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Getting Funded

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Title: Getting Funded


1
Getting Funded
  • When You Have No Preliminary Data
  • Grants-For-Lunch

2
Funding Without Data
  • Also known as
  • Pilot studies
  • Seed money
  • Feasibility studies
  • Phase I feasibility studies
  • Small grants
  • Preliminary studies
  • Exploratory/Developmental Grants
  • Sources
  • NIH R03
  • NIH R21
  • GCRC Pilot grants
  • Other pilot projects and seed grants available at
    UTMB via already funded grants and endowments

3
Common Features of Possible Funding
Opportunities(specifics may vary)
  • Little or no preliminary data required
  • New projects only, no competing continuations
  • New investigators or investigators exploring a
    new area are encouraged
  • Usually provides a limited amount of money for a
    limited amount of time (non-renewable)
  • Support may be for early, conceptual stage of
    development of ideas or for specialized purposes
  • May involve novel, high-risk or previously
    unexplored areas
  • May pave the way for larger studies or grants or
    may be intended to further the career of new
    investigators.

4
R03 NIH Small Grants Program
5
R03 Small Grants
  • Getting started / how to begin
  • http//grants1.nih.gov/grants/funding/r03.htm
  • General Program announcement
  • http//grants.nih.gov/grants/guide/pa-files/PA-03-
    108
  • Not all ICs accept investigator initiated
    (unsolicited) applications
  • Check list of ICs before getting started
  • Applications must include an appropriate Program
    Announcement number and title on line 2 of the
    PHS 398 application

6
R03 Small Grants
  • DEFINITION
  • Supports small research projects that can be
    carried out in a short period of time with
    limited resources. R03 provides support for
    specialized purposes.

7
R03 Small Grants
  • SCOPE
  • Limited funding for short period of time
  • Pilot or feasibility studies
  • Secondary analysis of existing data
  • Small, self-contained research projects
  • Development of research methodology
  • Development of new research technology

8
R03 Small Grants
  • CHARACTERISTICS (unless specified otherwise in a
    program announcement or RFA)
  • Project period up to 2 years
  • Uses modular budget format
  • Direct costs up to 50,000 per year
  • New projects only, no competing continuations
  • No thesis or dissertation research
  • Only one revision of previously reviewed R03
  • Research Plan may not exceed 10 pages
  • Competing continuations not accepted

9
R03 Small Grants
  • CHARACTERISTICS (cont.)
  • Use PHS 398 forms and instructions
  • Accepted at standard application deadlines
  • F A application subject to full UTMB rate
  • Appendix may include only original, glossy photos
    or color images of gels, micrographs, etc.
    provided that a photocopy is also included within
    the page limits of the research plan. No
    publications or other printed material, with the
    exception of preprinted questionnaires or
    surveys, may be included in the appendix.

10
R03 Small Grants
  • REVIEW CRITERIA
  • Discrete, well defined projects
  • Realistically completed in two years
  • Less detail and discussion in research plan than
    R01
  • Less emphasis on methodological details than R01
  • Justification for work provided in lit cites,
    etc.
  • Prelim data not required, particularly in pilot
    and feasibility studies
  • Often designed to support the research of
    scientists in the early stages of establishing
    independent research careers.

11
R03 Small Grants
  • REVIEW CRITERIA (cont.)
  • Reviewers will consider the following
  • Significance does study address important
    problem?
  • Approach is project well developed and
    realistic?
  • Innovation novel concepts used? Existing
    paradigms or clinical practice challenged?
  • Investigator well trained? Work appropriate to
    PI experience level?
  • Environment does it contribute to probability
    of success?
  • NOTE application does not have to be strong in
    all categories to be judged likely to have major
    scientific impact

12
R03 Small Grants
  • REVIEW CRITERIA (cont.)
  • Reviewers will consider the following (cont.)
  • Protection of human subjects
  • Risk to subjects
  • Adequacy of protection against risks
  • Potential benefits of proposed research
  • Importance of knowledge to be gained
  • Inclusion of minorities
  • Inclusion of both sexes / genders
  • Inclusion of children

13
R03 Small Grants
  • REVIEW CRITERIA (cont.)
  • Reviewers will consider the following (cont.)
  • Care and use of vertebrate animals
  • Proposed use of animals in project (species,
    strains, ages, sex, and numbers of animals to be
    used)
  • Justify use of animals
  • Information on veterinary care of animals
  • Procedures to ensure discomfort, distress, pain,
    etc will be limited to that which is unavoidable
  • Describe methods of euthanasia to be used, if any

