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TAKEN OVER BY CSIR

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DNA sequencing based on automated sequencing protocol using fluorescently labeled dyes ... RRL-Oc-11 (Linalool rich) RRL-Oc-12 ( Methyl cinnamate rich) RRL- Og ... – PowerPoint PPT presentation

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Title: TAKEN OVER BY CSIR


1
REGIONAL RESEARCH LABORATORY JAMMU
ESTABLISHED 1941
TAKEN OVER BY CSIR 1957
In the Service of Nation for the last Six Decades
2
REGIONAL RESEARCH LABORATORY, JAMMU One of the
40 National Laboratories under Council of
Scientific Industrial Research, New Delhi
View of Main Building
3
MANDATE
TO CARRY OUT RD WORK WITH A VIEW TO BOOST
THE INDUSTRIAL DEVELOPMENT OF NORTH-WESTERN
REGION OF THE COUNTRY. TO HELP IN OPTIMAL
UTILISATION OF NATURAL RESOURCES OF THE
REGION. TO EXPLORE AND EXPLOIT HITHERTO
UNTAPPED RESOURCES OF THE REGION. TO
PROVIDE CONSULTANCY, TESTING AND EQUIPMENT
DESIGN / FABRICATION FACILITIES TO
ENTREPRENEURS, INDUSTRIAL ESTABLISHMENTS AND
GOVERNMENT DEVELOPMENTAL AGENCIES.
4
CORE R D AREAS
Bio-prospecting of natural molecules
Natural Products ( Cultivation , Improvement
and Processing) Natural
Products Chemistry Microbial
Biotechnology
5
VISION
  • Based on the expertise, manpower, infrastructure
    and data-base developed in various areas, it is
    our firm endeavour to develop Regional Research
    Laboratory, Jammu as a NATIONAL INTERNATIONAL
    CENTRE OF EXCELLENCE in the areas of its core
    competence.


6
ORGANISATIONAL CHART
External Agencies
DG CSIR
PME Industrial Liaison
Director
Research Council Management Council
R D Groups
Technical Service
Information
Business Development Project Planning Monitoring
Evaluation Industrial Liasion Patent
Publication Management Photography, Art
Museum
1.Chemical Engg. Design 2. Workshop 3.
Instrumentation 4. Glass Blowing 5. Herbarium
Crude Drug Repository
1. Prospecting Microbial Biodiversity (Biotechno
logy) 2. Natural Product Chemistry i
Prospecting Biodiversity for its Chemistry
and bioactivity ii Process Development
iii Upscaling Lab Processes iv Quality
Control Assurance v Catalysis 3.
Bioavailability Enhancers 4. Botanical
Sciences i Conservation ii Crop
Improvement iii Survey and Taxonomy 5.
Information Technology 6. Rural Technologies
1. Library 2. Computer Centre 3. Bioinformatics
Centre 4. Knowledge Network on Medicinal
Plants
Other Centres
Administration
1. Regional Research Laboratory, (Branch)
Srinagar 2. Experimental Farms
(Kashmir) (Jammu)
1. Establishment 2. Finance Accounts 3.
General and Bill Section 4. Personal Cell 5.
Stores Purchase 6. Security 7. Construction
Maintenance
Other Essentials
1. Dispensary 2. Canteen 3. Guest House 4. School
7
HUMAN RESOURCE
Scientists 96 Technical Officers 74 Ph.Ds
137
Manpower Strength
Budget
Rs.135 Million Externally Funded Projects
8
Major strengths of RRL
  • Agrotechnology packages micropropagation
    protocols for medicinal aromatic crops
  • Natural dyes and pigments
  • Phytopharmaceuticals Essential oil
    products
  • Technologies for drugs and drug
    formulations
  • Conversion of terpene hydrocarbons to
    useful perfumery chemicals
  • Microwave based process for chemical
    conversion / extraction
  • Kinetic resolution of selected racemic
    chiral drugs

9
Services and facilities offered
  • Identification /authentication of medicinal and
    aromatic plants
  • Quality control and standardization of herbal
    drugs
  • Pharmacological evaluation of natural /synthetic
    products
  • Industrial enzymes for chiral resolution,
    biotrans- formation and the production of
    organic acids
  • Chemical bacteriological testing of potable
    water, food products, herbal drugs and
    municipal wastes.
  • Analysis of mineral and coal.

