available
1. Distribution and thinning of mediators of
pain and inflammation 2. Real
nerve block by reversible sustained partial
depolarization, plateau effect
3. Pseudo block associated with tea,
transient excitatory activity
4. Counter-irritation (GAMMON STARR, 1941)
and b -endorphin release 5.
In cases of painful swellings indirect causal
pain relief by edema reduction
44
The following parameters should be preferred1.
High intensities during blocks with higher fixed
frequencies (max. 32768 Hz) or
SimulFAM along the threshold curve, SimulFAMi2.
Maximum tolerable intensity with higher fixed
frequencies (max. 32768 Hz)3. High
intensity with higher fixed frequencies (max.
32768 Hz)4. SimulFAMX with crossing of the
threshold curve, frequency of modulation
100 Hz5. SimulFAMX with crossing of the
threshold curve, frequency of modulation 10
Hz
45
2. Edema reduction (in general) and prevention
of venous thrombosesa. caused by stimulation
of sympathetic fibersb. (in lower legs an
feet) caused by activation of the muscle
pumpc. caused by reversible sustained partial
depolarization of the smooth muscles of the
lymphatic vessels and the blood vessels,
plateau effectThe following parameters should
be preferreda. SimulFAMX with crossing of the
threshold curve, frequency of modulation 10
Hzb. SimulFAMX with crossing of the threshold
curve, frequency of modulation 0.3 Hzc.
High intensity with higher fixed frequencies
(max. 32768Hz)
46
3. - 5.The therapeutically desired
effects mentioned above concerning reduction
of drugs and their side effects, inhibition of
cachexia andgeneral enhancement of the quality
of life are present in all cases of
parameter selection. They do not require
special parameters.
47
Selected Literature dARSONVAL, A. Action
physiologique des courants alternatifs. C. R.
Soc. Biol. Paris 43, 453 (1891) dARSONVAL,
A. Recherches d électrothérapie. La
voltaisation sinusoidale. Arch. Physiol. norm.
pathol. 24, 69 (1892) dARSONVAL, A. Effects
physiologiques de la voltaisation
sinusoidale. Arch. Physiol. norm. pathol. 25, 387
391 (1893) dARSONVAL, A. Action
physiologique des courants alternatitifs à grande
fréquence. Arch. Physiol. norm. pathol. 25, 401
408 (1893)
48
dARSONVAL, A. Production des courants de haute
fréquence et de grande intensité leurs effects
physiologiques. Comptes Rendus de séances et
memoires de la. Société de Biologie et de ses
filiales. Paris 45, 122 - 124 (1893) dARSONVAL,
A. Influence de la fréquence sur les effect
physiologiques des courants alternatifs. Lindustr
ie électrique 2, 168 - 169 (1893) dARSONVAL,
A. Action physiologique et thérapeutique des
courants à haute fréquence. Ann. Electrobiol. 1,
1 (1898)
49
BOWMAN, B. R. Electrical block of peripheral
motor activity. A dissertation submitted to the
Faculty of Electrical Engineering Edvard Kardelj
University of Ljubljana, Yugoslavia In partial
fulfilment of the requirements for the degree
Doctor of Science (Electrical Engineering) May
1981 Conducted at Rancho Los Amigos
Rehabilitation Engineering Center, Rancho Los
Amigos Hospital, Downey, California BRIGHTON, C.
T., P. F. TOWNSEND Increased cAMP production
after short term capacitively coupled stimulation
of bovine growth plate chondrocytes. Transactions
of the 6th annual meeting of the Bioelectrical
Repair and Growth Society (BRAGS), vol.VI, p. 43,
Oct. 19th 22nd 1986
50
BROMM, B., H. LULLIES Über den Mechanismus der
Reizwirkung mittelfrequenter Wechselströme auf
die Nervenmembran. Pflügers Arch. 289, 215 226
(1966) CLARK, H. R. The cure of all cancers San
Diego, CA, USA New Century Press 1993 CLARK, H.
