The mitochondrial free radical theory of aging posiits that physiological decline is due to

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The mitochondrial free radical theory of aging
posiits that physiological decline is due to
Accumulated effects of free radical damage
stemming from mitochondrial respiration. We Are
testing this hypothesis using Drosophila carrying
different mtDNA haplotyes. Our data so far Show
a correlation between the degree of divergence
between mtDNNAs and the amount of effect they
Have on altering longevity. Kann, L. M., E. R.
Rosenblum, and D. M. Rand. 1998. Aging, mating,
and the evolution of heteroplasmy for mtDNA
length variants in Drosophila melanogaster. Proc.
Natl. Acad. Sci. 952372-2377 Fry, A. and Rand
D.M. 2002. Wolbachia interactions that determine
Drosophila melanogaster survival. Evolution
56(10) 1976-81 Rand, Fry, Sheldah, 2003.
Nuclear--mitochondrial interaction effects on
Drosophila longevity. In prep.