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Folie 1

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Friedel Crafts reaction. Fries rearrangement. High pressure hydrolyses. Knoevenagel ... Michael addition. Wittig reaction. Wurtz coupling. and more... Benzyl ... – PowerPoint PPT presentation

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Title: Folie 1


1
...is the Fine Chemical business of International
Chemical Investors Group (ICIG)
2
ICIG represents 15 operating companieswith
3,000 employees and sales of 600 mio
Profile
  • International Chemical Investors is a privately
    held investment group focusing on mid-sized
    chemicals businesses, preferably subsidiaries of
    large corporations operating in competitive
    environments, which were considered non-core and
    acquired at low multiples
  • Strengths Narrow focus on chemicals, well
    invested plants in favorable locations,
    international orientation, leading positions in
    niche markets, experienced employees trained in
    major chemical corporations, best practice across
    all activities
  • Operating Companies 17
  • Sales 650 million
  • Employees approximately 3,000
  • Locations 19 manufacturing plants, 11 in
    Germany, 3 in the United States, 2 in France, 1
    in Ireland, Italy and Poland in addition sales
    offices in Germany, the United States,
    Switzerland, Belgium, Italy, Spain, the United
    Kingdom and China
  • Heritage of Operating Companies RAG / RÜTGERS,
    Akzo Nobel / Acordis, Albemarle, Cambrex,
    Clariant, Solvay, AstraZeneca, Mitsubishi

3
ICIG is a long term investor exclusively
focussedon chemicals and chemical related
industries
Strategy
  • Investments in chemicals or chemicals related
    industries only
  • Long term holding approach, patient and
    knowledgeable investors
  • Flexible and fast transaction structuring and
    closing ability
  • Platform potential for additional add-on
    acquisitions preferred
  • Standalone operations but best practice exchange
    across portfolio companies
  • State of the art monitoring and control systems
  • Administrative services unit (IT, accounting,
    insurance, credit etc.), providing services to
    group operating companies, if appropriate
  • Attractive management and employee incentive
    programs

4
ICIG can offer its customers the whole
pharmaceutical (and agrochemical) value chain
Fine Chemicals Oper-ations
Basic Chemicals
Fine Chemicals
Advanced Intermediates non-GMP GMP
Active Ingredients
Final Dosage Form
THANN, PORT DE BOUC (F)
CORK (IRE),
PLANKSTADT
ELGIN (US), TRISSINO (Italy) GRIESHEIM, HÖCHST,
MANNHEIM
CHENOVE (F)
  • Final dosage form capacities at the Plankstadt
    site complete the elements of the pharmaceutical
    value chain within ICIG operating companies
  • Extension of offered service range to existing
    customers (One-stop shopping)
  • Sales to the pharmaceutical industry managed by
    Corden sales organisation

5
ICIG offers Fine Chemicals under those brands...
Mannheim
Fine Chemicals, Thann
Trissino
Our Customers
Elgin
Frankfurt
Port-de Bouc
6
WeylChem operates production plants in Germany
and US
7
All facilities offer a broadrange of
capabilities for Custom Manufacturing
8
ICIG Fine Chemicals Technologies and Product
Lines
Core Competencies
Support Reactions
Main product lines
Photochlorination Catalytic Oxidations Fluorinatio
n via Halex, HF or Electrochemical
Bromination Diazotization/Sandmeyer Grignard
Chemistry Ullmann coupling Allylations Enzymatic
Reductions
Alkylation/Acylation Acid chloride
formation Carbonylation Claisen
rearrangement Chlorination Diels Alder
reaction Esterification Friedel Crafts
reaction Fries rearrangement High pressure
hydrolyses Knoevenagel Michael addition Wittig
reaction Wurtz coupling and more
Benzyl chlorides Benzaldehydes Benzoyl
chlorides Carboxylic acids/esters/anhydrides Fluor
oaromatics Various organic bromides Grignard
reagents R-Mg-X Diphenyl ethers Allyl
Esters/Ethers Quinolines Acylation Products

9
Key technologies Frankfurt-Höchst
  • Side chain chlorination VP3
  • Capacity 7,500 mt/a
  • 4 Chlorination lines
  • 2 Hydrolysis lines
  • Various distillation units

10
Key technologies Frankfurt-Griesheim
  • Fluoroaromatics via Halex Exchange


Examples
11
Key technologies Miteni-Trissino
  • Benzotrifluorides

SIDE CHAIN PHOTOCHLORINATION
HALOGEN EXCHANGE
ANCILLARY TECHNOLOGIES
R1 None, Cl, F, COCl, etc.
R2 Cl,
12
Key technologies Miteni-Trissino
  • Perfluorinated derivatives

ELECTROCHEMICAL FLUORINATION

13
Key technologies Mannheim
  • Enzymatic Reduction from Ketones to chiral
    alcohols
  • substrate concentration ? 10
  • inexpensive enzyme
  • complete and quick conversion in about 6-24 hours
  • cost contribution of coenzyme lt 1 /kg product

OxI OxII substrate coupled coenzyme
regeneration OxI ? Ox II enzyme coupled
coenzyme regeneration
14
Key technologies Mannheim
  • Enzymatic reduction

(S)-3-Hydroxypyrrolidine
(S)-()-3-Hydroxytetrahydrofuran
(S)-3-Hydroxy-N-substituted pyrrolidines
(R)-4-Mercapto-2-pyrrolidone
(S)-ß-Hydroxy-? butyrolactone
(S)-4-Hydroxy-N-substituted-pyrrolidones
(S)-4-Hydroxy-2-pyrrolidone
15
Elgin Key Technologies
  • Grignard reaction products


16
Thann/ Port de Bouc Typical Molecules
Monobromo.
a-Halogenated acid derivatives
Dibromo .. or mixed halogens
?-Halogenated acid derivatives

a,?-Dihalogenated acid derivatives
17
Marketing and New Business Development Dr. John
C. Wetzel 1(803) 438 7762 john.wetzel_at_weylchem
.com Dr. Wolfgang Mueller 49 69 3800
2109 wolfgang.mueller_at_weylchem.com Dr.
Andrea Missio 39 0445 499560 andrea.missio.mi
teni.com
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