14
R03 Small Grants
  • NIH ICs that DO accept unsolicited R03s
  • NEI NIA NIAAA
  • NIAID NIBIB NICHD
  • NIDA NIDCR NIEHS
  • NIMH NINDS NINR
  • NLM

15
R03 Small Grants
  • NIH ICs that DO NOT accept unsolicited R03s
  • FIC NCCAM NCI
  • NCMHD NCRR NHGRI
  • NHLBI NIAMS NIDCD
  • NIDDK NIGMS

16
R21NIH Exploratory Developmental Research Grant
Award Program
17
R21 Exploratory Grants
  • Getting started / how to begin
  • http//grants1.nih.gov/grants/funding/r21.htm
  • General Program Announcement
  • http//grants.nih.gov/grants/guide/pa-files/PA-03-
    107
  • Not all ICs accept investigator initiated
    (unsolicited) applications
  • Check ICs before getting started
  • Applications must include an appropriate Program
    Announcement number and title on line 2 of the
    PHS 398 application

18
R21 Exploratory Grants
  • DEFINITION
  • Intended to encourage exploratory and
    developmental research projects by providing
    support for the early and conceptual stages of
    these projects. Studies may involve considerable
    risk but may lead to a breakthrough in a
    particular area. Projects of limited cost or
    scope that use widely accepted approaches and
    methods within well established fields are better
    suited for the R03 small grant mechanism.

19
R21 Exploratory Grants
  • SCOPE
  • Intended for new, exploratory research projects
  • May involve considerable risk but lead to
    breakthrough in a particular area
  • Projects distinct from those supported through
    R01 mechanism
  • Projects to increase knowledge in
    well-established area are not meant for R21
  • Projects of limited cost or scope that use widely
    accepted methods are better suited for R03

20
R21 Exploratory Grants
  • CHARACTERISTICS (unless specified otherwise in a
    program announcement or RFA)
  • Project period up to 2 years
  • Uses modular budget format
  • Combined direct costs for 2 years may not exceed
    275K, no more than 200K in any one year
  • New projects only, no competing continuations
  • Only two revisions of previously reviewed R21
  • Research Plan (a d) may not exceed 15 pages

21
R21 Exploratory Grants
  • CHARACTERISTICS (cont.)
  • Preliminary data not required but may be included
    if available
  • Use PHS 398 forms and instructions
  • F A application use full UTMB rate
  • Use instructions for the appendix detailed in the
    PHS 398 except that no more than 5 manuscripts,
    previously accepted for publication, may be
    included.

22
R21 Exploratory Grants
  • REVIEW CRITERIA
  • Novel, scientific ideas or new model systems
  • Extensive background material not required
  • Reviewers will focus on conceptual framework,
    level of innovation and potential to
    significantly advance knowledge and understanding
  • Less emphasis on methodological details than R01
  • Justification for work provided in lit cites,
    etc.
  • Preliminary data not required

23
R21 Exploratory Grants
  • REVIEW CRITERIA (cont.)
  • Reviewers will consider the following
  • Significance does study address important
    problem?
  • Approach is project well developed and
    realistic?
  • Innovation novel concepts used? Existing
    paradigms or clinical practice challenged?
  • Investigator well trained? Work appropriate to
    PI experience level?
  • Environment does it contribute to probability
    of success?

24
R21 Exploratory Grants
  • REVIEW CRITERIA (cont.)
  • Reviewers will consider the following (cont.)
  • Protection of human subjects
  • Risk to subjects
  • Adequacy of protection against risks
  • Potential benefits of proposed research
  • Importance of knowledge to be gained
  • Inclusion of minorities
  • Inclusion of both sexes / genders
  • Inclusion of children

25
R21 Exploratory Grants
  • REVIEW CRITERIA (cont.)
  • Reviewers will consider the following (cont.)
  • Care and use of vertebrate animals
  • Proposed use of animals in project (species,
    strains, ages, sex, and numbers of animals to be
    used)
  • Justify use of animals
  • Information on veterinary care of animals
  • Procedures to ensure discomfort, distress, pain,
    etc will be limited to that which is unavoidable
  • Describe methods of euthanasia to be used, if any

26
R21 Exploratory Grants
  • NIH ICs that DO accept unsolicited R21s
  • NCCAM NCRR NEI
  • NIA NIAAA NIAID
  • NIBIB NICHD NIDA
  • NIDCD NIDCR NIEHS
  • NIMH NINDS NLM

