Why are Great Danes so much larger than Chihuahuas - PowerPoint PPT Presentation

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Why are Great Danes so much larger than Chihuahuas

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IGF1 (encoding insulin-like growth factor 1) partially explains why... Fig. 1. Relationships of skeletal size, SNP markers, IGF1 haplotype, and serum ... – PowerPoint PPT presentation

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Title: Why are Great Danes so much larger than Chihuahuas


1
Why are Great Danes so much larger than
Chihuahuas?
IGF1 (encoding insulin-like growth factor 1)
partially explains why
2
Fig. 1. Relationships of skeletal size, SNP
markers, IGF1 haplotype, and serum levels of the
IGF1 protein in PWDs
  • Probability that
  • specific SNPs are
  • associated with
  • size phenotype
  • in Portugese
  • Water dogs (PWD)

B/B
  • B. Frequency
  • of IGF1
  • Genotypes in
  • PWDs

I/I
C. Serum IGF1 phenotypes of B/B, B/I, and
I/I PWDs.
B/I heterozygotes are the dashed line
N. B. Sutter et al., Science 316, 112 -115
(2007)
Published by AAAS
3
Fig. 2. Signatures of recent selection on the
IGF1 locus across 22 small and giant dog breeds
  • Ratio of small breed
  • heterozygotes to large
  • breed heterozygotes.

B. Genetic differentiation between small and
large breeds.
Small breeds
Large breeds
N. B. Sutter et al., Science 316, 112 -115
(2007)
C. SNP heterozygosity along chromosome 15.
Published by AAAS
4
Fig. 4. Association of body size and frequency of
the SNP 5 A allele
Frequency of a specific SNP allele In various
breeds
N. B. Sutter et al., Science 316, 112 -115
(2007)
Published by AAAS
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