Track A Basic Science Final Rapport

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Track A -- Basic ScienceFinal Rapport
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• Major themes in basic HIV/AIDS research that
  emerged at the XVII IAS Conference
• Determinants of HIV transmission
• Cell restriction and genetic factors
• Any good news on the vaccine front?
• Appreciation of the complexity of the interaction
  between HIV and the host immune system (i.e. is
  it time to re-visit the HIV immunology paradigm?)

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• Better understanding of the determinant of HIV
  transmission
• The extreme genetic bottleneck observed during
  HIV transmission may be less severe in the event
  of non-monogamous infections. Role of STIs and
  mucosal inflammation? (Eric Hunter)
• Role of animal models is this an area where
  humanized mice may be particularly useful?
  (Garcia-Martinez the BLT mice Kish-Catalone
  the humanized cervico-vaginal tissue model)
• Transmission of CXCR4-tropic viruses (Petropoulos)

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• Cell restriction genetic factors
• Host restriction factors from TRIM5a and
  APOBEC3G to Tetherin and what else? (Mario
  Stevenson)
• Complexity of the molecular interaction between
  HIV and host cells siRNA library to identify
  cellular genes that restrict HIV replication in
  Jurkat cells (Jeang)
• Use of double-fluorescent viruses, core-GFP
  S15-Cherry-membrane, to study virus uncoating
  (Perez/Tom Hope)

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• Any good news on the HIV vaccine front?
• Improvement of DNA as an AIDS vaccine platforms
  by the use of electroporation and the addition of
  adjuvants such as IL-12, IL-15, etc
  (Boyer/Weiner)
• The specificities of CD8 T cell responses during
  primary HIV-1 infection appears to determine the
  later level of virus setpoint (Streeck/Altfeld)
• Studies of elite controllers may be very
  informative-- role of virus fitness (Arts,
  Miura), cell restriction factors, and host immune
  system.

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• Appreciation of the complexity of the interaction
  between HIV and the host immune system
• Pathogenic role of chronic immune activation in
  favoring HIV disease progression
  (Lisco/Margolis).
• Studies of natural SIV infection in African Green
  monkeys (Gaufin/Apetrei) and Sooty Mangabeys.
• Role of co-pathogens is GBV-C a key to
  understand AIDS pathogenesis? (Stapleton)
• PD-1, TIM3, and the exhaustion of HIV-specific
  T cell responses-- where do we go from here?
  (Conrad, Addo)

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Track A -- Basic ScienceFinal Rapport

• A Special Thanks To
• Janelle Averill, Emily Blitz, Krista Newhouse
• All the volunteers at the Rapporteur Office