R. The cure for all diseases San Diego, CA, USA
New Century Press 1995
51
CONE, C. D, Jr. Control of cell division by the
electrical voltage of the surface
membrane Molecular Biophysics Laboratory, Langley
Research Center, National Aeronautics and Space
Administration, Hampton, Virginia
23365 Presentation to The 12th Annual Science
Writers Seminar, San Antonio, Texas, March 20-25
1970 , American Cancer Society CONE, C. D,
Jr. Unified theory on the basic mechanism of
normal mitotic control and oncogenesis. J. theor.
Biol. 30, 151 181 (1971)
52
CONE, C. D., Jr. The role of the surface
electrical transmembrane potential in normal and
malignant mitogenesis. Annals of the New York
Academy of Sciences 238, 420 435 (1974) CONE,
C. D. Jr., C. M. CONE Induction of mitosis in
mature neurons in central nervous system by
sustained depolarization. Science 192, 155 - 157
(1976) CONE, C. D. Jr. M. TONGIER Contact
inhibition of division Involvement of the
electrical transmembrane potential. Cell
Pysiology 82, 373 386 (1973) DAFFORN, A. D.
E. KOSHLAND jr.Biochem. Biophys. Res. Commun.
52, 780, (1973)
53
DALZIEL, C. F. Electric shock. Advances in
Biomed. Engineering 3, 223 248 (1973) DALZIEL,
C. F. Dangerous electric currents AIEE
Transactions 65, 579 584 (1946) DALZIEL, C.
F. The threshold of perception currents. AIEE
Transactions 73, 990 995 (1954) DALZIEL, C.
F., J. B. LAGEN J. L. THURSTON Electric
shock AIEE Transactions 60, 1073 1078 (1941)
54
DALZIEL, C. F., E. OGDEN C. E. ABBOTT Effect
of frequency on let-go currents. AIEE
Transactions 62, 745 749 (1943) DUDEK,
J. Terapia energotonowa. Ogólnopolski Przeglad
Medyczny (OPM) 11/2002, 22 Katowice Elamed
Wydawnictwo 2002 EHMEN,G. Diffusionsbeeinflussun
g im Knochengewebe durch Interferenzstromverfahren
. Diplomarbeit, Fachhochschule Wilhelmshaven, 1990
55
FRESENIUS, Hanna Krebsfürsorge (Letter to th
editors) Selecta 22, 329 331 (1980) (Heft 4,
28. Jan. 1980) FRESENIUS, Hanna Niederfrequenter
Interferenzstrom gegen maligne
Entartung Ärztliche Praxis 37, 2529
(1985) FRESENIUS, Hanna Was das Leben lebendig
macht. Erzählungen aus Steinau an der Straße pp.
266 269 Experiences with interferential
therapy in cancer patients. Marquartstein,
Bavaria, Germany Th. Breit 1986
56
GAMMON, G. D., I. STARR Studies on the relief
of pain by counter-irritation. J. clin. Invest.
20, 13 21 (1941) GEDDES, L. A., L. E. BAKER,
A. G. MOORE T. W. COULTER Hazards in the use
of low frequencies for the measurement of
physiological events by impedance. Med. biol.
Engineering 7, 289 296 (1969) GILDEMEISTER,
M. Untersuchungen über die Wirkung von
Mittelfrequenzströmen auf den Menschen. Pflügers
Arch. 247, 366 404 (1944) GREEN, R. T. The
absolute threshold of electric shock. Brit. J.
