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Research Training Directors Meeting

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Title: Research Training Directors Meeting


1
Research Training Directors Meeting
Timothy P. Condon, Ph.D. Deputy Director National
Institute on Drug Abuse
2
NIDA Research
3
NIH
NEI
NHLBI
NHGRI
NCI
NIA
OD
NIAMS
NIBIB
NICHD
NIAID
NIDCD
NIAAA
NIEHS
NIGMS
NIDDK
NIMH
NIDCR
NIDA
NLM
CIT
CSR
NINR
FIC
NINDS
NCCAM
NCMHD
NCRR
4
NIDA
National Institute on Drug Abuse
Office of the Director
Nora D. Volkow, MD
Director
Director, AIDS Research
Special Populations Office
Timothy P. Condon, Ph.D.
Deputy Director
Laura S. Rosenthal
Associate Director for Management
Office of Extramural Affairs
Office of Planning Resource Management
Office of Science Policy Communications
Center for the Clinical Trials Network
Teresa Levitin, PhD
Laura Rosenthal
Timothy Condon, PhD
Betty Tai, PhD
Division of Epidemiology, Services Prevention
Research
Division of Pharmacotherapies Medical
Consequences of Drug Abuse
Division of Basic Neurosciences Behavior
Research
Intramural Research Program
Division of Clinical Neuroscience Behavioral
Research
David Shurtleff, PhD
Frank Vocci, PhD
Wilson Compton, MD, MPE
Barry Hoffer, MD, PhD
Joseph Frascella, PhD
5
to lead the nation in bringing the power of
science to bear on drug abuse and addiction

6
Addiction
Medical
NEUROTOXICITY OBESITY AIDS CANCERMENTAL ILLNESS
DRUGS
Economic
Social
HEALTH CARE COSTS PRODUCTIVITY
LOSS ACCIDENTS
HOMELESSNESS CRIME VIOLENCE
7
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8
NIDA BUDGET
(Thousands)
2007PB
2007House
2007Senate
2005Actual
2006Approp.
693,282
699,956
695,563 299,266 994,829
994,829
1,000,342
NonAIDS
313,137
300,073
AIDS
1,006,419
1,000,029
TOTAL
Increase Over Prior Year
1.2
-0.6
-0.5
-0.5
---
9
it is ever more important for us to shine the
light on the right spot for emerging drug issues
As NIDAs budget tightens,
10
.and to build partnerships ..and to seek
out innovative ways to accomplish
our goals
11
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12
Challenge of Rising U.S. Health
Expenditures Biomedical Research Must Deliver
20
National Health Expenditures as a Percent of GDP
Actual Projected
18
16
14
Percent of U.S. GDP
12
10
8
2012
2009
2006
2003
2000
1997
1994
1991
1988
1985
1982
1980
2015
Source http//new.cms.hhs.gov/NationalHealthExpen
dData/downloads/nheprojections2004-2014.pdf
13
NIH Congressional Appropriations
30
28.6
28.6
28.6
28.0
27.1
25
?
23.3
20
20.5
17.8
15
Billions of Dollars
15.6
13.7
10
5
0
FY
FY
FY
FY
FY
FY
FY
FY
FY
FY
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
DOUBLING
14
The Budget Cycling PhenomenonWhat Funds are
Available in any One Year?
From current year to previous year
Budget Increase
Uncommitted Funds
From ending grants started 4-5 years ago
Continuing grants
Committed Funds
NIH Appropriations
15
FY 2006 Presidents Budget RequestTotal NIH
Budget Authority28.740 Billion
Training 3 764 Million
Research Project Grants 53 15.494 Billion
16
NIDA Budget for FY 2006
FY 2006 990 M
17
As Many Applicants in Past 2 Years as During
Previous 5 Years!
5334
5208

26583 - 21249
31791 - 26583
(2003) (1999)
(2005) (2003)
Period of doubling
18
NIH Competing Funds Remain Relatively Constant
Amount of NIH Extramural Awards (Excluding RD
Contracts)
25,000
Competing
Noncompeting
20,000
15,000
Dollars Awarded (Millions)
10,000
5,000
0
1998
1999
2000
2001
2002
2003
2004
2005
Fiscal Year
19
Comparing the of Grant Applications Funded (or
Success Rate) with the Number of New
Applications
35
60,000
32
32
30
32
31
50,000
31
30
49,656
25
46,501
25
40,000
43,069
Projected
40,862
22
20
Number of Applications
20
Success Rate of Grants Funded
30,000
19
34,710
15
28,368
27,798
30,069
26,407
20,000
24,154
10
10,000
5
0
0
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
Success Rates
Applications
20
The Question on Everyones MindWhat are MY
chances of being funded?
21
Payline Is Not Funding Cut-off Line
-
100
Percent R01s Funded
0
0
10
20
30
40
Percentile Score
22
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23
Age
Year
24
First Major Independent Research Support Occurs
at an Ever-Later Age
Average Age of Initial Type 1 R01/R23/R29 Award
for Different Degrees Held

