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Border Health Research

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Title: Border Health Research


1
Border Health Research
  • Texas Higher Education Coordinating Board
  • Research Assessment Program
  • November 9, 2006
  • University of Texas at El Paso

2
Pablo Arenaz Vice Provost and Dean of the
Graduate School Director Border Biomedical
Research Center
Roberto A, Osegueda Vice President for Research
Harry Meeuwsen Interim Dean College of Health
Sciences
Michael Eastman Dean College of Sciences
Robert Anders Dean School of Nursing Director Hisp
anic Health Disparities Research Center
3
Introduction
  • The border health program is a recognized
    resource for the region and also represents a
    vital state and national resource.
  • Many of the health problems once identified only
    with border regions are now found throughout the
    U.S.
  • UTEPs program in Border Health Research is
    gaining national recognition as a result of the
    importance of Border Health in Texas and overall
    impact on national health problems related to
    Mexican immigration throughout the United States.
  • New initiatives from state and national levels to
    strengthen the capacity of universities to
    achieve their goals in both border health
    research and education must be forthcoming

4
Major Health-Related Extramural funding
5
Border Health Research Mission
  • Provide the investment needed for the support of
    interdisciplinary bioscience and health science
    research in the pursuit of applied and clinical
    solutions to health related problems of the
    U.S./Mexico border region.
  • The goals are to increase the knowledge and the
    research base
  • Specific objectives include
  • develop new and support existing
    interdisciplinary basic, applied, and clinical
    research programs that are related to border
    health and environmental problems
  • to recruit and invest in new and existing
    biology/health science faculty whose research
    agendas fit the border health program
  • and to seek external funding required to support
    research on border health issues.

6
History
  • Created in FY 2002
  • Original purpose
  • Provide support for public service related to
    health and environmental problems that
    disproportionately affect Hispanics and residents
    in general of the U.S./Mexico border region
  • Expanded purposes
  • continue to emphasize border health challenges,
    developing both faculty and graduate research
  • new emphasis on countering the threat of
    bio-terrorism (BT), in collaboration with UTMB
  • working with the El Paso City/County Health
    Department Regional Laboratory to coordinate
    responses to BT threats.

7
  • The Border Biomedical Research Center has been
    the centerpiece to leverage and build capacity
    for the conduct of biomedical research.
  • The College of Health Sciences and the School of
    Nursing have been used as the foundation to build
    capacity and increase productivity in areas of
    public health.
  • CHS has also provided a foundation for expanding
    public health and clinical research programs
    through the Hispanic Health Disparities Research
    Center and helps coordinate health-related
    research in a number of departments at UTEP
    (e.g., the institutions Interdisciplinary Health
    Forum).
  • Faculty members in the BBRC and CHS have been
    joined by colleagues in chemistry, engineering
    and liberal arts in the border health research
    effort.

8
Organization Prior to September 1, 2006
9
Organization After September 1, 2006
10
Hispanic Health Disparity Research Center
  • In partnership with the UT Houston School of
    Public Health
  • Mentoring and training through collaboration
    across academic institutions
  • Health researchers focused on Hispanic health
    disparities
  • Innovation in health disparities research.
  • Funded by NIH, DHHS and National Center for
    Minority Health and Health Disparity.

http//hhdrc.utep.edu/
11
Hispanic Health Disparities Research Center
(HHDRC)
  • Primary purpose is to facilitate research related
    to Border health disparities.
  • The HHDRC has administrative, research and
    dissemination cores
  • Include faculty from both UTEP and the University
    of Texas at Houston Health Science Center, School
    of Public Health.
  • Through the cores and support staff, the Center
    provides infrastructure support for researchers,
    pilot funding for promising research, mentoring,
    and assistance with disseminating research
    findings.
  • HHDRC has a national Advisory Board of experts
    related to Hispanic health disparities and
    research methodologies.
  • The Center holds an Annual Summer Institute that
    features faculty development activities presented
    by leading experts in Hispanic health disparities.

