Biophysics: An Introduction

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Biophysics An Introduction

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Syllabus

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  Cotterill,???Wiley)
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Syllabus

• Introduction
• Elements of Quantum Physics and Thermodynamics
• Chemical Binding
• Energies, Forces and Bonds
• Chemical Reaction
• Transport Processes
• Biopolymers DNA, RNA
• Biopolymers Proteins
• Special Topics / Discussion

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First Question

• What is Life?

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Introduction to Biophysics

• Definition
• Physical Principles in Life
• Scales of the Biological World
• Research Techniques
• Current Issues in Biophysics

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Definition

• Biophysics (also biological physics) is an
  interdisciplinary science that applies theories
  and methods of the physical sciences to questions
  of biology. (from Wikipedia)
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Entropy Lowered
High Entropy State
Low Entropy State
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Where does the negative entropy come from?

• The sun is the source of negative entropy
• The density of the entropy flux at the Earths
  surface -1 W/m2K
• The second law of thermodynamics is not violated
  because the Earth is not a closed system

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Size Scales of Biology

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• ??? 10 mm 30m
• ???Earth

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SARS VIRUS
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Potato Starch
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Diameter of hair 100 micron
Micromachine
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MAZINGER Z 18 M
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Statue of Liberty 91 M
Blue Whale 30 M
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Time Scales in Biology

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Jan 1 000000Big Bang
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June Formation of Galaxy
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September Emergence of Solar System and Earth
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Oct. 1 First Living Creature Gloeocapsa (???)
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Nov. 1 Eukaryote(????)??
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Dec. 1 ???????,????
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Dec. 15 ???????
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Dec. 20 ?????(invertebrate)??
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Dec. 21 First oceanic plankton prospering of
trilobites(???)
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Dec. 22 Ordovician period(??????), first
vertebrates (fish)
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Dec. 23 Silurian period(?????),
sporophytes(????)conquer land
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Dec. 24 Devonian period(???), first insect
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Dec. 25 Carboniferous period(???), first
conifers (????), first reptile(???)
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Dec. 26 Permian period(???), first dinosaur
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Dec. 27 Triassic period(???), first mammals
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Dec. 28 Jurassic period(???), dinosaurs diversity
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Dec. 29 Cretaceous period(???), first bird
(Archaeopteryx)
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Dec. 30 Tertiary period(???), first primates
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Dec. 31, 223000 First Human Being
(australopithecus)
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Dec. 31, 230000 Stone Tools
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Dec. 31, 235900 Agriculture
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Dec. 31, 235954 Writing
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Dec. 31, 235956 Bronze Age
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New Year 000000 Time Recording
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New Year 000003 Modern Time
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Research Techniques

• X-Ray Diffraction
• Nuclear Magnetic Resonance
• Scanning Tunnelling Microscopy
• Atomic Force Microscopy
• Optical Tweezers
• Patch Clamping
• Molecular Dynamics
• Monte Carlo Simulation

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Current Focused Issues in Biophysics

• Protein Folding
• Tissue Differentiation
• Microscopic Recognition
• Consciousness
• and many many others

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Protein Folding

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Blue Gene The Fastest Computer in the World
(32786 CPUs, 70.7 TFLOPS)
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Tissue Differentiation

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• ......

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Microscopic Recognition

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Consciousness

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