10
Other services to the clients
Contract research facility. Consultancy
services in the areas of core competence. Serv
ice like testing, analysis, design, validation
etc. Internet connectivity for online search
facility. Pilot plant usage on rental.
11
Analytical and Testing facilities
For Drugs ,Pharmaceuticals, Phytochemicals
Essential oils
PMXNMR, SUPERCON, FTNMR, GC,GC-MS, LC-MS-MS, IR,
UV/VIS, Elemental Analyzer, Transmission
Scanning Electron Microscopy
LC-MSn
NMR, 60 90 200 MHZ
HPLCs - 8 Nos.
ROBOTIC LIQUID HANDLING SYSTEM
GLCs - 3 Nos.
12
Analytical and Testing facilities
For Drugs ,Pharmaceuticals, Phytochemicals
Essential oils
SEPBOX ( Separation Box), FT NMR 500MHZ in pipe
line
For Multidimensional Chromatography SEPIATEC,
Germany
13
Core competence in Molecular Biology
DNA fingerprinting of microorganism based on
RAPD, RFLP Physical and molecular plasmid DNA
characterization of microorganism Genome
sizing and gene location based on
transpogenesis. Use of DNA probes for the
identification of specific genes. DNA sequencing
based on automated sequencing protocol using
fluorescently labeled dyes Identification of
genes based on P C R technique Identification of
bacteria based on molecular markers like 16S r
RNA typing
14
BIOTECHNOLOGY PROJECTS
PLANT BIOTECHNOLOGY
MICROBIAL DIVERSITY GENOMICS
Detection of human pathogens from regional fruits
RFLP DNA FINGERPRINTING IN SELECTED MEDICINAL
PLANTS
KLEBSIELLA ASPERGILLUS FLAVUS
RAPD PROFILE IN SELECTED RHIZOBIUM STRAINS
Tn5 TRANSPOGENESIS
Genome sizing by PFGE
BIOPROCESS DESIGN ENZYME REACTORS
CROP TREATED WITH TRICHODERMA RHIZOBIUM
MASS PRODUCTION OF BIOFERTILIZERS BIOCONTROL
AGENTS
15
Prospecting Microbial Biodiversity of N.W.
Himalayas.
  • Screening of Microbial Biodiversity for
    extremophiles with particular emphasis on
    thermophiles.
  • Identification of potentially useful Microbes
  • Maintenance and preservation of selected
    microorganisms.
  • Screening of selected Thermophiles for their
    potential as Lipases, Esterases, Acylases,
    Isomerases, Oxido- reductases etc.
  • Kinetic resolution studies of selected target
    molecules using above enzymes.

16
Prospecting Microbial Biodiversity of N.W.
Himalayas
  • Location, Cloning and Hyper-Expression of
    gene(s) encoding these enzymes in suitable host
    microorganisms
  • Screening for pathogenic microorganism using
    specific gene probes.
  • Large scale production by fermentation using up
    to 4M 3 bioreactors and their down stream
    processing and purification of the selected
    thermophilic enzymes.

17
Activities on Medicinal Plants/Herbal Drugs
Resource Status of Medicinal plants
Agrotechnology of prioritized plants Tissue
culture protocols of prioritized plants Concept
of organic culture as value Standardization
using chemical and molecular markers Design,
fabrication and commissioning of pilot plants
18
MEDICINAL PLANT SECTOR
ADAPTOGENS
HEPATOPROTECTIVE/ IMMUNOMODULATORY
ANTIDEPRESSANT
WITHANIA SOMNIFERA
SWERTIA CHIRATA
HYPERICUM PERFORATUM
PICRORHIZA KURROA Tissue culture Field view
POLYGONATUM CIRRHIFOLIUM
19
Selected Medicinal Plants for commercialization
Acorus calamus Picrorhiza kurroa Discorea
composita Podohyllum hexandrum Discorea
deltodiea Rheum emodi Echinacea
angustifolia Swertia chirayita Hyoscyamus
niger Valeriana wallichii Hypericum
perforatum Viola odorata Inula
racemosa Withania somnifera Nardostachys
grandiflora Bacopa monniera
20
AROMATIC PLANT SECTOR
BREWERY, DETERGENT AROMA INDUSTRY
CLARY SAGE
HOPS
RRL-CN-5
RRL-CKP-25
RRL-CC-1
LAVENDER
21
Selected Aromatic Plants for commercialization
Cymbopogons CKP- 25 (Citral rich) RRL-Cn- 5 (
Geraniol rich)
Ocimums RRL-Oc-11 (Linalool rich) RRL-Oc-12 (
Methyl cinnamate rich) RRL- Og-!4 ( Eugenol
rich) Mentha M. piperita M.spicata M. citrata
22
Screening for the Development of new indigenous
enzymes for commercialization
New enzymes
Drug intermediates
Bio-organic chemistry RD Programme
Kinetic Resolution Studies
Drugs
Fine chemicals
Biomolecules
Chemo-enzymatic syntheses
Essential oils
Biotensides
23
HIGHLIGHTS
NEW ENZYMES
  • OXIDO-REDUCTASE
  • RRL-281
  • LIPASES
  • RRL 1
  • RRLY-15
  • RRL-1789
  • RRL-191
  • RRL-BB-1