12
Border Biomedical Research Center
  • The mission of the BBRC is to facilitate and
    expand the pathobiology research at UTEP by
    strengthening the research infrastructure of the
    institution. The BBRC, through collaborative
    efforts with nearby institutions, has become the
    focal point of pathobiology research that
    addresses the biomedical and health issues of the
    bicultural population of the El Paso/Ciudad
    Juarez region of the Texas-Mexico border.
  • The BBRC has a formal advisory committee that
    includes local, national, and international
    experts on health issues affecting the Texas
    Mexico border region. The entire committee meets
    once a year to review the accomplishments of the
    BBRC and its faculty and to provide direction for
    future efforts. Local board members participate
    in additional meetings through the year.

http//research.utep.edu/Default.aspx?aliasresear
ch.utep.edu/bbrc
13
BHR Funds
14
Border Health - FTE
15
FTEs
16
People supported by BHR
  • Lisa Bain, Associate Professor of Biology (FY
    2004, 2005)
  • Maria Duarte-Gardea, Assistant Professor of
    Health Promotion (FY 2004 and 2005)
  • Patrick Gurian, Assist. Prof. in Civil
    Engineering (Public Health) -- Departed in Aug.
    2004 (FY 2004)
  • Wen-Yee Lee, Asst. Prof., Environmental Chemistry
    (FY 2004, 2005 and 2006)
  • Juan C. Noveron, Asst. Prof., Chemistry (FY 2004,
    2005, 2006)
  • John Walton, Prof. of Environmental Engineering
    (FY 2004)
  • Jianging Zhang, Asst. Prof, Biology (FY 2004)
  • Rodrigo Armijos, Clinical Research Professor,
    College of Health Sciences (FY 2005),
  • Maria Amaya, Professor of Nursing (FY 2006)
  • Armando Gonzalez, Research Prof., College of
    Health Science, Pharmacy (FY 2006)
  • Jorge Ibarra, Research Professor, College of
    Health Science (FY 2006)
  • Rosana Lopes, Assist. Research Prof., Clinical
    Laboratory Sciences, CHS (FY 2006)
  • John Bretting, Assoc. Prof., Master of Public
    Administration (FY 2006)
  • William Lewis, Lecturer, Clinical Laboratory
    Sciences (FY 2006)

17
Lisa Bain
  • Determining ATP-dependent transport protein
    regulation and how this affects the metabolism,
    disposition, and elimination of drugs and
    toxicants
  • Elucidating how metals and pesticides in the Rio
    Grande are impacting aquatic and human health
  • Using cDNA arrays to ascertain what genes are
    being altered after exposure to metals and PAHs

Funded by NIH and NIEHS
18

Maria Duarte-Gardea
  • Nutrition Education During Pregnancy In Mexican
    American Women (Funding NIH/NCMHD)
  • Studying the effectiveness of a culturally
    sensitive nutrition education program in Mexican
    American pregnant women
  • Results will help design culturally sensitive
    programs to improve pregnancy outcomes
  • Health Effects Of Chronic Exposure To Fluoride In
    Drinking Water In Northern Mexico (Funding
    SCERP/ US EPA)
  • Evaluating health effects of chronic fluoride
    exposure from drinking water in adolescents
    living in Villa Ahumada, Chihuahua Mexico
  • Results may impact public policy regarding
    fluoride levels in drinking water

19

Maria Duarte-Gardea
  • A Pilot Study To Investigate the Associations of
    Fiber and Estrogen Levels In Mexican and Mexican
    American Women (Funding Center for Border Health
    Research)
  • Studying womens consumption of fiber and
    incidences of breast cancer in Mexican American
    population
  • Results may help design nutrition education
    programs focused in the prevention of breast
    cancer

20
Patrick Gurian (Community-Based Public Health
Research)
Dr. Patrick Gurian Assist. Prof. Civil Engineering
  • Patrick Gurian worked on a variety of
    community-based public health projects, mainly in
    peri-urban, low-income, disadvantaged and
    under-served neighborhoods on both sides of the
    border. 
  • Assessed household behaviors and environmental
    health conditions in targeted communities, and
    developed responsive training programs that
    emphasized train-the-trainer concepts using
    appropriate technologies, culturally-appropriate
    language, and readily affordable and available
    resources. 