27
R21 Exploratory Grants
  • NIH ICs that DO NOT accept unsolicited R21s
  • FIC NCI NCMHD
  • NHGRI NHLBI NIAMS
  • NIDDK NIGMS NINR

28
Sample funded R21 research proposal
  • Mind-Body Interactions and Health
    Exploratory/Developmental Research Program
    Psychoneuroimmunology, Stress, and Healthy Aging
    n Hispanics. R21 application submitted by Dr.
    Victor Sierpina FY2004 http//cam.utmb.edu/resea
    rch.asp
  • Dr. Victor Sierpina, Department of Family
    Medicine, has granted permission for potential
    applicants at UTMB to view this document as an
    example of a R21 Developmental award application
    that received funding . This proposal was
    submitted in response to a solicitation
    RFA-OB-03-005.

29
Comparison of R03/R21
  • R03
  • Uses widely accepted approaches and methods
  • Funding for up to 2 years
  • Modular budget format
  • Direct costs up to 50,000/yr
  • New projects only, no competing continuations
  • Only one revision
  • Research Plan may not exceed 10 pages
  • R21
  • Exploratory and novel approaches and methods
  • Funding for up to 2 years
  • Modular budget format
  • Combined direct costs for 2 years may not exceed
    275K, no more than 200K in any one year
  • New projects only, no competing continuations
  • Only two revisions
  • Research Plan (a d) may not exceed 15 pages

30
Comparison of R03/R21(cont.)
  • R03
  • No thesis or dissertation research
  • Use PHS 398 forms and standard application
    deadlines
  • Use full UTMB FA rate
  • Appendix may include original, color/glossy
    images, provided a photocopy is also included
    within the page limits of the research plan. No
    publications or other printed material, with the
    exception of preprinted questionnaires or surveys.
  • R21
  • Preliminary data not required
  • Use PHS 398 forms
  • Use full UTMB FA rate
  • Use PHS398 instructions for Appendix, except no
    more than 5 manuscripts, previously accepted for
    publication, may be included.

31
Pilot Funding available on the UTMB
campushttp//research.utmb.edu/funding/opportuni
ties.shtm
32
UTMB Pilot Funding
  • GCRC Clinical Research Feasibility Funds
    (CReFF)The CReFF Program focuses on support for
    pilot studies. The purpose is to support
    promising investigator-initiated human studies on
    the GCRC that might not otherwise be possible
    without this support, and to encourage
    investigators to propose pilot studies to be
    conducted on the GCRC. Support will be given for
    a defined GCRC protocol for up to one year.
    Priority will be given to junior investigators
    with appropriate mentors who propose pilot
    observations that are likely to lead to
    extramural grant support. For more information,
    contact the General Clinical Research Center at
    gcrc_at_utmb.edu

33
UTMB Pilot Funding (cont.)
  • UTMB Center on Aging External Funding for Aging
    Research and Education/training ProgramsEmphasis
    on funding pilot projects The Sealy Center on
    Aging has been able to award pilot funding based
    on funds received from the Sealy endowment, the
    Claude D. Pepper Older Americans grant (funds 3
    to 4 pilots per year), and the Center for
    Populations Health and Health Disparities grant
    (funds 4 pilots per year). From 1997 - 2003 the
    Sealy Center on Aging has awarded funds to
    support 46 pilot projects. Several pilot projects
    have produced R01 grants.

34
UTMB Pilot Funding (cont.)
  • Center for Population Health and Health
    Disparities (CPHHD) Pilot Research GrantsFunding
    of up to 50,000 per year for up to two years is
    available to support pilot projects involving
    health disparities.  A priority for this funding
    is to stimulate laboratory-based and
    interdisciplinary investigations exploring
    mechanisms for disparities in health by
    ethnicity, socioeconomic status, etc.  A major
    component of the UTMB CPHHD is a population based
    longitudinal study of stress and health in
    approximately 2,000 Mexican American adults in
    Galveston County.  This program was offered for
    the first time in the fall of 2003 with funding
    originating with NIH. The last round was held in
    October, 2004.For further information contact 
    Kyriakos Markides, kmarkide_at_utmb.edu or James
    S.Goodwin, jsgoodwi_at_utmb.edu