Psychol. 53, 107 115 (1962)
57
HANSJÜRGENS, A., H. U. MAY Elektrische
Differentialtherapie - EDiT Karlsruhe Nemectron
1990 HAUSER-TILLMANN, Hildegard Dr. med., M. D.,
Frauenärztin, Gynecologist, in D -88677 Markdorf,
Gutenbergstr. 1a) Personal communication
Arzt-Bericht vom 21. Oktober 1997 über eine von
März bis September 1997 durchgeführte
erfolgreiche Hochton-Behandlung einer Patientin
mit Gallensteinen und häufigen Koliken. Clinical
report, dated from October 21st 1997 concerning a
successful high tone therapy treatment of a
female patient with gall-stones and frequent
bilious colics over a period of seven months
(March September 1997) HÖNES, R. D. Der
Einfluß von Interferenzstrom auf das
Wachstumsverhalten von Zellkulturen. Inauguraldiss
ertation. Freiburg i. Br. 1983
58
HUMPERT, P. M., G. RUDOFSKY, M. MORCOS, A.
BIERHAUS P. P. NAWROTH Hochtontherapie zu
Behandlung schmerzhafter Neuropathie bei Typ 2
Diabetikern verbessert die mikrovaskuläre
Endothelzellfunktion High tone therapy for the
treatment of painful neuropathy in type 2
diabetic patients improves the microvascular
endothelial function. Poster and Abstract. 41.
Jahrestagung der Deutschen Diabetes-Gesellschaft,
Leipzig, 24. 27. Mai 2006, Diabetologie und
Stoffwechsel 2006, DOI 10.1055/s-2006-94 JAMAKOS
MANOVIC, A., W. LOEWENSTEIN. Intercellular
communication and tissue growth III. Thyreoid
cancer. J. Cell Biology 38, 556 - 561 (1968)
59
JOOS, U., H. U. MAY C. MITTERMAYER
Stimulation of fibroblast proliferation by means
of electrical current. 8th Int. Conf. Oral Surg.,
Berlin, June 25 30, 1983 KEILHOLZ, L., U.
RANDOLL, R. SAUER E. STEINHÄUSER Supportive
interferential current therapy in the treatment
of advanced head and neck tumors. 21. Deutscher
Krebskongreß, Hamburg, 7.-11. März 1994 21th
National Cancer Congress of the German Cancer
Society Supplement to Journal of Cancer Research
and Clinical Oncology Vol. 120, 05.09.03
(1994) KNEDLITSCHEK, G., K. F. WEIBEZAHN H.
DERTINGER Zelluläre Wirkungen des
Interferenzstromes 21. Deutscher Krebskongreß,
Hamburg, 7.-11. März 1994 21th National Cancer
Congress of the German Cancer Society Supplement
to Journal of Cancer Research and Clinical
Oncology Vol. 120, 05.09.02 (1994)
60
KOEPPEN, S. Über die Anwendung von
Tonfrequenzströmen in der Medizin. Verhandlungen
der Deutschen Gesellschaft für innere Medizin,
München, 47, 458 460 (1935) KOMITOWSKI, D.,
V. EHEMANN Der Einfluß von elektrischen
Mittelfequenz-Wechselfeldern auf normale
Fibroblasten, normale und transformierte
Hepatocyten sowie normale Nierenepithelzellen des
Rattenkänguruhs. The influence of alternating
middle-frequency electric fields upon
fibroblasts, normal and transformed hepatocytes
and normal epithelial kidney cells of the rat
kangaroo Vorträge, gehalten über am Deutschen
Krebsforschungszentrum in Heidelberg
durchgeführte Untersuchungen auf einem Symposion
zum Thema Tumoren und Ströme am 16. Mai 1990 in
Karlsruhe Lectures about the results of a study
carried out in the German Cancer Research Center
Heidelberg, presented during a Symposion Tumors
and Currents in Karlsruhe, Germany, May 16th 1990
61
KORENSTEIN, R., D. SOMJEN, H. FISCHLER I.
BINDERMAN Capacitively pulsed electric
stimulation of bone cells. Induction of
cyclic-AMP changes and DNA synthesis. Biochimica
et Biophysica Acta 803, 302 307 (1984),
Elsevier Science Publishers LAABS, W. A., E.
