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Making Genetics Easy and Fun!

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Making Genetics Easy and Fun! Kristin Majda CSU Channel Islands kristin.majda415_at_csuci.edu Kristin Majda Education BS Biology & Minor in Professional Writing, U.C ... – PowerPoint PPT presentation

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Title: Making Genetics Easy and Fun!


1
Making Genetics Easy and Fun!
  • Kristin Majda
  • CSU Channel Islands
  • kristin.majda415_at_csuci.edu

2
Kristin Majda
Making Genetics Easy and Fun!
  • Education
  • BS Biology Minor in Professional Writing, U.C.
    Santa Barbara
  • Single Subject Clear Credential with CLAD, Cal
    State Northridge
  • MS Biotechnology MBA, Cal State Channel Islands
  • Experience
  • Technical Writer
  • Ventura County High School Science Teacher
  • Oxnard College Instructor Biology, Microbiology
  • CIRM Grant Analyst at Cal State Channel Islands
  • VP of Gold Coast Science Network (GCSN),
    Operating Council for the Discovery Center for
    Science and Technology, Bio Science Alliance
    (BSA) Workforce Development Group, American
    Association for the Advancement of Science (AAAS)

3
Agenda
Making Genetics Easy and Fun!
  • This presentation intends to
  • Demonstrate a fun lesson teachers can use to
    reinforce concepts of meiosis and Mendelian
    Genetics
  • Introduce teachers to excellent resources for
    understanding and teaching genetics and
    biotechnology

4
Fun Activities
Making Genetics Easy and Fun!
  • Lung Model (not genetics, but super cool!)
  • Mitosis and Meiosis Play Dough Activity
  • Mitosis and Meiosis Puzzle Activity
  • Protein Synthesis Modeling Activity (using the
    Preproinsulin sequence)
  • Can integrate peer-reviewed journal articles into
    the curriculum using this lesson based on the
    1980 paper that solved the structure of insulin
    Nucelotide Sequence of Human Preproinsulin
    Complementary DNA published in Science.

5
Fun Activities
Making Genetics Easy and Fun!
  • Lung Model (not genetics, but super cool!)
  • Mitosis and Meiosis Play Dough Activity
  • Mitosis and Meiosis Puzzle Activity
  • Protein Synthesis Modeling Activity (using the
    Preproinsulin sequence)
  • Can integrate peer-reviewed journal articles into
    the curriculum using this lesson based on the
    1980 paper that solved the structure of insulin
    Nucelotide Sequence of Human Preproinsulin
    Complementary DNA published in Science.

6
Mitosis Class Activity
Interphase DNA Synthesis
Use play dough to act out the steps of mitosis
  • 1. Prophase
  • Chromatin condenses to form chromosomes
  • Mitotic spindle begins to form
  • 2. Metaphase
  • Mitotic spindle attaches to chromatid pairs and
    pulls them into alignment at center of cell
  • 3. Anaphase
  • Centromeres replicate
  • Mitotic spindle pulls chromatids apart to
    opposite sides of cell
  • 4. Telophase
  • The cell membrane invaginates and pinches off
    between the two daughter cells

7
Meiosis Class Activity
Use play dough to act out the steps of meiosis
Anaphase I 5. Random Assortment
7. Prophase II 8. Metaphase II 9. Anaphase
II 10. Telophase II
Telophase I 6. Cytokinesis
Interphase 1. DNA Synthesis
8
Fun Activities
Making Genetics Easy and Fun!
  • Lung Model (not genetics, but super cool!)
  • Mitosis and Meiosis Play Dough Activity
  • Mitosis and Meiosis Puzzle Activity
  • Protein Synthesis Modeling Activity (using the
    Preproinsulin sequence)
  • Can integrate peer-reviewed journal articles into
    the curriculum using this lesson based on the
    1980 paper that solved the structure of insulin
    Nucelotide Sequence of Human Preproinsulin
    Complementary DNA published in Science.

9
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

10
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

Reinforce and help students differentiate between
phenotype and genotype Reinforce that genetic
traits are determined by genes, which are found
on chromosomes Demonstrate the difference
between autosomes and sex chromosomes
Demonstrate that many organisms, like humans,
have two sets of each gene unless it occurs on
the Y chromosome
11
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Decorate a pet paper bag with traits that
    adhere to this given set of phenotype choices

Gender male or female? Tail tail or no tail?
(females cannot have tails) Eye Shape round or
oval (almond) shaped? Eye Color brown, blue,
green, yellow? Eyelashes has eyelashes or is
lashless? Nose Shape circular or triangular? Hair
Color black, brown, or yellow? Ear Shape round or
pointed?
12
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Fill in Table of Alleles for your paper bag pet
    that reflect its genotype for each trait

