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Workshop 3: Funding Opportunities

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... Research. Overview of CIPRA. Mission/Goals. 3 Grant Mechanisms ... A grant program that supports comprehensive research and development efforts at ... – PowerPoint PPT presentation

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Title: Workshop 3: Funding Opportunities


1
  • Workshop 3 Funding Opportunities
  • Conducting HIV Treatment Research
  • In Resource Poor Countries
  • Workshops and Training Sessions
  • October 20-21, 2003
  • Baltimore, Maryland
  • Joan Romaine, MPH
  • Health Specialist
  • Division of AIDS, Office of International
    Research
  • National Institute of Allergy and Infectious
    Diseases
  • National Institutes of Health
  • United States Department of Health Human
    Services

2
Overview
  • Need for International Research
  • Overview of CIPRA
  • Mission/Goals
  • 3 Grant Mechanisms
  • Application Process and Timelines
  • Other NIH Funding
  • NIAID
  • Grants, Contracts, Training
  • Resource Guide for the Development of AIDS
    Therapies
  • PA-03-062
  • FIC
  • AITRP
  • ICOHRTA 1
  • IRSDA
  • GRIP
  • Related Training
  • NIH
  • Grants and Funding Opportunities Web site
  • NIH Guide Listserv

3
Need for International Research on AIDS
  • Rapidly expanding pandemic in the developing
    world
  • Devastating effect on populations, economic
    development and national security
  • Critical need for more effective and sustainable
    strategies to prevent and treat HIV/AIDS
  • Need for local scientists to address their
    countrys research needs
  • Global collaboration is essential

4
(No Transcript)
5

6
Comprehensive International Program of Research
on AIDS

What is CIPRA? A grant program that supports
comprehensive research and development efforts at
organizations located in eligible nations to
develop practical, affordable, and acceptable
methods to prevent and treat HIV/AIDS in adults
and children.
7
CIPRA Approach
  • Research and infrastructure
  • Enhance developing country capabilities and
    capacity to conduct research relevant to their
    populations
  • Provide long-term support for epidemiologic,
    laboratory and clinical studies to lay the
    foundation for research on practical and
    affordable methods to prevent and treat HIV/AIDS

8
Examples of CIPRA Research
  • Clinical, and basic laboratory research
  • Epidemiological studies of HIV transmission
  • Therapeutic research
  • Vaccine and prevention research

9
CIPRA Who Can Apply
  • Research or clinical care organizations in
    eligible countries
  • Application must come from host country
    applicants only
  • Eligible countries
  • GNP per capita lt US 5,000 (World Bank)
  • As of Dec 1, 2003 the most current Gross
    National Income (GNI) per capita data from the
    World Bank will be used for new applications. So
    GNI per capita lt US 5,000 (World Bank)

10
CIPRA Grants and Timeline
  • Planning Organizational
  • 50,000/year for up to 2 years
  • non-renewable
  • Exploratory Developmental Research
  • 500,000/year for up to 5 years
  • non-renewable
  • Multi-Project Research Program
  • Program-determined budget, funding for 5 years
    with potential for competitive renewal

R03
U01
U19
11
CIPRA Grants and Timelines
3 Grant Mechanisms
Descriptions
Multi-Project Research Program-determined
budget, funding for up to 5 years, with
potential for competitive renewal
U19
Exploratory/Developmental Research
500,000/year, up to 5 years, non-renewable
U01
R03
Planning and Organizational 50,000/year, up
to 2 years, non-renewable
Start here
CIPRA Support
12
Current CIPRA Awards
13
Current CIPRAs
R03 Planning and Organizational Grants
  • Argentina (Buenos Aires) Argentinean National
    Ref Ctr AID
  • Brazil (Caxias do Sul)
  • University of Caxias do Sul
  • Brazil (Porto Alegre)
  • Centro de Estudos Luis Guedes
  • Brazil (Rio de Janeiro)
  • FIOTEC
  • Cambodia (Phnom Penh)
  • Cambodian Health Committee
  • Congo (Brazzaville)
  • National Lab of Public Health
  • Dominican Republic (Puerto Plata)
  • Cenro de Promoc Solidard Human
  • Egypt (Cairo)
  • Egyptian Ministry of Health and Population
  • Georgia (Tbilisi)
  • IDACIRC
  • India (New Delhi)
  • Indian Council of Medical Research
  • Mexico (Cuernavaca Morelos) National Institute
    of Public Health
  • Mozambique (Beira)
  • Universidade Catolica de Mocambique
  • Peru (Lima)
  • Assoc Civil Impacta Salud y Education
  • Russian Federation (St. Petersburg) Saint
    Petersburg Pavlov Med Univ
  • Tanzania (Moshi)
  • Kilimanjaro Christian Medical Center
  • Thailand (Cihang Mai)
  • Chiang Mai University
  • Trinidad (Port of Spain)
  • Med Res Fdn of Trinidad Tobago
  • Vietnam (Ho Chi Minh City)
  • Ho Chi Minh City AIDS Committee
  • Zambia (Lusaka)
  • Center for Infectious Disease
  • Zambia (Ndola)
  • Tropical Diseases Research Center
  • Zimbabwe (Harare)

