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The Dublin Molecular Medicine Centre A Model for Translational Research

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Clinical Oncology. Genetics. Molecular Medicine. Oncology. Pathology. Psychiatry. Public Health Medicine and Epidemiology. Surgery ... – PowerPoint PPT presentation

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Title: The Dublin Molecular Medicine Centre A Model for Translational Research


1
The Dublin Molecular Medicine CentreA Model
for Translational Research
2
The Unique Irish Environment
  • Small country (4million inhabitants)
  • Large Pharma Presence
  • Ireland is the second exporter of pharma products
    in the world
  • Homogeneous Gene Pool
  • The 90s was the first decade in 400 years that
    immigration gt emigration and that the GDP
    increased
  • Centralised patient consultation for serious
    diseases
  • The 6 major teaching hospitals in Dublin capture
    gt50 of the total population
  • Recent government investment in research
    infrastructure (buildings ,equipment,people)
  • Digital environment (EHQ for Intell,Dell,HP,MS,)

3
Academic Environment
  • Royal College of Surgeons in Ireland
  • Established in 1784
  • incorporating
  • Institute of Biopharmaceutical Sciences
  • Focused on
  • - Cardiovascular Disease
  • Angiogenesis
  • Inflammation
  • - Cancer
  • - Neurodegenerative Diseases
  • using
  • Bioinformatics (with NUIM, Ireland)
  • Irish Gene Bank (SurgGen)
  • Probiotics (with UCC, Ireland)
  • Proteomics(SFI Centre)
  • Trinity College Dublin
  • Established in 1592
  • incorporating
  • Institute of Molecular Medicine (St. Jamess
    Hospital / TCD)
  • Fucused on
  • Oesophageal Cancer
  • Haematological Malignancy
  • Infectious Diseases
  • Inflammation
  • Genetics of Neuropsychiatric diseases
  • in association with
  • Transgenic Research Centre
  • Nanotechnology Research Centre
  • TCIN

University College Dublin Established in
1851 incorporating Conway Institute Focused
on - Neuroscience - Host Defence Immunity -
Vascular Disease - Prostate/Breast Cancer
using Structural Biology Proteomics Array
Technologies
4
Bench to Bedside Research
5
RCSI/TCD/UCD Research Centres in Molecular
Medicine
Teaching Hospitals and CRC/GRUs
6
A Molecular Medicine Community
Programme for Human Genomics 45M
PRTLI Cycle 3
Biopharmaceutical Science Network (Lead by Royal
College of Surgeons in Ireland) 9.4M
Dublin Molecular Medicine Centre 27M
PRTLI Cycle 2
Institute for Molecular Medicine 0.5M
Conway Institute for Biomol Biomed Res. 61M
Institute of Biopharmaceutical Sciences 11M
PRTLI Cycle 1
Other Irish Universities
Trinity College Dublin
University College Dublin
Royal College of Surgeons in Ireland
7
The Dublin Molecular Medicine Centre
  • The DMMC is..
  • An Independent Company (not for profit)
  • CEO reporting to a board of directors
  • BoD is Tri-Institutional, includes business
    focussed individuals and is chaired by Dr. Pat
    Gage (ex RD Head for Wyeth)

