Synthos 3000

1
Synthos 3000

• Enhanced Microwave Assisted
• Organic Synthesis

2
Big Deal
in
Organic Synthesis
3
Contents

• Synthos 3000 - General Features
• Rotor System - General Information
• Rotor 16 - Details Vessels
• Rotor 8 - Details Vessels
• Accessories

4
A Versatile and Modular Microwave Platform System

• High performance rotors vessels

• Built-in magnetic stirrer

• Dual remote temperature sensing

• Sophisticated accessories

5
Synthos 3000 - General Features

• 1400W unpulsed microwave
• output power

• Dual magnetron system

• 66L PTFE coated cavity

• Large rotor drive ring

• Built in cooling unit

• Proven safety door

• Easy access to connectors

6
Pulsed vs. Unpulsed Power

• Reduced risk of spontaneous reactions
• Minimized occurence of hot spots

7
Built-In Cooling Unit

• No overheating during reaction
• Reduction of material stress
• Cooling within 20 minutes
• Safe exhaust of vapors after reaction
• Supports control of exothermic reactions by
  drawing off heat
• Integral part of the solvent safety system

8
Proven Safety Door

• Stable stainless steel door with window
• Pushbutton operation
• Magnetically supported opening and closing
• Overpressure release and resealing action
• 4 interlock switches
• Tested for more than 200.000 cycles

9
Built-In Controller

• Features
• Big, bright display
• Corrosion resistant and spill proof design
• 8 function keys
• Optional external keyboard
• Standard serial RS232 and parallel printer port

• Benefits
• Easily readable from across the lab
• No extra space required
• Compatible with LIMS

10
Intuitive Software

• Ready to use library with
• tested methods
• User can edit and store
• own methods

• Easy documentation
• Automated calibration
• Multitasking facilities

• Serial port for data transfer to PC
• Excel Plug-in for online data acquisition
• Printer Port

11
Documentation
12
Rotor Code
Synthos 3000 Rotors
Rotor 16HF100
Vessel volume (in mL)
Number of vessels (8 or 16)
Vessel material F ... fluoroplastic Q ... Quartz
glass
Vessel pressure M ... Medium press. (20/70 bar) H
... High press. (40/70 bar) SX ... Extremely
high pressure (60 or 80/120 bar)
13
Synthos 3000 Rotors

• 16-position Rotors
• Magazine-type rotor
• Screw Cap vessels
• Fluoroplastic vessels
• Medium or high pressure
• IR temperature control
• Magnetic Stirrer
• Options
• Reference p/T-sensor in one vessel

14
Synthos 3000 Rotors

• 8-position Rotors
• Closed "cage style" rotor
• Plugged vessels
• Fluoroplastic or quartz glass
• "X"tremely high pressure
• Pressure sensor on all positions
• IR temperature control
• Magnetic Stirrer
• Options
• Immersing temperature probe in .one vessel

15
Synthesis Applications

• Rotor 8SXF100
• High Pressure Reactions
• Solid-Phase Synthesis
• Pre-pressurized Reactions

• Rotor 8SXQ80
• High Pressure Reactions
• Metal Catalysis
• Pre-pressurized Reactions
• Near Critical Water Chemistry

• Rotor 16MF100/16HF100
• Standard Synthesis
• Medium Pressure Reactions
• Solid-Phase Synthesis
• Library Generation
• High Throughput Applications

16
10-fold Overpressure Safety

1. Tested Synthos 3000 methods library
2. Controlled pressure release after reaction
3. Efficient Cooling ("negative energy")
4. Pressure increase control
5. Pressure limit (e.g. 60 bar for XF100-vessels)
6. 120 bar safety disk ? overpressure tolerance
7. 140 bar test pressure (for 1 minute)
8. Bomb jacket resp. vessel holder
9. Closed rotor with protection lid
10. Stable oven cavity with resealing safety door

Active feature Passive feature
17
Rotor 16 Design
Protection lid with bayonet lock Shielded
sensor module Sensor vessel Venting
valve Seal Sapphire thermowell Cooling air
guide Bowl shaped rotor body IR measurement
port Rotor base
18
Optimized Vessel Design (MF/HF100)
Exhaust Portfor directed gas release
Screw Cap
Safety Disk Holder
Venting Screw
Safety release grooves
Lip-type Seal
Liner (PTFE-TFM)
Vessel Jacketreinforced PEEK or ceramics
19
MF100 HF100 Vessels

• Easy hand tightening of lip-type seals
• Hermetic closure, no loss
• Safety disks made of resistant metal alloy
• High overpressure tolerance
• Controlled venting insidethe oven after
  digestion
• Upgrade from MF to HF by changing vessel jackets

20
Rotor 16 - Reaction Vessels
MF100 vessel
Liner material PTFE-TFM
Pressure Jacket reinforced PEEK
Volume 100mL
Controlled pressure 20 bar (290 psi)
Max. rated pressure 70 bar (1000 psi)
Test pressure 140 bar (2000 psi)
Max. temperature 200C
HF100 vessel
PTFE-TFM
Ceramics
100 mL
40 bar (580 psi)
70 bar (1000 psi)
140 bar (2000 psi)
240 C
21
Rotor 8 Design
22
Rotor 8 - Reaction Vessels
SXF100 vessel
PTFE-TFM
Ceramics
100 mL
60 bar (870 psi)
120 bar (1740 psi)
140 bar (2000 psi)
260 C
SXQ80 vessel
Liner material Quartz
Pressure Jacket ---------
Volume 80mL
Controlled pressure 80 bar (1160 psi)
Max. rated pressure 120 bar (1740 psi)
Test pressure 140 bar (2000 psi)
Max. temperature 300C
23
Synthos 3000 Vessel Overview
24
Pressure / Temperature Sensor

• Optional available for Rotor 16

25
Temperature Sensor Accessory

• Temperature range 0 - 300 CAccuracy 1
• Shielded electronics module with wireless data
  transmission by IR-LED
• Quartz glass thermowell, compatible with all
  solvents and most acids
• Optional available for Rotor 8

26
Seal Forming Device

• Features
• For both types of seals
• Fits to Rotor 8 and 16
• Made of easy to clean materials

• Benefits
• Safe storage of caps
• Comfortable and fast vessel closure
• Avoids handling errors

27
Temperature Calibration Tool

• Features
• Automatic calibration for invasive T-sensors
• Connected to CAL plug of Synthos 3000
• Documentation and calculation automatically by
  the software

• Benefits
• Calibration within 15 min without manual work or
  calculation
• Accurate temperature measurement within 1
  uncertainty

28
Gas Loading Accessory

• Features
• Individual pre-pressurizing up to 20 bar
• Creation of inert or reactive gas atmosphere
• Easy bayonet connection for use with already
  closed rotor

• Benefits
• Simplified application of gaseous reagents in
  microwave reactions
• Substitition of toilsome autoclave systems

29
Filtration Unit / Rack 16
Filtration Unit Screw-on tool for convenient
solid phase applications without change of
vessels Various filters with different pore
size Filtration of precipitated products
Rack 16 For all kinds of vessels liners
30
An invasion of armies can be resisted, but
not an idea whose time has come
Victor Hugo (1802-1885)
Time has come for
Synthos 3000