13
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Create chromosomes for your paper bag pet that
    reflect its genotype for each trait

For Females
14
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Create chromosomes for your paper bag pet that
    reflect its genotype for each trait

For Males
15
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

Reinforce and help students differentiate between
phenotype and genotype Reinforce that genetic
traits are determined by genes, which are found
on chromosomes Demonstrate the difference
between autosomes and sex chromosomes
Demonstrate that many organisms, like humans,
have two sets of each gene unless it occurs on
the Y chromosome
16
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

Demonstrate the steps of meiosis and how this
process promotes genetic variation through
mutations (that occur during DNA replication),
crossing over, and random segregation/assortment D
emonstrate the law of independent
assortment Demonstrate how meiosis results in
four genetically unique gametes Demonstrate how
sexual reproduction promotes genetic diversity
through fertilization (joining gametes from two
different individuals)
17
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Create gametes for your pet paper bag
  • Step 1 DNA replication

For Males
For Females
18
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Create gametes for your pet paper bag

Step 2 Crossing Over
Random assortment
Crossing Over
Step 3 Random Assortment
Step 4 First cell division
19
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Create gametes for your pet paper bag

Step 5 Second cell division
20
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Find a mate and procreate
  • This is their FAVORITE part
  • Students LOVE to have SEX

21
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

Demonstrate the steps of meiosis and how this
process promotes genetic variation through
mutations (that occur during DNA replication),
crossing over, and random segregation/assortment D
emonstrate the law of independent
assortment Demonstrate how meiosis results in
four genetically unique gametes Demonstrate how
sexual reproduction promotes genetic diversity
through fertilization (joining gametes from two
different individuals)
22
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
Introduce or reinforce Mendelian genetics and
practice making and using Punnett
squares Demonstrate sex-linked inheritance and
differentiate between inheritance patterns of
traits on the X chromosome versus the y
chromosome Differentiate between linked genes and
genes that independently assort Reinforce
dominant versus recessive allele expression You
can also modify the project to make one or more
sets of alleles demonstrate codominance or
incomplete dominance
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

23
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Fill out the Punnett Square Worksheet
  • There are two versions, one provides more help
    for less advanced students.

24
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Fill out the Punnett Square Worksheet
  • There are two versions, one provides more help
    for less advanced students.

25
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Fill out the Punnett Square Worksheet
  • There are two versions, one provides more help
    for less advanced students.

26
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
Introduce or reinforce Mendelian genetics and
practice making and using Punnett
squares Demonstrate sex-linked inheritance and
differentiate between inheritance patterns of
traits on the X chromosome versus the y
chromosome Differentiate between linked genes and
genes that independently assort Reinforce
dominant versus recessive allele expression You
can also modify the project to make one or more
sets of alleles demonstrate codominance or
incomplete dominance
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

27
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  1. Decorate a pet paper bag with traits that
    adhere to a given set of phenotype choices
  2. Fill in Table of Alleles and create chromosomes
    for your paper bag pet that reflect its genotype
    for each trait
  3. Create gametes for your pet paper bag
  4. Find a mate and procreate
  5. Fill out the Punnett square worksheet to predict
    the traits of your offspring
  6. Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill out
    the birth certificate

Final check for understanding can students go
from genotype ? phenotype
28
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
29
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
  • Method 1 Use as a culminating project at the end
    of your genetics unit to reinforce key concepts
  • or
  • Method 2 Use as a thematic project that spans
    your genetics unit and teach key concepts as you
    go

30
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
Method 1 Culminating Project
  • Day 1 Decorate a pet paper bag with traits
    that adhere to a given set of phenotype choices
  • Day 2 Create chromosomes for your paper bag pet
    that reflect its genotype for each trait (use
    rest of period to introduce or reinforce
    meiosis)
  • Day 3 Create gametes for your pet paper bag
  • Day 3 Find a mate and procreate
  • Day 4 Fill out the Punnett square worksheet to
    predict the traits of your offspring (first
    introduce or reinforce Mendelian genetics)
  • Day 5 Give birth decorate your baby bag with
    phenotypes that match its genotypes and fill
    out the birth certificate