MAY, K. D. RICHTER, H. J. HÖHLING, J. ALTHOFF,
P. QUINT A. HANSJÜRGENS Knochenheilung und
dynamischer Interferenzstrom (DIC) Erste
vergleichende tierexperimentelle Studie an
Schafen. Teil I Experimentelles Vorgehen und
histologische Ergebnisse. Teil II Physikalische
und chemische Ergebnisse. Langenbecks Arch. Chir.
356, 219 229 u. 231 241 (1982) LANGMAN, L.,
H. S. BURR A technique to aid in the detection
of malignancy of the female genitale tract. Am.
J. Obst. Gynec 57, 274 281 (1949)
62
LOEWENSTEIN, W. Permeability of membrane
junctions In Conferenc on biological membranes
recent Progress. Annales New York Academy of
Sciences 137, 441 472 (1966)LOEWENSTEIN, W.,
Y. KANNO Intercellular communication and the
control of tissue growth Lack of communication
between cancer cells Nature 209, 1248 1249
(1966) LOEWENSTEIN, W., Y. KANNO Intercellular
communication and tissue growth I. Cancerous
growth. J. Cell Biology 33, 225 234
(1967) LOEWENSTEIN, W., R. D.
PENN Intercellular communication and tissue
growth II. Tissue regeneration. J. Cell Biology
33, 235 - 242 (1967)
63
JAMAKOSMANOVIC, A., W. LOEWENSTEIN. Intercellul
ar communication and tissue growth III. Thyreoid
cancer. J. Cell Biology 38, 556 - 561
(1968) JOOS, U., H. U. MAY Ch.
MITTERMAYER Stimulation of Fibroblast
proliferation by mean of electrical
current Presentation (Poster) to the 8th
International Conference on Oral Surgery,
Berlin, 25-30 June 1983 KUKLINSKI,
B. Interferential current therapy of tumors
Preliminary results 21. Deutscher Krebskongreß,
Hamburg, 7.-11. März 1994 21th National Cancer
Congress of the German Cancer Society Supplement
to Journal of Cancer Research and Clinical
Oncology Vol. 120, 05.09.05 (1994) LAKHOVSKY,
Georges The secret of life. London, 152, Landor
road, Stockwell, S.W.9. 1951
64
LYNES, B. The cancer cure that worked! Fifty
years of suppression. The RIFE report. Queensville
, Ontario, Canada, Marcus Books, 1st printing
March 1987, 6th pr. October 1997 MAY, H. U.
Simultaneous modulation of frequency and
amplitude of middle frequency currents between
high tone and low ultrasound range applied
physiology for differentiated electrotherapy
concerning the distinction and specific
proportional mixture of stimulatory and
non-stimulatory (metabolic and/or blocking)
effects. In Abstracts of the Joint Meeting of
The Physiological Society, Scandinavian
Physiological Society and Deutsche
Physiologische Gesellschaft (81st Annual
Meeting) 15-19 March 2002, Tübingen, Germany
Europ. J. Physiol. 443, Suppl., (P 53-9) 363
(2002)
65
MAY, H. U. Extremely comfortable trancutaneous
electrical stimulation of nerves including
motor and sympathetic fibres by simultaneous
modulation of frequency and amplitude of middle
frequency currents. In Abstracts of the 83rd
Annual Meeting Deutsche Physiologische
Gesellschaft 14-17 March 2004, Leipzig,
Germany Europ. J. Physiol. 447, Suppl.1, (P
35-11) S156 (2004) MAY, H. U. High Tone
Frequency Power Therapy with HiToP in general
and particularly in cases of painful conditions
of the musculo-skeletal system in special
consideration of low back pain, including a part
of the results of a clinical study carried out
and evaluated by E. RHADES B. SCHNEIDER Paper
presented at the 4th Annual International
Congress of Egyptian Society of Back Pain, Cairo,
Egypt, 16 - 17 April 2004
66
MAY, H. U. High Tone Power Therapy Scientific
development to optimise the physical,
physiological and therapeutic effects of middle
frequency currents Paper presented at the 6th
Annual International Congress of Egyptian Society
of Back Pain, Cairo, Egypt, 19 20 April
2006 MAY, H. U., A. HANSJÜRGENS Elektrische
Differentialtherapie1 Electric Differential
Therapy1 3 Posters (56 cm x 43 cm - in four
languages), prepared for the Medical center of
the Olympic Village during the Olympic Games in
Seoul 1988 1) Electric Differential Therapy (in
general), 2) Pain Management with EDiT 3)
Treatment of edema usin EDiT Karlsruhe,
Nemectron 1988
67
MAY, H. U., F. NIPPEL G. KONIECZNY
Schmerzbehandlung als Voraussetzung für die
Rehabilitation und die therapeutischen
Möglichkeiten der Interferenzstromtherapie.
