Erythropoietin Retrospective Study - PowerPoint PPT Presentation

1 / 15
About This Presentation
Title:

Erythropoietin Retrospective Study

Description:

Erythropoietin Retrospective Study – PowerPoint PPT presentation

Number of Views:244
Avg rating:3.0/5.0
Slides: 16
Provided by: scottki8
Category:

less

Transcript and Presenter's Notes

Title: Erythropoietin Retrospective Study


1
ErythropoietinRetrospective Study
  • Recombinant Human ErythropoietinDogs and Cats
    with Naturally Occurring Renal Failure

Dr. Dianne E. Kittrell, DVMDr. Cathy Langston,
ACVIMThe Animal Medical CenterJanuary 30, 2003
2
Retrospective Overview
  • Background Information
  • Population Signalment
  • Results and Discussion
  • Case Study Examples

3
Background Information
  • The Problem Anemia of renal failure
  • Both Human recognition and animal incidence
  • anemia of human CRF, recognized 1836
  • Anemia present 35 feline CRF, reported1992
  • Main Causes Pathogenesis of anemia
  • Inadequate erythropoietin
  • Limits red blood cell production
  • shortened red cell survival, recognized 1953
  • platelet dysfunction, recognized 1956
  • Iron deficiency and uremic bleeding

4
Background Information
  • The Solution r-HuEPO
  • Structurally conserved among species
  • R-HuEPO suitable replacement, 1985
  • Efficacy established in animals, 1998
  • The Objective
  • Evaluate resolution of anemia and resultant
    complications of erythropoietin treatment

5
Population Signalment
Canine (17)
Feline (83)
6
Adverse Effects of Treatment
  • Antibody formation
  • Hypertension
  • Seizure activity
  • Polycythemia
  • Pain on injection site

7
Population Response to Therapy
Indeterminate (27)
Responsive (57)
Unresponsive (16)
Conclusion Population sample demonstrates strong
response to therapy with limited complications
8
Median Survival from EPO Start
plt0.0001
9
Canine Median Survival from EPO
plt0.0001
10
Feline Median Survival from EPO
plt0.0001
11
Case Study Comparisons
Case 715009Alex Steinbuch, Feline Siamese MC
Case 714687Sylvester McGee, Feline DSH MC
12
Case 01 Optimal Response
Case 715009Alex Steinbuch, Feline Siamese MC
13
Case 02 Antibody Complications
Case 714687Sylvester McGee, Feline DSH MC
14
Concluding Remarks
  • Evidence suggests that erythropoietin treatment
    positively impacts animals quality of life
  • Final comments
  • Further research
  • Research Citations

15
References
  • Cowgill LD, James KM, Levy JK, Browne JK, Miller
    A, Lobinger RT, Egrie JC. Use of recombinant
    human erythropoietin for management of anemia in
    dogs and cats with renal failure. JAVMA, Vol
    212, No 4, Feb 15, 1998.
  • Osborne CA, Lulich p, OBrien TD, Polzin DJ.
    Feline renal failure Questions, answers,
    questions. The Compendium, Vol 14, No 2, Feb
    1992.
  • Eschbach JW, Egriem JC, Michael RD, Browne JK,
    Adamson JW. Correction of the anemia of
    end-stage renal disease with recombinant human
    erythropoietin. The New England Journal of
    Medicine, Jan 8, 1987. pp.73-78
  • Eschbach JW, Haley NR, Adamson JW. The anemia of
    chronic renal failure Pathophysiology and
    effects of recombinant erythropoietin.
    Complications in chronic renal failure. Contrib
    Nephrology. Vol 78, 1990. pp.24-37
  • Rrslev AJ. Erythropoietin. The New England
    Journal of Medicine, May 9, 1991, Vol 324, No 19.
    pp. 1339-1344
Write a Comment
User Comments (0)
About PowerShow.com