31
Paper Bag Pets A Genetics Project
Making Genetics Easy and Fun!
Method 2 Thematic Unit Centered Around Project
  1. Teach genes, traits, and phenotypes
  2. Decorate pet paper bag with phenotypic traits
  3. Teach chromosomal structure and packing
  4. Create chromosomes for your paper bag pet that
    reflect its genotype
  5. Teach DNA replication, mitosis, and meiosis
  6. Create gametes for your pet paper bag
  7. Teach sexual versus asexual reproduction
  8. Find a mate and procreate
  9. Reinforce mitosis and consider optional
    enrichment topics related to developmental
    biology, embryology, stem cell technology, etc
  10. Teach Mendelian genetics
  11. Fill out the Punnett square worksheet to predict
    traits of offspring
  12. Give birth decorate baby bag with phenotypes
    that match its genotypes and fill out the birth
    certificate
  13. Follow up with protein synthesis (gene ? protein
    ? trait)

32
Agenda
Making Genetics Easy and Fun!
  • This presentation intends to
  • Demonstrate a fun lesson teachers can use to
    reinforce concepts of meiosis and Mendelian
    Genetics
  • Introduce teachers to excellent resources for
    understanding and teaching genetics and
    biotechnology

33
Resources for Teaching Genetics
Making Genetics Easy and Fun!
  • Genetics and molecular biology involve abstract
    concepts
  • Animations are critical they engage students
    and enable them to visualize microscopic and/or
    abstract principles
  • The DNA Learning Center (DNALC) includes
  • Animations
  • Interactive websites
  • Curriculum development tools
  • Thematic lessons/units
  • Reference material
  • www.dnalc.org/resources/animations

34
Resources for Teaching Genetics
Making Genetics Easy and Fun!
www.dnalc.org
Real-time animations of transcription,
translation, DNA replication, and many
biotechnologies - Many are downloadable
35
Resources for Teaching Genetics
Making Genetics Easy and Fun!
http//www.dnalc.org/resources/3d/index.html
36
Resources for Teaching Genetics
Making Genetics Easy and Fun!
http//www.dnalc.org/resources/3d/index.html
37
Resources for Teaching Genetics
Making Genetics Easy and Fun!
http//www.dnalc.org/resources/3d/index.html
38
Resources for Teaching Genetics
Making Genetics Easy and Fun!
http//www.dnalc.org/resources/3d/index.html
39
Resources for Teaching Genetics
Making Genetics Easy and Fun!
  • Genetic Basics (NIH Publication No. 01-662) Free
    Guide from National Institutes of Health.
    http//www.nigms.nih.gov/
  • The Genes We Share with Yeast, Flies, Worms, and
    Mice Free guide from the Howard Hughes Medical
    Institute, Office of Communications, 4000 Jones
    Bridge Road, Chevy Chase, Maryland, 20815-6789.
    http//www.hhmi.org
  • The Human Genome Project
  • http//www.ornl.gov/sci/techresources/Human_Genome
    /home.shtml
  • http//www.pbs.org/wgbh/nova/genome/program.html
  • http//www.pbs.org/wgbh/nova/genome/sequ_flash.htm
    l
  • Award Winning Genetics Resources from the
    University of Utah
  • http//learn.genetics.utah.edu
  • http//teach.genetics.utah.edu

40
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • Biotechnology
  • enables us to show real-world applications of
    genetics and provides opportunities for
    meaningful labs
  • is part of the CA science standards for high
    school biology, but has applications to many
    standards across the sciences for all grade
    levels
  • combines disciplines like genetics, molecular
    biology, biochemistry, embryology and cell
    biology with applications in medicine,
    agriculture, environmental science, materials
    science, bio-fuels, etc.

41
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • Jobs in the biotechnology sector are increasing
    and there is a critical need for a vast range of
    skilled workers, from lab assistants to PhD
    researchers
  • Biology and chemistry teachers can use
    applications of biotechnology to strongly engage
    student interest and stimulate student-directed
    investigation and experimentation in their
    classrooms

42
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • Biotechnologies include methods to
  • Cut (restriction enzymes), paste (ligation), and
    move DNA segments from one chromosome to another
    (recombinant DNA) and/or one cell to another
    (transformation) (Genetic Engineering)
  • Make many copies of DNA segments (amplification)
  • Identify individuals and/or diseases based on
    their unique DNA profiles (DNA sequencing, DNA
    fingerprinting, immunoassays, bioinformatics)
  • Determine evolutionary relationships
    (phylogenetics) within and between species
  • Turn genes up (upregulation) and down (down
    regulation), or on (gene activation) and off
    (gene silencing)
  • Grow cells (cell culture), manipulate stem cells
    to develop into specific tissue types
    (differentiation), or manipulate differentiated
    cells to regress back to stem cells
  • Create genetically identical copies of organisms
    (cloning)

43
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • Bruce Wallace Biotechnology Lab Program Amgen
    Foundation provides all materials and equipment
    (including reagents) for eight comprehensive
    biotechnology labs. http//www.bwbiotechprogram.co
    m

