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Title: CIHRs 13 Institutes


1
(No Transcript)
2
CIHRs 13 Institutes
3
Four Research Pillars of CIHR
  • Biomedical
  • Clinical
  • Health services and health systems
  • Health of populations, societal and cultural
    dimensions of health, and environmental
    influences on health

4
CIHR Budget 2005-2006
5
Canadian Institutes of Health Research
Institute of Neurosciences, Mental Health and
Addiction
6
CIHR-INMHA a Canadian Experiment
  • Virtual institute aimed to promoting
  • interdisciplinary approaches to the study of
    neuroscience, mental health, addictions and the
    sensory systems
  • integration of neuroscience (including vision,
    hearing, communication, pain, etc.), mental
    health and addiction research
  • Unique model in the world
  • Quirion (2002) A Canadian experiment INMHA. How
    to link up the brain via a virtual institute.
    TINS 25 268-270

7
Institute Advisory Board 2004-2005
  • Dr. Anthony Phillips (Chair)
  • Dr. Kathryn Bennett
  • Dr. Serge Brochu
  • Dr. Yves de Koninck
  • Ms. Judy Hills
  • Dr. Judy Illes
  • Mrs. Mary Jardine
  • Dr. Alain Lesage (vice-chair)
  • Dr. Ravi Menon
  • Dr. Freda Miller
  • Dr. Marlene Reimer
  • Dr. Patrice Roy
  • Dr. Michael Salter
  • Dr. Eric Single
  • Dr. Martin Steinbach
  • Dr. Jane Stewart
  • Dr. Donald Weaver
  • Dr. Douglas Zochodne
  • University of British Columbia, Vancouver BC
  • McMaster University, Hamilton ON
  • Université de Montréal, Montreal (Quebec)
  • Université Laval, Quebec City (Québec)
  • Public Representative, Toronto ON
  • Stanford University, Palo Alto CA
  • Public Representative, Toronte ON
  • Université de Montréal, Montréal QC
  • University of Western Ontario, London ON
  • University of Toronto, Toronto ON
  • University of Manitoba, Winnipeg MB
  • Pfizer Canada, Montréal QC
  • University of Toronto, Toronto ON
  • University of Toronto, Toronto ON
  • York University, Toronto ON
  • Concordia University, Montréal QC
  • Dalhousie University, Halifax NS
  • University of Calgary, Calgary AB

8
INMHA IAB Focus Groups
  • Ethics and Law
  • Government Affairs and Networking
  • Industry and biotechnology
  • International Affairs
  • Performance Evaluation and Budget
  • Training and Education
  • Voluntary Sector and Professional Organizations
  • Clinical Research

9
INMHA Vision
  • The Institute of Neurosciences, Mental Health
    and Addiction believes that innovative, ethically
    responsible research will lead to better health
    for all Canadians.

10
INMHA Mission
  • The mission of the INMHA is
  • to foster excellence in innovative, ethically
    responsible research that increases our knowledge
    of the functioning and disorders of the brain and
    the mind, the spinal cord, the sensory and motor
    systems, and mental health, mental illness and
    all forms of addictions.
  • To foster cutting-edge research that incorporate
    the four pillars of CIHR biomedical, clinical,
    health services and health systems, and
    population health
  • to translate this new knowledge into improved
    health outcomes and quality of life for all
    Canadians.

11
INMHA Values
  • INMHA
  • Commits to the support of excellence, scientific
    integrity and ethics in research that meets the
    highest international standards
  • Cultivates an understanding of the diversity of
    the disciplines covered by the INMHA mandate in
    order to expand beyond traditional approaches to
    research
  • Affirms the importance of research and knowledge
    translation as means of making a difference in
    the lives of people who are experiencing or who
    are at risk for the disorders and illnesses of
    concern to the INMHA

12
INMHA Values
  • INMHA
  • Respects ethical, transparent and effective
    governance and management processes that
    establish the INMHAs credibility and strengthen
    its organizational capacity
  • Acknowledges its accountability to the Governing
    Council of the CIHR, the Government of Canada and
    Canadians for the accomplishment of its mission.

