Stewardship in Biotechnology Research A few examples within the College of Agriculture Iowa State Un

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Stewardship in Biotechnology Research???????????
A few examples within the College of
Agriculture Iowa State University????????????

• Dr. Mark Westgate
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• Professor of Crop Production and Physiology
• Department of Agronomy
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Research on Transgenic Corn???????

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• Improving maize quality traits
• Dr. Paul Scott, USDA-ARS and Department of
  Agronomy
• Animal vaccines in corn
• Plant Sciences Institute Biopharmaceutical
  Initiative
• Dr. Kan Wang, Director Plant Transformation
  Facility
• Gene Confinement
• Modeling Pollen Dispersal, Dr. Mark Westgate,
  Department of Agronomy
• Economic Cost of Uncontrolled Pollen Flow
• Dr. Dermot Hayes, Pioneer Chair of Agribusiness
• BIGMAP
• Biosafety Institutefor Genetically Modified
  Agricultural Products, Dr. Manjit Misra, Director
  Seed Science Center

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Maize quality traits??????

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• Dr.Scotts lab is using a combination of
  biochemistry, molecular biology and traditional
  plant breeding to add value to corn

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Improving swine nutrition ? ? ? ? ? ?
alpha lactalbumin

• Sows milk contains alpha lactalbumin
• Alpha lactalbumin protein is an ideal corn feed
  additive
• Dr. Scott eveloped transgenic corn to produce
  this protein in the seed
• Lines are being developed for feeding trials

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Animal vaccines in corn????????
E. coli

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• Dr. Wangs group developed transgenic corn plants
  that produce a fully functional vaccine antigen
  against an E.coli toxin.
• Part of the Plant Science Institute
  Bio-pharmaceutical Initiative
• Feeding antigen-containing corn to mice protected
  them against E. coli enterotoxin and cholera
  toxin

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Stewardship of Plant-Made Pharmaceuticals and
Industrials ??????????

• Scientific issues
• Proof of concept, Genetic stability
• Regulatory requirements Product comparability,
  purity
• Safety concerns Environmental impact, Product
  protection, Gene flow
• Commercialization Economic and Legal issues

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Confinement requirements in open field
trials?????????

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• Physical isolation 1 mile (1600m) from any other
  corn
• Temporal isolation planted 28 days from any
  other corn within 1600 m

APHIS Biotechnology Regulatory Services visits
each site to check
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2004 Colorado field site managed by Horan
Brothers, Agricultural Enterprizes2004
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• Physical isolation
• More than 4800 m from nearest corn field
• Temporal isolation
• Planted 28 days after nearest corn field

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APHIS Biotechnology Regulatory Services was
there to check
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Managing Transgene Flow????????

• Pollen production
• Flower development and function
• Physical dispersal in air
• Atmospheric conditions wind speed and
  direction, stability index, temperature, relative
  humidity
• Pollination biology
• Synchrony with female flower development and
  function

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Modeling pollen dispersal???????

• Dr. Westgate and colleagues have developed
  computer models to calculate the amount of pollen
  drift and the potential for gene flow from a
  field of transgenic corn

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Predicting potential for gene flow in corn
????????????

• Large field studies confirm model predictions of
  pollen dispersal
• Gene flow to non-transgenic corn was closely
  correlated with predicted pattern of pollen
  movement
• Loss of genetic purity can be predicted

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Economic Cost Associated with Pollen Flow From
Transgenic Crops?????????????????

• Dr. Hayes analyzes the cost and benefits of PMP
  corn.
• What would it cost to insure a hectare of corn
  against impurity due to pollen drift?
• Assuming 1 failure rate of male sterility, and
  impurity of 1 seed in 16 hectares, the cost
  should be about 28.50 per hectare

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• ????????????1,??16???1??????,????28.50??/??.

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BIGMAP Biosafety Institute for Genetically
Modified Agricultural Products Dr. Manjit
Misra, Director????????????? ??????????

• BIGMAP was created to provide science-based
  analysis of the risks and benefits of genetically
  modified plant and animal products.
• It provides guidance and education about GMAPs to
  help safeguard consumers and the environment.

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BIGMAP Biosafety Institute for Genetically
Modified Agricultural Products ?????????????

• Designed to ensure pharmaceutical crops are
  produced in a safe, responsible, well-managed and
  environmentally friendly manner.
• Methods developed help growers take advantage of
  new products to spur economic growth, while
  safeguarding valuable agricultural resources.

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BIGMAP Structure to Assess Risks of PMP
Corn BIGMAP???????????
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BIGMAP -- National Leadership in Stewardship of
Biotechnology ResearchBIGMAP?????????????????

• Build public trust
• Ensure food safety and security
• Enhance export issues based on science rather
  than politics/emotion
• Counter agro-terrorism

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Acknowledgement to the contributors??

• Dr. Paul Scott
• Dr. Kan Wang
• Dr. Susana Goggi
• Dr. Ray Arritt
• Dr. Dermot Hayes
• Dr. Manjit Misra

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