44
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • Fold it Protein folding game http//fold.it/porta
    l/info/science

45
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • 3D Molecular Designs Cool models of 3D molecular
    structures that provide nice hands-on experience.
    www.3dmoleculardesigns.com

Lends out molecular models for 2 weeks
http//cbm.msoe.edu/teachRes/library/index.html
46
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • DNA Sequencing Tutorial/Animation
    http//www.biostudio.com/case_freeman_dna_sequenc
    ing.html
  • Exploratorium Teacher Institute Four week
    program in summer that teaches how to make all
    kinds of do it yourself activities (email
    annar_at_exploratorium.edu or call 415-561-0313)
  • McGraw Hills Biotechnology Animations
  • http//highered.mcgraw-hill.com/sites/0072437316/s
    tudent_view0/chapter16/animations.html
  • Stem Cells
  • http//www.sumanasinc.com/scienceinfocus/sif_stemc
    ells.html
  • http//www.dnalc.org/resources/animations/stemcell
    s.html

47
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • ELISA Tutorials/Animations
  • http//www.sumanasinc.com/webcontent/animations/co
    ntent/ELISA.html
  • http//www.biology.arizona.edu/immunology/activiti
    es/elisa/technique.html
  • http//highered.mcgraw-hill.com/sites/0072556781/s
    tudent_view0/chapter33/animation_quiz_1.html
  • Pregnancy Test Animation Use this website and a
    pregnancy test from the Dollar Store to show your
    kids how antibodies are used to identify proteins
    in body fluids like blood and urine http//www.whf
    reeman.com/kuby/content/anm/kb07an01.htm
  • Microarray Tutorial/Animations http//www.bio.dav
    idson.edu/Courses/genomics/chip/chip.html
  • PCR Tutorial/Animation
  • http//www.maxanim.com/genetics/PCR/PCR.htm
  • http//www.youtube.com/watch?vZmqqRPISg0g
  • http//www.dnalc.org/resources/animations/pcr.html

48
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • Recombinant DNA Tutorial/Animation
  • http//www.bioteach.ubc.ca/TeachingResources/Appli
    cations/GMOpkgJKloseGLampard2.swf
  • http//www.bioteach.ubc.ca/TeachingResources/Appli
    cations/GMOpkgJKloseGLampard2.swf
  • http//webapps.css.udel.edu/biotech/rDNA.html
  • Gel Electrophoresis Tutorial/Animation
  • http//www.dnalc.org/ddnalc/resources/electrophore
    sis.html
  • http//www.dnalc.org/resources/animations/gelelect
    rophoresis.html
  • http//learn.genetics.utah.edu/content/labs/gel/

49
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • PyMOL to visualize small molecules and
    macromolecules in 3D. http//www.pymol.org/
  • Protein Data Bank is a database that includes
    structural and functional information about
    proteins, including the FASTA files needed to
    display them in PyMOL. http//www.rcsb.org/pdb
  • Jmol is a simple tool for molecular visualization
    that has an online gallery for easy access, with
    limited control over the appearance of molecules.
    http//molvis.sdsc.edu/fgij/index.htm
  • Biomolecular Explorer 3D provides information
    about and 3D images of relevent biological
    macromolecules right on the website.
    http//www.umass.edu/molvis/bme3d/index.html
  • PredictProtein provides analyses protein you
    input and predicts structure. http//www.predictpr
    otein.org/
  • Proteomics Tools http//www.expasy.ch/tools/

50
Resources for Teaching Biotechnology
Making Genetics Easy and Fun!
  • PubMed includes links to full text journal
    articles and other related resources.
    www.ncbi.nlm.nih.gov/entrez/
  • SWISS-PROT protein database. http//www.expasy.org
    /sprot/
  • SDSC Biology Workbench allows scientists to
    search many protein and nucleic acid sequence
    databases. http//workbench.sdsc.edu
  • JCVI-CMR (Comprehensive Microbial Resource)
    maintains databases that include prokaryotic,
    plant, fungal, and parasitic genomes.
    http//cmr.jcvi.org/tigr-scripts/CMR/CmrHomePage.c
    gi
  • ORF Finder scans a FASTA sequence for a segment
    of DNA to determine potential open reading frames
    (sections that code for a gene)
    http//www.ncbi.nlm.nih.gov/gorf/gorf.html
  • Lipid bank http//lipidbank.jp/
  • Glycan Structure Database www.glycosuite.com

51
Thank You!
Making Genetics Easy and Fun!
  • Questions?
  • Kristin Majda kmajda_at_yahoo.com
  • kristin.majda415_at_csuci.edu
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