Nonfouling surfaces are surfaces that resist the adsorption of proteins andor adhesion of cells'

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Nonfouling surfaces

• Nonfouling surfaces are surfaces that resist the
  adsorption of proteins and/or adhesion of cells.
• Generally
• Surfaces that strongly adsorb proteins exhibit
  cell adherence
• Essential for
• - Implanted devices
• Catheters
• Blood compatible materials
• etc.

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Nonfouling surfaces

• Most examples based on polymeric materials
• Poly(ethylene glycol) most common
• Other materials
• Poly(2-hydroxyethyl methacrylate)
• Poly(acrylamide)
• Phospholipid bilayers
• Polysaccharides
• Etc.

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Nonfouling surfaces

• Nonfouling properties are related to
  thermodynamics
• DGad DHad T DSad
• Factors favoring adsorption
• Van der Waals interactions (DH)
• Ion-ion interactions (DH)
• Desorption of water molecules (DS)
• Unfolding of protein (DS)

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Nonfouling surfaces

• DGad DHad T DSad
• Factors opposing adsorption
• Retention of bound water (DH)
• Unfolding of protein (DH)
• Chain compression (DH and DS)
• Protein hydrophobic exposure (DS)
• Osmotic repulsion (DS)

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Nonfouling surfaces

• Poly(ethylene glycol) ideal
• - Binds H2O
• Has no ionic groups
• Chain compression effects
• Osmotic repulsion

J Am Chem Soc. 2003 Apr 9125(14)4253-8
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Nonfouling surfaces
Covalent Immobilization of PLL-g-PEG onto
Aldehyde Plasma Polymer Coated Surfaces Diploma
Thesis, Thomas M. Blättler