In collaboration with CERM, College of
Engineering, College of Health Sciences, the Paso
del Norte Health Foundation, the Center for
Border Health Research, Johnson and Johnson, the
UT Houston School of Public Health, and the
Southwest Consortium for Environmental Health and
Policy (SCERP),
21
Community-Based Public Health Research (contd)
Dr. Patrick Gurian Civil Engineering
  • In one project he assessed the significant health
    risks of winter-time carbon monoxide poisoning in
    Ciudad Juarez (annually more people died of CO
    poisoning in Juarez than in all the United
    States) and helped design an appropriate and
    effective public health outreach program.  In
    areas without water service he assessed small,
    multi-household water treatment systems as well
    as solar composting toilets and other waterless
    onsite sanitation systems.   

22
Wen-Yee Lee (Env. Chemistry)
  • Dr. Lee studies fate and transport of persistent
    organic pollutants (POPS) in soil, air, and
    water/sediment, with a special emphasis on the
    impact of dietary and non-dietary exposure to
    POPs on public health.
  • Mechanism of plant uptake of POPs.
  • Phytoremediation/Bioremediation for POPs
  • Current Funding
  • Department of Energy
  • SCERP/EPA
  • Significance
  • POPs persist in the environment, bioaccumulate
    through the food chain, and have
    endocrine-disrupting and other toxic effects on
    biota. On-going efforts are focus on
    understanding the cycling of POPs in the
    environment and their impact on human health.

Wen-Yee Lee, Ph.D. Env. Chemistry Assistant
Professor
23
Juan Noveron (Gene Capsules for DNA Vaccines)
  • Development of novel metal-mediated gene
    transfection systems for eukaryotic cells.
  • These gene-delivery nanosystems will have
    applications towards a rapid and cost-effective
    production of vaccines.

Juan C. Noveron, Ph.D. Assistant
Professor Chemistry
Lizanell Colbert Coldwell Foundation
Grant American Chemical Society Petroleum
Research Grant Award Stanford Synchrotron
Radiation Laboratory Award National Institute of
Health (GM66504-01)
24
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25
Dr. John Walton (Env. Science Eng.)
  • Correlation of Ambient Particle Composition with
    Cytokine Induction in Cultured Lung Cells
  • EPA-funded project with Univ. of Utah
  • Integrated field ambient sampling and cell
    culture laboratory study
  • Particulate matter in the Paso del Norte air shed
  • Do chemical speciation measurements of ambient
    particulate matter (PM) correlate with cell
    culture assays used to assess the ability of
    particles to induce pro-inflammatory signaling
    (cytokines) in lung cells?

John Walton, Ph.D. Civil Eng. Professor
26
Jianying Zhang (Cancer)
  • Laboratory interests include the identification
    and characterization of cancer-related antigens,
    autoantibodies to cancer-associated antigens as
    markers for cancer diagnosis, and epidemiologic
    studies relating genetic, environmental, dietary
    and lifestyle factors to the etiology of liver
    cancer in Hispanic populations.

Jianying Zhang Assistant Professor Biological
Sciences
27
Rodrigo Armijo
Immunology Molecular Biology of Infectious
Diseases
  • Community health and development
  • Prevention, treatment and control of parasitic
    and other infectious diseases
  • Development clinical/field evaluation of
    vaccines, diagnostic product, treatments
  • Dr, Armijos activities are also international

Rodrigo X. Armijos, MD, ScD Clinical Research
Professor Department of Health Promotion
"Impact of Nutritional Supplementation for
Improving the Nutritional Status, Cellular
Immnune Response, and Clinical Outcomes of
Hispanic Patients Treated for Tuberculosis with
Short-Course DOTS Therapy" NIH/NCMHD Hispanic
Health Disparities Research Center, 2004-2006.
28
Maria Amaya (Environmental Health Research)
Dr. Amayas research has focused on environmental
health and the associations with soil and air
quality in border populations. Amaya colleagues
pioneered interdisciplinary NIH funded teams at
UTEP. Her expertise is in environmental
epidemiology. She is a charter member of NIH
Community Level Health Promotion (CLHP) Review
Panel, and Wakefield Professor of Health
Sciences.
Maria Amaya, PhD, WHCNP Professor, School of
Nursing
Principal Investigator Encuentros Binational
Community Lead Project, NIEHS (R01) 1.75
M UTEP-UNM HSC ARCH Program on Border Asthma
Core Project, NIEHS (S11) 5.1 million
Project leader in externally funded projects over
2 million dollars
Contributor in externally funded projects
totaling 11.5 million dollars
29
Armando González Stuart, Ph.D.
  • Researcher in herbal medicine (phytotherapy)
  • Educating Seniors about the Risks of Polypharmacy
    and Polyherbacy in the Paso del Norte Region
    (Funded)
  • Traditional Foods and Healthy Nutrition (Funded)
  • Research interests include
  • Potential herb-drug interactions
  • Toxic plants and fungi
  • Complementary and Alternative Therapies
  • Ethnobotany