Erfolgsraten und Anwendungsquoten bei
verschiedenen mit Schmerzen verbundenen
Krankheitsbildern - eine statistische Analyse.
Zeitschrift für Physikalische Medizin 11, 63 -
67, 1982 MAY, H. U., F. J. NIPPEL, A.
HANSJÜRGENS K. MEYER-WAARDEN Acceleration of
ossification by means of interferential
current. In DIXON, A. D., B. G. SARNAT
(editors) Normal and abnormal bone growth
Basic and clinical research, pages 469 478
(1985). Progress in Clinical and Biological
Research, Vol. 187, New York Alan R. Liss, Inc.
1985 MEYER, J. Les courants croisés de moyenne
fréquence à composante interférencielle de basse
fréquence (courant de Nemec) en dermatologie.
Synthèse de Sémiologie et Thérapeutique 23, 3
(1952)
68
MONJÈ, M. Über die Wirkung von Wechselströmen
verschiedener Frequenz auf die Hautsensibilität. Z
eitschrift für Sinnesphysiologie 67, 2 18
(1936) NEMEC, H. Reizstromtherapie mit
Interferenzströmen. Der Deutsche Badebetrieb 51,
320 323 (1960) NIKOLOVA-TROEVA, L.
Physiotherapie der chirurgischen Erkrankungen.
München, Berlin, Wien Urban Schwarzenberg
1970 NIKOLOVA-TROEVA, L. Lecenije s
interferenten tok. (Behandlung mit
Interferenzstrom) Sofia Medizina i Fiskultura
1971 NIKOLOVA-TROEVA, L. Treatment with
interferential current. Edingurgh, London,
Melbourne, New York Churchill Livingstone
1987 NIKOLOVA, L., M. DAVIDOV
Fermentaktivitäten in traumatisierten Nerven und
ihre Beeinflussung durch Interferenzströme
(Experimentelle Untersuchungen). Voprosy
Kurortol., Fisiotherap. i lecebn. Fisic. Kultury
43, 54 57 (1978)
69
NORDENSTRÖM, B. W. E.  Biologically closed
electrical circuits Clinical experimental and
theoretical evidence for an additional
circulatory system. Stockholm, Sweden Nordic
Medical Publications 1983 NOSZVAI-NAGY, M.
Wirkung mittelfrequenter Ströme auf Zellen in
Suspension. Diplomarbeit, Universität Karlsruhe,
Fakultät für Bio- und Geowissenschaften, März
1988 NOSZVAI-NAGY, M. Wirkung des
Mittelfrequenzstromes auf nicht-erregbare Zellen.
Dissertation. Universität und Kernforschungszentr
um Karlsruhe, 1993/94 PATTERSON, M. Hooked?
