Biotechnology and Medicine - PowerPoint PPT Presentation

Loading...

PPT – Biotechnology and Medicine PowerPoint presentation | free to download - id: 467cf2-MmU0M



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

Biotechnology and Medicine

Description:

Biotechnology and Medicine Prof. S.K.Panda Department of Pathology All India Institute of Medical Sciences Micro Fludic Peltier Microarray Electromotive Nucleic acid ... – PowerPoint PPT presentation

Number of Views:526
Avg rating:3.0/5.0
Slides: 21
Provided by: Dr1730
Learn more at: http://nis.apctt.org
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Biotechnology and Medicine


1
Biotechnology and Medicine
Prof. S.K.Panda Department of Pathology All India
Institute of Medical Sciences
2
Translational Medicine has Varying Meanings
The most explicit understanding is
possibly Research where in a basic laboratory
discovery becomes applicable to the diagnosis,
treatment or prevention of a specific disease
Bedside
Bench
3
The Kind of Man Power Required
  1. Physician Scientists. (with or without formal
    MD-PhD).
  2. Collaborative groups consisting of Investigators
    interested in basic understanding in physical,
    Chemical and Biological sciences with Physicians
    interested in solving specific problems.

4
Areas
  • There are unlimited possibilities. However, the
    common areas
  • Molecular-Cell Biology ? Clinical Practice
  • Computational Intelligence ? Interface with
    Physiology
  • Physical Chemical Research ? Application in
    Biology

5
  • Basic research leads to clinical application
  • Inter disciplinary research collaboration
  • Educational programmes (MD/Ph.D. physician
    scientist, DM-infectious disease including
    training etc.)

6
Virus Infection
Virus Infection
Cells
Replicon Transfection
Replicon Transfection
Un-infected Cells
Infected Cells
Micro Array
Micro Array
2D Maldi TOFF
2D Maldi TOFF
Mass Mass
Mass Mass
Other Studies
Other Studies
Comparison
Identification of molecules of interest
Used in
Diagnosis
Therapeutic Dev.
Clinical
Epidemiological
7
Electronic Cantilever
Diagnostic Platform
  • Antigen Ab Interaction
  • Mol. Hybridization

8
Physics
Electronics
Physiology
Engineering
Etc.
9
ST Lab-on-Chip allows Functions Integrations
ST Lab-on-Chip
Minatec Sept. 2003
10
Silicon Prototype 3Dim View
Minatec Sept. 2003
11
Lab-ON-a Chip
  • Micro Fludic
  • Peltier
  • Microarray
  • Electromotive Nucleic acid movement and
    Hybridization
  • Solid state portable laser scanner built to cell
    phone
  • Central data server.
  • Rural diagnostic

12
(No Transcript)
13
Biotechnology and therapeutics
Most diseases can be divided etiologically in to
the following categories
  • Hereditary diseases
  • Infectious diseases
  • Neoplastic diseases
  • Degenerative diseases
  • Inflammatory Diseases
  • Endocrine Diseases

14
Biotechnology can be used to treat several of them
  • By replacing altered genes.
  • By knocking out up-regulated genes.
  • By delivering deficient enzymes or other
    biological products.
  • By altering extraneously,response modifiers.
  • By making replacement cells invivo/ ex-vivo
  • By making transgenic organs for transplantation.
  • By producing antimicrobials, Ribozymes and gene
    silencing RNA.

15
RNA interference
  • RNA interference (RNAi) is a cellular mechanism
    to regulate the expression of genes and the
    replication of viruses.
  • Mediated by double-stranded small interfering RNA
    molecules (siRNA).
  • RNAi technology is a comparatively recent
    discovery believed by scientists to constitute an
    important aspect of a cells natural defence
    mechanism against parasitic viruses.
  • Critically, the cell responds to a foreign
    (double stranded) form of siRNA introduced into
    the cell by destroying all internal mRNA with the
    same sequence as the siRNA.

16
(No Transcript)
17
Cell Therapy
  • Cell-based therapies to treat disease, which is
    often referred to as regenerative or reparative
    medicine.
  • Two kinds of stem cells from animals and humans
  • Embryonic stem cells (In the developing fetus,
    stem cells in developing tissues give rise to the
    multiple specialized cell types that make up the
    heart, lung, skin, and other tissues).
  • Examples- Parkinson's disease, diabetes, and
    heart disease.
  • Adult stem cells (bone marrow, muscle, and brain,
    discrete populations of adult stem cells generate
    replacements for cells that are lost through
    normal wear and tear, injury, or disease)

18
Regenerative Medicine Potential Using Adult Stem
Cells
19
Synthetic Biology
  • Engineering of new biological components and
    organisms and redesign of existing ones.

20
(No Transcript)
About PowerShow.com