Research Prof., College of Health
Sciences Pharmacy Program
www.herbalsafety.utep.edu
30
Jorge Ibarra, MD, MPH
  • Collaborated with Dr. Robert Anders in a
    multistate pilot study on The Food Pyramid WIC
    Women Knowledge and Use. Data analysis in
    progress.
  • Collaborated with Dr. Anders in the US-MX
    Minority Health International Research Training
    Program (MHIRT). Data analysis in progress.
    Project in progress.
  • Collaborated with Dr. Robert Anders in a
    proposal, Multistate Peer Nutrition Education
    Trial among Latina WIC Participants. Funding
    Pending.
  • Collaborated with Dr. Cardenas in a letter of
    intent on RFT Effect of H. Pylori Eradication on
    Iron Levels in US-MX Border Adults. Proposal in
    progress.

Research Professor College of Health Sciences.
31
Rosana Lopes
  • Dr. Lopes works in collaboration with Dr. Delfina
    Dominguez
  • Incidence of Pertussis among Children with
    Persistent cough in the El Paso del Norte Region
    and Variation in Bordetella pertussis genes
  • Studying incidence of pertussis by analyzing
    Bordetellae isolates for gene polymorphisms
    encoding two virulence factors pertactin (prnA)
    and pertussis toxin (ptxA)
  • This research is in progress and would provide
    epidemiological data for the identification of
    pertussis cases and prevention of the infection.

Delfina C. Domínguez, Ph.D., Associate Prof.
Clinical Lab. Sciences
Rosana Lopes, PhD Research Assist.
Prof. Clinical Laboratory Sciences
Collaborators Erik L. Hewlett, MD, UVA Gilbert
A. Handal, MD, Texas Tech HSC Armando Campos,
MD, IMSS
32
John Bretting
  • Specialized training Women and Politics, Race
    and Ethnic Politics, Research Designs, Survey
    Research Methods, Field Research Methods, and
    Intergovernmental Relations.
  • Development of Social Census indicators for El
    Pasos El Segundo Barrio including measures for
    a US/Mexico borderland communitys health care,
    social well-being, and economic well-being.
    Co-director Spring 2006 PAD 5367-
  • Capstone Experience El Segundo Barrio and La
    Fes Community Development Corporation An
    Analysis of Current Conditions, Strengths, and
    Opportunities including implementation and
    analysis of basic social census indicators.

Assoc. Prof., Master of Public Administration
Program Institute of Policy and Economic
Development
33
Summary
  • The goals and objectives of the Border Health
    Research funding program are being met, thus
    helping the University continue building its
    Health-related programs
  • New opportunities have arisen and have been used
    to leverage university resources to increase
    capacity, breadth, and quality of border health
    research and education programs.
  • Also, additional new faculty have been recruited
    that have brought to UTEP, not only new federally
    funded grants, but the opportunity to build major
    competitive research programs with special focus
    on border health issues.
  • These new acquisitions have prompted UTEP to
    increase the capacity and quality of its research
    facilities and administrative infrastructure to
    support research and related educational
    activities (e.g., the new biosciences facility).

34
Summary
  • The purpose of providing support for public
    service related to health and environmental
    problems that disproportionately affect Hispanics
    and residents in the U.S./Mexico Border Region
    are being met
  • UTEP is responding to the regions critical need
    for healthcare professionals by establishing a
    number of health professions education program.
  • To complement its education endeavors, and in
    consideration of the potential for growth and
    development of a local healthcare industry to
    support the regions economic development, UTEP
    organized its research capabilities to provide a
    platform to launch what is now one of its most
    rapidly growing and visible areasborder health
    research.

35
Summary
  • The ability of UTEPs biomedical and behavioral
    scientists to attract major extramural funding
    from federal sources on a competitive basis to
    promote research on border health, speaks highly
    of the programs general technical excellence,
    widely focused investigative capabilities and the
    overall quality of UTEP research facilities and
    administrative support infrastructure.

36
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