35
UTMB Pilot Funding (cont.)
  • Center for Addiction Research Fostering
    Advances in Addiction Science Pilot Grant Program
    Funds research in the mechanisms/processes
    underlying drug abuse and addiction, including
    (but not limited to) targeted genomic/proteomic
    studies to discover molecular mechanisms of
    addiction, translational research in addiction
    and systems biology approaches to integrative
    models of addiction. Up to three pilot grants
    (30,000 each) for one year, with possibility for
    two years. Faculty at the Assistant Professor
    level and above are eligible to apply. The
    program is designed to promote interdisciplinary
    research collaborations among UTMB faculty that
    will ultimately result in external funding. The
    last due date was November 29, 2004.For further
    information Theresa Tarrant, tltarran_at_utmb.edu

36
UTMB Pilot Funding (cont.)
  • CIRWH Seed Grant ProgramThe Center for
    Interdisciplinary Research on Womens Health seed
    grants are intended to support promising basic,
    clinical, or translational research relevant to
    the general area of womens health and likely to
    lead to significant external grant funding.The
    next round of these competitive grants of 12,500
    will be announced in the spring. The grants will
    be open to UTMB faculty at the assistant
    professor level and above who are conducting
    research in women's health. The center also
    encourages applications from more senior UTMB
    investigators gathering pilot data for new
    multidisciplinary projects in women's health.
    The last round was held in September, 2004.For
    further information contact Joanna Bremer,
    jobremer_at_utmb.edu

37
UTMB Pilot Funding (cont.)
  • NIEHS Center in Environmental Toxicology at UTMB
    Pilot ProjectsLimited funds are available to
    support Pilot Project studies in the
    Environmental Health Sciences. Research
    proposals should have a strong emphasis on the
    Centers interests in the environmentally-related
    problems of oxidative stress and signaling, DNA
    repair and mutagenesis, biotransformation, asthma
    pathogenesis, and environmentally based community
    outreach and education programs. Special priority
    will be placed on applications which emphasize
    collaborative efforts. It is anticipated that
    four pilot projects will be funded for up to
    17,500 for one year. The next deadline is
    February 15, 2005.Contact RayKay Santa,
    rksanta_at_utmb.edu or Jonathan B. Ward, Jr.
    ,jward_at_utmb.edu.

38
UTMB Pilot Funding (cont.)
  • UTMB Mind-Body Research Scholars Program
    Provides seed grants to help foster
    interdisciplinary mind-body research through
    mentoring, training in research tools, techniques
    and writing skills. Seed grants in the amount of
    5000-7500 for the period of 1 year.
    Approximately 4-6 researchers will be awarded
    annually. UTMB tenure and non-tenure track
    faculty at the assistant professor level or above
    are eligible to apply. Preference will be given
    to junior faculty and investigators entering
    mind-body research as a new field. Applications
    are also encouraged from UTMB investigators
    gathering pilot data for new multidisciplinary
    projects in the area of stress and coping
    behaviors addressing the needs of Hispanic
    patients and the elderly. The deadline for the
    first round (FY2005) is in February 14.
    Contact Pam Bass or Dr. Victor Sierpina,
    vssierpi_at_utmb.edu.

39
UTMB Pilot Funding (cont.)
  • John Sealy Memorial Endowment Fund for Biomedical
    Research Research Development GrantsThe purpose
    of the Research Development Grant program is to
    stimulate the development of new research
    initiatives through the support of pilot projects
    that have a very high probability of attracting
    new biomedical research grants to UTMB.
    Investigators at the rank of Assistant Professor
    or above are eligible to apply. Grants may be
    awarded for up to 35,000 per year for up to two
    years.  Applications accepted January, April and
    September.  The next deadline (for 2005 only) is
    February 1, Contact Helen Cook,
    hcook_at_utmb.edu

40
Resources for identifying funding when you have
no preliminary data
  • Research Services Website http//research.utmb.e
    du/
  • UTMB Yellow Sheet http//research.utmb.edu/resear
    ch/yellowsheet/ysonline.htm
  • SPIN funding database and SMARTS GENIUS funding
    alerts http//rdhs.utmb.edu/
  • NIH Guide http//grants1.nih.gov/grants/guide/inde
    x.html
  • NIH Website for new investigators
    http//grants.nih.gov/grants/new_investigators/ind
    ex.htm
  • Contact
  • Linda Crumpler, Reference LibrarianResearch
    Services Funding LibraryRebecca Sealy EastRoom
    4.400DRoute 0156Phone 266-9431Email
    lcrumple_at_utmb.edu
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