45
44
44
43
42
42
M.D.-Ph.D.
41
M.D.
Average age
40
40
39
Ph.D.
38
38
37
37
36
35
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
Fiscal Year
For more information, see http//grants.nih.gov/g
rants/20040712_New_Investigator_Talk.ppt
25
New Investigators on R01 Awards as a Percentage
of Competing Investigators
26
New Investigators Program
NIH is Committed to Providing Pathways to
Research Independence For New Investigators
Pathway to Independence Award
NRSA Individual and Institutional Training Awards
Career Development Awards
Research Project Grant Program
NIH Institute and Center Practices
Resources for New Investigators
NIH Pathway to Independence Award Program
  • Announced January 27, 2006
  • Opportunity for promising postdoctoral
    scientists to receive both
  • mentored and independent research support
    from the same award
  • Responsive to NAS 2005 Report Bridges to
    Independence
  • Beginning in Fall 2006 NIH plans to issue 150
    to 200 awards/year
  • for the next 5 years

27
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28
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29
NIH Roadmap Mission
  • Expedite basic research discoveries and speed
    the translation of those discoveries into
    clinical practice

30
NIH Roadmap for Medical Research
  • Developed to
  • Increase synergy across NIH
  • Respond to concerns about the perceived
    balkanization of NIH (Congress, IOM report)
  • Developed with wide extramural input
  • Beyond the scope of a single Institute or Center
    and benefits all
  • Emerging areas of science
  • High risk/high impact research
  • Enabling science infrastructure

31
Three Themes of the Roadmap
New Pathways to Discovery
Re-engineering the Clinical Research Enterprise
Research Teams of the Future
32
New Pathways to Discovery
  • Molecular Libraries and Imaging Probes
  • Building Blocks, Biological Pathways and Networks
  • Structural Biology
  • Bioinformatics and Computational Biology
  • Nanomedicine

33
Research Teams of the Future
  • High-Risk Research (Pioneer Awards)
  • Interdisciplinary Research
  • Public-private Partnerships

34
Re-engineering the Clinical Research Enterprise
  • Translational Research Initiatives (CTSA)
  • Harmonization of Clinical Research Policy
  • Clinical Research Networks and NECTAR
  • Dynamic Assessment of Patient-Reported Disease
    Outcomes
  • Clinical Research Training

35
NIH Roadmap Strategy
36
NIH Roadmap for Medical Research
  • Not a single initiative but over 345 individual
    awards in FY05
  • 40 basic
  • 40 translational
  • 20 high risk
  • Creates Incubator Space to accelerate critical
    research efforts that address major cross-cutting
    NIH priorities
  • This Incubator Space is now a permanent part of
    NIH Office of Portfolio analysis and Strategic
    Initiatives (OPASI)

Roadmap Funding
600
1.2 - 1.7 NIH Budget
500
400
Dollars in Millions
300
200
100
0
FY04
FY05
FY06
FY07
FY08
FY09
37
Common Fund for Shared Needs
  • Common Fund will fund initiatives that are in
    areas of interest to multiple ICs
  • Current Roadmap funds will serve as the baseline
    for the Common Fund 1.1 of the total NIH budget
    in FY 2006, growing to 1.7 in FY 2008
  • Future growth of the Common Fund
  • No growth above the FY 2008 percent until the
    annual NIH budget increase exceeds Biomedical
    Research and Development Price Index (BRDPI)
  • Rate of growth will be determined annually by NIH
    Director and IC Directors
  • Common Fund will increase up to 5 of the total
    NIH budget

38
Roadmap Funding(dollars in millions)
(Totals may not add due to rounding)
39
NIDA and the NIH Roadmap
  • Co-lead on an Interdisciplinary Research
    Initiative
  • Development of innovative methodology in social
    and behavioral sciences research
  • Involved in the development of clinical trials
    networks
  • Supports the Molecular Libraries and Imaging
    Roadmap Initiative

