Greater China Consortium for Study of Hepatitis B Virus Immunopathogenesis and Immunity GCCSHBVII

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Greater China Consortium for Study of Hepatitis B
Virus Immunopathogenesis and Immunity
(GC-CS-HBVII)

• Greater China
• Non-profit
• Non-discriminatory
• Non-political

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Background
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Worldwide Prevalence of HBV and Incidence of HCC
World prevalence of HBV carriers
Annual incidence of primary HCC
HBsAg carriers-prevalence lt2 27 gt8 Poorly
documented
Cases/100,000 population 13 310 10150 Poorl
y documented
WHO 2003
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Hepatitis B Related Death in China
gt85 related to HBV infection
He et al. NEJM 2006
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HBV Host Relationship
Host genome profile
Immune system

• SNPs

• Viral kinetics
• HBV genotypes mutants

HBV

• Gene expression

Disease progression with necroinflammation
Rx responder
Resolution
Rx non-responder
Liver Cancer
Rx-treatment
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Our Vision
Perfect tailor made therapy for chronic
hepatitis B
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Our Mission

• To offer innovative integrated molecular
  diagnostic and research approaches for the
  clinical management of chronic hepatitis B.

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Goals of HBV study

• To identify predictors of disease progression and
  treatment response
• To develop new therapies for viral hepatitis and
  liver cancer
• To promote high quality research into viral
  hepatitis
• To consolidate Greater China partnerships with
  clinical, genetic, virological and immunological
  expertise
• To develop a comprehensive bioinformatics
  resource for the management of chronic hepatitis B

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Founding Institutes
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Partnerships
Clinical GKK Lau, CM Lo, R Poon, CK Hui The
University of Hong Kong, Hong Kong
Immunology Fu Gao Chinese Academy of Sciences
Xiao-ming Gao Peking University Health Science
Centre Fang-ping Huang The University of Hong
Kong, Hong Kong Fu-Sheng Wang Beijing Institute
of Infectious Diseases
Virology Zhaung Hui Peking University Health
Science Center, Beijing
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Genetic study William Mak, Pak Sham Genome
Research Centre, HKU
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Milestones