8
Goal of DMMC Research
IMPROVEMENTS IN HEALTHCARE
Modern Infrastructure State of the Art
Technologies
Education of Biomedical Professionals
Links with Pharma
Basic Research
New companies
Clinical Translational Research
9
The Translational Research Space
10
The Translational Research Space
Academia
Clinical
DMMC
Biotech Pharma Industry
11
Prostate Cancer Research Consortium
12
Prostate Cancer Research Consortium
Mater Misericordiae
St James
St Vincents
St Lukes
Tissue Processing Unit (Genome Resourse Unit)
Departments of Biochemistry Chemistry Clinical
Oncology Genetics Molecular Medicine Oncology Path
ology Psychiatry Public Health Medicine and
Epidemiology Surgery
Durkan Institute Institute of Molecular
Medicine (Trinity)
Conway Institute (UCD)
13
Lead Consortium Members
  Surgeons Professor John Fitzpatrick Mater/
UCD Mr David Quinlan St Vincents/UCD Mr Tom
Lynch St James/Trinity Pathologies Dr
Conor OKeane Mater/UCD Dr Tom Crotty St
Vincents/UCD Professor Eoin Gaffney St
James/Trinity  Clinical Oncologists Professor
Donal Hollywood Trinity/St Lukes/St James Dr
John McCaffery Mater Radiotherapist Dr
Michael Maher Mater     Scientists Dr
William Watson UCD/Mater Professor Mark
Lawler Trinity/St James Professor Steve
Pennington UCD/DMMC Dr Karen Woodson/Dr Joe
Tangrea NCI Dr Amanda McCann UCD Dr Daniela
Zisterer Trinity Dr Declan Gilheany UCD Pr
ofessor Joe Duffy ST Vincents/UCD Dr Peter
Doran UCD/Mater   Public Health Medicine
and Epidemiologist Dr Patricia
Fitzpatrick UCD Psychiatrist Dr John
Sheehan Mater
14
Prostate Cancer Research Consortium Scientific
Programme
1
2
3
4
Collection
Target Identification
Molecular Classification
Clinical Evaluation
Tumour Bank
Therapeutics
Phase 1 Clincal Trials
Genomics
Proteomics
Diagnostics
Apoptotic Resistance
Attitude Survey
15
Resource for Psychoses Genomics Ireland
  • TCD/UCD/RCSI and associated hospitals
  • Funded (1.8 million) Wellcome Trust
  • Academic lead Professor Michael Gill (TCD,SJUH)

16
Aims Sample Collection
  • To ascertain and characterise a sample of
    1200-1500 subjects with a Major Psychotic
    disorder to establish a resource for use by the
    scientific community
  • Collect parental DNA and selected phenotypic
    information for a subset of cases (sub-sample of
    300-400 trios)
  • Collection to take 2 years

17
Sample Collection
  • At least 5 clinical teams
  • Belfast
  • Cork
  • Borders/North West
  • Dublin/South East
  • Dublin/North East
  • Wide geographical spread throughout the island of
    Ireland
  • Biomaterials sent to central facility (GRU) for
    banking
  • Collection to begin in January 2005

18
Ongoing
  • More programmes of this type in pipeline
  • Hepatitis C
  • Type II Diabetes
  • Upper GI tract cancers
  • Rheumatoid Arthritis
  • Breast Cancer
  • Colon Cancer
  • Epilepsy

19
Challenges
  • Critical Mass
  • Focus
  • Technology
  • Disease Area
  • Geography (virtual organisation)
  • Sustainibility
  • Individual Vs collective mindset
    (Instition/Individual)

20
Opportunities
  • Translational research
  • Create recognised centre of excellence in this
    domain over a ten year time frame (2010)
  • European projects. Links with North America
  • Identify similar (size , technologies, diseases)
    centres elsewhere and build partnerships built on
    science (not politics)
  • We must increase our interaction with industry
    and venture capital sources

21
Thoughts from yesterday
  • Do some benchmarking but create your own model
    that will work for Ottawa .
  • Everywhere is different.
  • In Ireland a top down approach does not work
  • Need buy-in from the top but work up from the
    bottom
  • Focus on strengths and decide on niche areas
  • Link up with International,like minded centres
  • Need money.
  • No-one will move without it
  • Be strategic.
  • Position yourselves for the world in 5-10 yers
    time
  • It is a global competition

22
Summary of DMMC Strategy
  • Defragment existing environment to create
    internationally competitive trans-institutional
    clusters
  • Develop collaborations that accelerate the
    translation of fundamental research to clinical
    application
  • Assemble cutting-edge technologies that advance
    fundamental research bioresources that allow
    specific hypotheses to be tested
  • Partner with several leading international
    centres to build a strong network that has Dublin
    at the centre
  • Develop multi-disciplinary education curricula
    that is business-focused and allows career-long
    learning
  • Develop a commercialisation strategy partnering
    with Pharma and creating new companies based on
    home grown knowledge

23
DMMC Directorate
  • DMMC Directorate Office
  • Newman House
  • 85 St Stephens Green
  • Dublin 2
  • Tel 716 5560
  • Fax 716 7298
  • E-mail info_at_dmmc.ie
  • www.dmmc.ie
  • Chief Executive Pierre Meulien
  • Executive Assistant Carmel Ní Luanaí
  • Education Information Officer Mark Watson
  • Financial Controller Peter OHara
  • Programme Manager Paul Harkin
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