40
NIH Roadmap
NIDA FY2004 Roadmap Awards (NIDA FY04
Contribution 3.4M)              
                                                
      Year 1            Year 2  7 Grants
Awarded to NIDA Researchers    2,065,403    
3,139,055 15 Grants Related to NIDAs
Research       2,490,070     2,547,116 Total
Amount of 1st 2nd Year Awards     
4,555,473    5,686,171
NIDA FY2005 Roadmap Awards (NIDA FY05
Contribution 6.36M)  
                                       
             Year 1    8 Grants Awarded to
NIDA Researchers      1,516,243     16
Grants Related to NIDAs Research        
14,591,510   Total Amount of First Year Awards
           16,152,753
41
Road Map II Strategic Initiative Inclusion
Criteria
  • The overarching goal of all Roadmap initiatives
    is to accelerate the
  • discovery and translation of scientific knowledge
    into public health
  • benefits. Roadmap is conceived of as a five to
    ten year incubator space
  • for NIH initiatives that meet all of the
    following criteria
  • Is the proposed initiative truly transforming
    could it dramatically affect how biomedical
    and/or behavioral research is conducted over the
    next decade?
  • Will the outcomes from the proposed initiatives
    synergistically promote and advance the
    individual missions of the Institutes and Centers
    to benefit health?
  • Does the proposed initiative require
    participation from NIH as a whole and/or does it
    address an area (s) of science that does not
    clearly fall within the mission of any one IC or
    OD program office?
  • Is the proposed initiative something that no
    other entity is likely or able to do, and is
    there a public health benefit to having the
    results of the research in the public domain?

42
Schedule for Roadmap II
  • July 3 consultation meetings with
    extramural scientists
  • August Submission of initiative concepts
    from IC
  • September 2 additional consultation meetings
  • Pilot test responsiveness
    determination
  • process on nominations to
    date
  • October Release RFI for comments idea
    nominations
  • from the broad
    public/research community
  • November Mini-Retreat to review and prioritize
    idea
  • nominations

43
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44
The Neurosciences Blueprint Effort Will Provide
A Platform to
  • Develop tools
  • Integrate resources
  • Optimize public and private partnerships
  • Facilitate translational research

Knowledge Technology
Neuroinformatics Standardization
45
Neuroscience Information Framework
NIH Goal To develop a comprehensive, dynamic
inventory of Web-accessible neuroscience informat
ion resources that span multiple levels of
biological function
Laboratory of Neuroinformatics Weill Medical
College of Cornell University
SOCIETY FOR NEUROSCIENCE
PI -- Daniel Gardner
  • Five Groups at Caltech, Cornell, UCSD, George
    Mason,
  • and Yale have partnered with the SfN and with
    volunteer
  • collaborators at nine additional sites to
    develop
  • The Framework
  • Terminology/Ontology for neuroscience
  • A content-based query tool

Phase I began September 30, 2005
46
NIH Neuroscience Blueprint
FY 2005 (Tap 0.15)
FY 2006 (Tap 0.30)
Project Team Lead IC GENSAT
expansion NINDS Neurobiology of Disease
Training Supplements NIMH Neuroscience
Inventory NIDA
Project Team Lead IC Core Grants
NINDS Neuromouse NIMH Training NIDA
  • Neuroimaging Training
  • Computational Neuroscience
  • Neurobiology of Disease

47
RFAs
Neuroscience Blueprint Interdisciplinary Center
Core Grants (RFA-NS-06-003) -- Issued September
29, 2005 Application Receipt Date January 19,
2006 Development of Recombinase-Expressing
(Driver) Mouse Lines for Studying the Nervous
System (U01) (RFA-MH-06-007) Issued November 18,
2005 Application Receipt Date January 19,
2006 Training in Translational Research in
Neurobiology of Disease (T32) (RFA-DA-06-008) --
Issued November 9, 2005 Application Receipt
Date February 22, 2006 Training in
Computational Neuroscience From Biology to
Model and Back Again (T90) (RFA-DA-06-101) Issued
December 16, 2005 Application Receipt Date
March 13, 2006 Training in Neuroimaging
Integrating First Principles and Applications
(T90) (RFA-DA-06-011) Issued December 23, 2005
Application Receipt Date March 13, 2006
48
Visit Our Website _at_
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