NET The new approach to drug cure. London Faber
Faber 1986
70
PEKAR, R. Die perkutane Galvano-Therapie bei
Tumoren. Schwachstrombehandlung von zugänglichen
Neoplasmen und ihre vitale Hybridisation in
Theorie und Praxis Wien, München, Bern Wilhelm
Maudrich 1988 PEKAR, R. Die perkutane
Bio-Elektrotherapie bei Tumoren. Eine
Dokumentation zu Grundlage und Praxis der
perkutanen Galvanotherapie Wien, München, Bern
Wilhelm Maudrich 1996 PETROW, W. Untersuchungen
über die Wirkung mittelfrequenter
Interferenzströme auf humane Tumorzellen Inaugural
dissertation. Institut für Anatomie und
Zellbiologie der Universität Marburg 1988
71
PETROW, W., H. W. KREYSEL Adjuvant therapy of
malignant melanoma by interferen tial
currents 21. Deutscher Krebskongreß, Hamburg,
7.-11. März 1994 21th National Cancer Congress of
the German Cancer Society Supplement to Journal
of Cancer Research and Clinical Oncology Vol.
120, 05.09.04 (1994) RACHMILEVIC, L. S., I.
A. JURASOVA Primenenije peremennovo toka castotoi
6 kHz dlja elektrostimulazii myschz w
eksperimentje i klinikje. Voprosy Kurortol.,
Fisiotherap. i lecebn. Fisic. Kultury 34, 515
520 (1969) REICHSTEIN, L., S. LABRENZ, D.
ZIEGLER S. MARTIN Effective treatment of
symptomatic diabetic polyneuropathy by
high-tone-frequency external muscle
stimulation. Diabetologia 48, 824 828
(2005) RIFE, R. R. History of the development
of a successful treatment for cancer and other
virus, bacteria and fungi. Rife Virus Microscope
Institute, San Diego, Ca., 1953
72
SAVERY, F., A. A. ORTIZ H. U. MAY Clinical
application and effects of EDiT and Endosan
treatment on diabetic neuropathy and gangrene of
toe Advances in Therapy 7, 283 288
(1990) SAVERY, F., A. A. ORTIZ, O. HAIKAL, K.
FATHIE, G. S. CHOUDHURY, H. U. MAY R.
SORGNARD Electric differential treatment (EDiT)
and Endosan treatment for ischemic
diseases. Advances in Therapy 8, 11 21
(1991) SAVERY, F., F. SILVER, R. EDWARD, A.
FANN, R. MANN, C. ROGERS, H. U. MAY R.
SORGNARD Assessment of electric differential
treatment (EDiT) and Endosan treatment for
ovarian cysts and concomitant symptoms Advances
in Therapy 8, 243 249 (1991) SCHWARZ,
F. (Physiolog. Inst. Universität
Leipzig) Über die Reizung sensibler Nerven des
Menschen durch mittelfrequente Wechselströme.
Pflügers Arch. 247, 405 440 (1944)
73
THIES, H. A., W. DIETRICH Eine neue
therapeutische Möglichkeit bei inoperablen
Adenocarcinomen (des Magen-Darm-Traktes)A new
therapeutic possibility in cases of inoperable
adenocarcinoma of the bowel tractLecture No.
6. VIII. Heilbronner Kolloquium über klinische
Chirurgie I. Städt. Chirurg. Klinik Heilbronn, 3.
Oktober 1981 Heilbronn VERAGUTH, O., R.
SEYDERHELM Über raschwirkende Beeinflussung
abnormer Leukozytenbilder durch ein neues
Verfahren. I. und II. Mitteilung. Münch. Med.
Wochenschr., 2211 2214 (1913) und 301 304
(1914) WILK, M., W. W. FIBIGER B.
FRANZUK Zastowanie terapii energotonowej w
rehabilitacji pacjentów po uszkodzeniach tkanek
miekkich stawu kolanowego. The application of
high-tone power therapy in rehabilitation of
patients with soft-tissue damage to the knee
joint. Fizjoterapia Polska (Polish Journal of
Physiotherapy) 2, 118 121 (2002)
74
(No Transcript)
75
(No Transcript)