RESOLUTION PROCESSES
  • ANTIDEPRESANTS
  • ANTI-INFLAMMATORY
  • ACE INHIBITORS
  • AGRO CHEMICALS

BIOMOLECULES
  • TERPENES
  • FINE CHEMICALS
  • NATURAL PRODUCTS

24
PLANT BASED BIOAVAILABILITY ENHANCERS
Based on Traditional Knowledge Base RRL Jammu
Conceptualized and Developed a Novel Approach for
Enhancement of Drug Bio-availability
CLASSICAL EXAMPLE
  • Plant extract or activity guided defined
    fractions or single isolated molecules derived
    thereof as drug bio-availability enhancers.
  • Piper longum (long pepper) extract.
  • Piperine - pure alkaloid isolated from pepper -
    ( A wonder molecule)
  • Pharmocological Activity
  • Anti-inflammatory
  • Anti- Fertility
  • Hepatoprotective
  • Stimulates serotonin synthesis in Brain
  • First Isolation 1877
  • First synthesis 1882
  • Stereoselective synthesis 1970, 1981

25
Prospecting of natural molecules
  • Chemical markers standard compounds
  • Phytochemicals
  • Flavour fragrances
  • Synthetic analogues of bioactive molecules
  • Colchicine Colchicosides from seeds of Gloriosa
    superba
  • Silymarins from Silybum marianum
  • Sennosides from Senna leaves

26
PLANT BASED DRUGS AGAINST TARGETTED DISEASES
  • Immunorestorative composition based on single
    bioactive chemical entity from RJM/0100/P01.
  • Antioxidant and free radical scavenging
    composition from RJM /1173/P05
  • Chemically standardised, Antidiabetic (Type II)
    product from 0511/P12 undergoing open
    multicentric clinical trials.

27
ESSENTIAL OIL PRODUCTS
AN IMPROVED PROCESS FOR THE PRODUCTION OF
CITRONELLOL
A PROCESS FOR THE SIMULTANEOUS EXTRACTION OF
ESSENTIAL OILS AND RUTIN FROM PLANTS.
AN IMPROVED PROCESS FOR THE PRODUCTION OF
E-ANETHOLE
AN IMPROVED PROCESS FOR THE PRODUCTION OF
THYMOL
28
DESIGN FABRICATION JOBS EXECUTED
A multipurpose mini fermentation pilot plant
commissioned at number of places
Hops drying Kilins commissioned in HP
Aroma Chemical Plant commissioned at Ho Chi
Minh City, Vietnam
40000 L scale D-gluconates production plant
commissioned
for M/S Prathistha Industries Ltd.Hyderabad
29
DRUGS PHYTOPHARMACEUTICALS
An Improved Process For The Preparation of
9-Nitro-(20S)-Camptothecin From Natural
Camptothecin An improved process for the
preparation of 10-Hydroxycamptothecin using
Aspergillus ochraceus Microbial transformation
of Taxoids to 10-Deacetylbaccatin-III Chemical
Standardisation of Herbal Drugs as Adaptogens/
Immunomodulators An improved process for
isolation of Colchicine and Colchicoside Synergi
stic formulation possessing antidepressant
activity from Hypericum perforatum
30
BIO-INOCULANTS
  • Bio-fertilizers
  • Rhizobium , Azetobactor ,
  • Azospirillium and Phosphate
  • solubilising organisms
  • Bio-control Agents
  • Fungal antagonists (AGAINST
  • ROOT-ROT FUNGI)

A view of untreated (control) field of Pea
A view of biofertilizer biocontrol agent
treated field of pea
31
Industrial Partners..
  • M/s Nicholas Piramal Ltd., Mumbai for the
    development of end to end technology on Hypericum
    perforatum for the development of mild anti
    depressant formulation conforming to USP both for
    captive and International market.
  • M/s Lupin Laboratories Ltd., Mumbai for the
    development of hepatoprotective and anti
    diabetic marketable products of plant origin.
  • M/s Dhawan International Ltd., Mumbai for the
    production of varied herbal products.