14
Current CIPRAs
U01 Exploratory/Developmental Research Grants
  • Senegal (Dakar) Univ of Cheikh Anta Diop
  • U19 Multi-Project Research Grants
  • China (Beijing) National Center AIDS
    Prevention and Control
  • South Africa (Durban) CAPRISA
  • South Africa (Johannesburg) Univ of
    Witwatersrand

15
R03 Planning and Organizational Grant
16
R03 Planning and Organizational Grant
  • Types of activities
  • Organize a research group
  • Plan a research program
  • Establish necessary collaborations
  • Build and train administrative organization
  • Develop skills and resources necessary to prepare
    a competitive application (U01 or U19)
  • 50,000 (direct cost) per year, plus 8 indirect
    cost
  • For up to 2 years
  • Not renewable

17
What Can A R03 Grant Support?
  • Salaries of senior leadership/scientists, and
    support staff
  • Travel
  • Training Program
  • Collaborations
  • limited to less than or equal to 20 (outside
    host country)
  • with established PIs

18
CIPRA Grants (U01/U19)
  • NIH Cooperative Agreements
  • CIPRA Investigator responsibility
  • research agenda
  • project/study performance and analysis
  • scientific publications
  • NIH CIPRA Program Partner
  • assist with scientific decisions/directions
  • facilitate research with information and
    available resources
  • provide appropriate level of coordination and
    monitoring

19
U01 Exploratory and Developmental Research Grant
20
U01 Exploratory / Developmental Research Grant
  • Build and further develop from the R03 planning
    phase
  • Types of Activities
  • Expand and develop research group
  • Plan and develop new research areas
  • Further develop administrative organization
    (training and staff development)
  • Expand infrastructure and collaborations
  • Prepare for a comprehensive multi-project effort
    (U19)
  • Implement a focused research project
  • 500,000 cost per year for up to 5 years

21
What Can a U01 Grant Support?
  • Costs necessary to carry out a focused research
    project
  • Develop Facilities (including equipment)
  • Supplies
  • Project Staff (including recruitment and
    training, etc.)
  • Professional scientific, clinical
  • Technical
  • Administrative

  • Continued

22
What Can a U01 Grant Support?
  • Implementation of pilot studies to prepare for a
    multi-project grant
  • Development of collaborations with other research
    institutions in the host country or region

23
U19 Multi-Project Research Grant
24
U19 Multi-Project Research Grant
  • Comprehensive coordinated program
  • includes treatment and prevention activities
  • Multiple research projects
  • two or more required
  • Cores shared resources or facilities that
    support 2 or more projects
  • administration, lab, etc.

25
Principal Investigator (PI) of Multi-Project
CIPRAs
  • Provides overall direction
  • Scientific leadership
  • Administration and management leadership
  • Communication coordination
  • among projects and cores
  • with other research organizations NIH
  • Responsibilities require significant time
    commitment of the PI

26
Activities that could be included in a CIPRA Core
  • May be in place or need development or
    enhancement
  • Administrative management
  • Clinical trials management oversight
  • Communications systems
  • Data management
  • Statistical analysis
  • Training
  • Laboratory support

27
CIPRA Multi-Project Cooperative Agreement (U19)
(Examples of Cores and Projects)
  • Cores
  • Administrative Support
  • Good Clinical Practice (GCP) and budget oversight
  • Ethical review
  • Central Laboratory
  • HIV and OI diagnosis
  • Immunology
  • Virology
  • Animal testing
  • Data Management/Statistics
  • Regulatory/Pharmacy
  • Community Affairs and Education
  • Research Projects
  • Epidemiology of HIV transmission
  • Clinical/Laboratory research in preparation for
    HIV vaccine or prevention trials
  • Therapeutic research on effective management of
    HIV/AIDS
  • Preclinical HIV vaccine development
  • Feasibility study for a microbicide trial

28
CIPRA Training Plan
  • Aim to build staff capability and expertise at
    every level to carry out CIPRA research
  • Includes advanced training and mentoring for
    development of research leaders
  • Training plans may be coordinated with Fogarty
    International Center AITRP

29
Examples of Infrastructure Development
  • Build administrative capacity for
  • Oversight, coordination, organizing ethical
    review personnel, communications, training, Good
    Clinical Practice (GCP), fiscal management
  • Research support
  • Technical equipment and supplies, data
    management, literature accessibility, informatics
  • Laboratory
  • Acquire special equipment and personnel
  • Staff Training and Development
  • Alterations and Renovations

