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Applications of Nanomaterials in Biology

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detection and drug delivery for disease. many applications; cancer is major target ... monitor physiological conditions. blood pressure, hormone concentrations, ... – PowerPoint PPT presentation

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Title: Applications of Nanomaterials in Biology


1
Applications of Nanomaterials in Biology
  • A. Cellular communication in biological systems
  • Nanomaterial applications
  • 1. Biomedical applications
  • 2. Molecular recognition
  • 3. Biological assays
  • 4. Materials

hormone-receptor complex
2
Lipid soluble messenger pathway
3
Types of Cellular Communication
4
Signaling Outcomes
5
Cell growth and differentiation
6
Biomedical Applications
  • detection and drug delivery for disease
  • many applications cancer is major target

7
Disease diagnostics
Cross-sectional magnetic resonance image of
human brain
8
Brain showing tumor
9
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10
Hypothetical nanosensors in the brain
11
Drug Delivery for Disease
Cancer treatment
12
Progression of cancer development
13
Metastasis
14
  • delivery of agent (drug)
  • specificity of agent for
  • cancer cells
  • efficacy of agent
  • side effects

15
Molecular recognition
  • quantification of molecular interactions
  • discovery aspect pharmaceutical industry

16
Drug Discovery
17
heat?
18
Scripps- PARC enthalpy array
  • drug discovery uses
  • the nanocalorimeter
  • detects temperature
  • differences when
  • chemicals interact with
  • cells
  • sensitivity is 1 millionth
  • of a degree Celsius

19
Detection of Biomolecules
  • basic research, forensics,
  • environmental health, toxicology,
  • food safety
  • IR fluorescence, radioactive platforms

20
Kodak In Vivo Bioimaging System
21
Biological Assays
  • nanoscale genomics
  • biosensors

22
Genomic research
Worldwide government and non-profit funding in
excess of 1 billion
23
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24
Biosensors
  • monitor physiological conditions
  • blood pressure, hormone concentrations,
  • neural activity, body temperature

glucose and lactate sensor
25
  • glass substrate with
  • functionalized surface
  • (e.g., Ta2O5, TiO2,
  • Nb2O5)
  • antibodies (yellow)
  • attached to surface
  • capture proteins (green)

26
Passive inducible transponder tag
27
Materials
  • biomolecular engineering
  • biomotors

28
Bone replacement material OSferionTM
(b-tricalcium phosphate) from Olympus
29
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30
ATPase Biomotor
Montemagno et al., Cornell University
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