32
Industrial Partners
  • M/S Zydus Cadila Healthcare Ltd., Ahmedabad for
    the Resolution of racemic drugs by microbial
    enzymes.
  • M/S Bharat Biotech International Ltd. Hyderabad
    for the Development of novel immuno-adjuvants- as
    vaccines.
  • M/S Andel Equipment Pvt. Ltd, Mohali for Design
    fabrication of bioreactors
  • M/S Pratihista Industries Ltd, Secundrabad, for
    the Production of gluconate salts through
    fermentation process

33
Latest in RRL
Supported by Ministry of HRD
Mega Project on Aromatic Herbal Farming for
empowerment of Women
by RRL, Jammu J K Ex Services League
10,000 women to be involved
34
Knowledge Network on Medicinal Plants and
National Center for Training Technology Transfer
GOI - UNDP sponsored
Scope of Activity
Preparation of database on herbal
drugs. Networking with other data
bases. Preparation of Pharmacopoeial
Monographs To bring developing countries on the
net work for holding e-conferences in cyber
space. To hold TCDC training workshops in the
area of herbal drugs . To evolve strategies
for filling up gap areas in the field of
herbal drugs development.
www.herbalnet.org
35
New Millennium Indian Technology Leadership
Initiative ( NMITLI )
A Path Setting Scheme instituted by CSIR
Partners in the project
Industrial Partners
University Partners
Institutional Partners
36
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37
DBT-SPONSORED PROJECTS
  • ESTABLISHMENT OF GENE BANK OF MEDICINAL PLANTS OF
    N-W HIMALAYAS
  • IN VITRO PROTOCOL STANDARDISATION DEMONSTRATION
    OF PLANTS OF AGRICULTURE / HORTICULTURE
    IMPORTANCE
  • STUDIES ON THE MICROBIAL DIVERSITY OF
  • N-W HIMALAYAS
  • MOLECULAR CHARACTERIZATION OF SELECTED FUNGAL
    BACTERIAL SPP. OF AGRICULTURE IMPORTANCE
  • ESTABLISHMENT OF SUB-DIC UNDER BITS

38
DST- SPONSORED PROJECTS
  • RESOLUTION OF RACEMIC DRUGS BY MICROBIAL
  • ENZYMES
  • KINETIC RESOLUTION STUDIES OF ANTI-DEPRESSANT
  • DRUG INTERMEDIATES
  • PROCESS DEVELOPMENT SCALE-UP OF RESOLVED DRUG
  • INTERMEDIATES
  • STUDY OF IDENTIFIED PLANT BASED IMMUNO-
  • MODULATORS AS POTENTIAL ADJUANTS FOR
  • VACCINES
  • DEVELOPMENT OF NOVEL ADJUANTS

39
ISM-SPONSORED PROJECTS
MICROBIAL DECONTAMINATION OF AYURVEDIC/ UNANI
DRUGS BY MICROWAVE ENERGY TO ESTABLISH STANDARD
PROTOCOL FOR DECONTAMINATION OF AYURVEDIC/UNANI
DRUGS BY MICROWAVE TREATMENT DEVELOPMNT OF
AGROTECHNOLOGIES CULTI VA- TION OF MEDICINAL
PLANTS TO DEVELOP STANDARDISE THE
AGROTECHNOLOGIES CULTIVATION PRACTICES OF
IMPORTANT MEDICINAL PLANTS BEING USED IN
AYURVEDIC DRUG FORMULATIONS
40
ICMR - SPONSORED PROJECTS
APPLICATION OF PRIMARY MONOLAYER CULTURES OF RAT
HEPATOCYTES IN THE DEVELOPMENT OF
HEPATOPROTECTIVES FROM MEDICINAL PLANTS
DEVELOPMENT OF STANDARDS OF SELECTED
THERAPEUTICALLY IMPORTANT MEDICINAL PLANTS
PREPARATION OF MONOGRAPHS THEREOF
ICMR-CENTRE FOR QUALITY CONTROL, STANDARDI-
ZATION FORMULATION OF TRADITIONAL HERBAL DRUGS
DEVELOPMENT OF DNA FINGERPRINTS AS MOLECULAR
MARKER IN SELECTED MEDICINAL PLANTS
41
Network R D Project with other CSIR Institutes
A New Initiative.
  • Newer Scientific Herbal Preparations for
    global positioning
  • Molecular biology of selected pathogens for
    developing drug targets
  • Globally competitive chemical processes and
    products
  • Medicinal Plant Chemotypes for enhanced marker
    and value added compounds
  • Coordinated Programme on Catalysis Catalysts
  • Positioning Indian nutraceuticals and
    neutrigenomics in Global Platform
  • Asthmatic and allergic disorders mitigation
    mission
  • Developing Cells and Tissue Engineering

42
Network R D Project with other CSIR Institutes
A New Initiative.
  • Designing animals and plants as bio-reactors for
    proteins other products
  • Toxicogenomics of polymorphism in Indian
    population to industrial chemicals for
    development of biomarkers
  • Drug target development using in-silico
    biology
  • Natural, nature identical or similar
    biomolecules
  • Developing Green Technologies for Organic
    Chemicals
  • Exploration and Exploitation of Microbial Wealth
    of India for novel compounds and
    biotransformation process
  • Infectious Diseases Handling, Storage and
    Research Facilities

43
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