30
Summary of CIPRA
  • Comprehensive
  • prevention and treatment components
  • Multi-disciplinary research approaches
  • integrated projects and aims
  • International
  • requires host country leadership
  • addresses host country research needs
  • develops sustainable infrastructure
  • establishes national and/or international
    collaborations

31
  • CIPRA Application Process

32
Step 1 CIPRA Web site
  • Read information on the CIPRA Web site
    http//www.niaid.nih.gov/cipra

33
  • Note that the CIPRA Program has 3 grant
    mechanisms for funding
  • R03 Planning and Organizational Grants
  • U01 Exploratory/Developmental Research
  • Grants
  • U19 Multi-Project Research Grants

34
Step 2 Letter of Interest (LOI)
  • Eligibility
  • Country has GNP per capita of less than or equal
    to 5,000 USD
  • If eligible, prepare Letter of Interest (LOI)
  • Briefly identify your proposed research
  • Include a plan for the development of CIPRA
    activities/capabilities
  • See LOI Instructions and Policy on Web site for
    more information
  • Email LOI to cipra_at_niaid.nih.gov
  • If email is not available you should mail your
    letter to
  • Dr. Rodney HoffDivision of AIDSNational
    Institute of Allergy and Infectious
    DiseasesNational Institutes of HealthRoom 4157,
    MSC 7628Bethesda, MD 20892-7628USA
  • Or, you may fax it to (301) 493-0590

35
Step 3 CIPRA Point Person
  • CIPRA Reference Number
  • CIPRA Point Person
  • CIPRA Team

36
Step 4 Review of LOI and Outcomes
  • Review of LOI by CIPRA Point Person
  • Presentation of LOI to CIPRA Team
  • CIPRA Team Recommendation
  • Expected Outcomes
  • an invitation to submit a CIPRA application is
    given (Letter of Eligibility)
  • a request to revise and resubmit the LOI
    addressing specific questions about the LOI or
    improving it in some areas before an LOE is given
    and a CIPRA application is prepared
  • a determination that the current LOI is
    non-responsive (without major revisions) and you
    are not eligible to submit a CIPRA application.
    A new LOI may be submitted if it incorporates
    major changes.

37
Step 5 Letter of Eligibility (LOE)
  • For those eligible, you will receive via fax and
    mail, with email confirmation, a Letter of
    Eligibility signed by Dr. Rodney Hoff.
  • Letter of Eligibility must be included in all
    application packages.

38
Step 6 CIPRA Review Cycle
  • 2 application receipt dates
  • 1 March and 1 November
  • Average timeline from application to award,
    approximately 15 months

Please be aware that problems at any step would
result in delays further down in the schedule.
39
Step 7 Post-award
  • Scientific Reporting Requirements
  • Maintain contact with NIAID Program
  • Yearly Progress Reports
  • Fiscal Responsibility

40
CIPRA Contact Information
  • CIPRA
  • E-mail CIPRA Team at cipra_at_niaid.nih.gov
  • Write to
  • Dr. Rodney Hoff
  • Division of AIDS
  • National Institutes of Allergy and Infectious
    Diseases
  • National Institutes of Health
  • Room 4149, MSC-7628
  • Bethesda, MD 20892-7628
  • USA
  • For courier or express delivery use zip code
    20817

41
Additional NIH Funding Opportunities
  • What are they
  • and
  • Where can I find out about them?

42
NIAID / DAIDS
http//www.niaid.nih.gov/ncn/
43
NIAID / DAIDS
  • DAIDS Resource Guide for the Development of AIDS
  • Therapies

http//www.niaid.nih.gov/daids/pdatguide/overview.
htm
44
NIAID cont.
  • PA-03-062
  • Small Research (R03) Grants for International
    Research in Infectious Diseases at NIAID
    International Sites
  • http//grants.nih.gov/grants/guide/pa-files/PA-03-
    062.html

45
Fogarty International Center
http//www.fic.nih.gov
  • AIDS International Training and Research Program
    (AITRP) supports research training for
    epidemiology, biomedical, behavioral, social
    sciences
  • International Clinical, Operational and Health
    services Research Training Award (ICOHRTA 1)
    supports training for clinical, operational and
    health services research. Requires a parent
    grant from co-sponsoring NIH Institute
  • International Research Scientist Development
    Award (IRSDA) career development award for
    junior US investigators for international
    research
  • Global Health Research Initiative Program for New
    Foreign Investigators (GRIP) research program
    for foreign scientists trained at NIH
    (intramural) or received long term training
    through FIC research training program
  • Related Training Programs bioethics, medical
    informatics, MCH, etc.

46
NIH
  • Grants Funding Opportunities
  • http//grants1.nih.gov/grants/index.cfm
  • Subscribe to NIH Guide listserv for weekly
    listings of TOC


http//grants1.nih.gov/grants/guide/listserv.ht
m
47
Questions Answers
  • Joan Romaine, MPH
  • Phone 301.451.2708
  • Email JRomaine_at_niaid.nih.gov
  • Thank you!
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