13
INMHA Strategic Goals
  • To accomplish its mission, the INMHA will
  • Promote and support excellence in peer-reviewed,
    internationally recognized and ethically
    responsible research in the domains of the
    Institute, including co-occurrence with other
    health problems and co-morbidity
  • Encourage trans-disciplinary research in order to
    facilitate knowledge transfer aimed at developing
    and improving health care treatments and
    services
  • Ensure the training and support of the next
    generation of Canadian scientists in all aspects
    of neurosciences, mental health, and addiction by
    promoting and sustaining the development of
    trans-disciplinary programs of research and
    training.

14
INMHA Strategic Goals
  • To accomplish its mission, the INMHA will
  • Work with non governmental and volunteer health
    organizations, municipal governments and other
    interested stakeholders to reduce the
    discrimination and prejudices associated with
    neurological and sensory disorders, mental
    illnesses and addictions
  • Promote the visibility and mandate of the INMHA
    and its contribution through effective
    communication with all sectors of civil society

15
INMHA Strategic Goals
  • To accomplish its mission, the INMHA will
  • Work with the Government of Canada, provincial
    and territorial governments, members of the
    scientific community, non governmental and
    volunteer health organizations, foundations and
    all Canadians to ensure that sufficient human and
    financial resources, consistent with the burden
    of disease of the disorders covered by the INMHA,
    are made available to the Institute in order to
    enable it to achieve its goals.
  • Interact with all stakeholders to identify
    research priorities, establish partnerships and
    undertake collaborative activities.

16
Approaches Used to DevelopINMHA First Strategic
Plan
  • Visits to universities and research centres
    across the country (gt30)
  • Two NGO meetings
  • http//www.cihr-irsc.gc.ca/e/8586.html
  • International visits
  • NIH, WHO, PAHO, etc.
  • Prioritization by IAB and Scientific Director
  • 2001-2005 Strategic Plan

17
Outcomes of consultations
18
INMHA Strategic Priority One
  • To foster and develop a capacity for innovation
    in research in neurosciences, mental health and
    addiction
  • Training
  • Strategic Initiatives
  • Early Life Events and First episodes in brain
    disorders
  • Co-occurrence of brain disorders with other
    health problems and co-morbidity
  • Regenerative Medicine and Nanonmedicine
  • Nicotine addiction and tobacco abuse
  • Emerging areas and unique opportunities
  • Research in bioethics

19
INMHA Strategic Priority Two
  • To pursue and sustain collaborative partnership
  • The INMHA will
  • Collaborate with the Strategic Partnerships and
    Alliances and the Industry Program Branches of
    CIHR in identifying and developing potential
    partnerships
  • Develop sustainable partnerships with other
    Institutes and with governmental organizations at
    the national and international levels as well as
    with NGOs and VHOs
  • Collaborate and partner with NGOs and VHOs in
    effort aimed at advancing
  • Advocacy, information dissemination, knowledge
    translation, training, leverage funding,
    surveillance, community support

20
INMHA Strategic Priority Three
  • To promote linkage and exchange through
    structured efferts aimed at knowledge translation
  • The INMHA has defined the following strategies
  • Collaborate with CIHR in developing a framework
    for contributing to public policies and programs
    that will help create an environment conducive to
    the development of the CIHR and its institutes
  • Engage in structured, individual activities that
    promote linkage and exchange
  • Develop a comprehensive stakeholder knowledge
    translation strategy

21
INMHA Strategic Priority Four
  • To insure INMHAs presence on the international
    stage
  • The INMHA will help Canadian scientists by
    promoting and developing joint research and
    training initiatives with institutes in other
    countries. This strategy will enable the INMHA
    to
  • Develop and pursue collaborations international
    research projects and funding
  • Promote and establish trainee exchange programs
    at the international level.

22
INMHA Strategic Priority Five
  • To establish an effective organizational and
    operational structure
  • The INMHAs organizational structure and
    operational processes must support the efforts
    and endeavours of the Institute, and ensure its
    accountability to CIHR and its stakeholders.
    Three components of the strategy have been
    identified
  • Implement an effective governance, accountability
    and management structure and process
  • Develop and sustain structured communication
    efforts aimed at informing and gaining an
    understanding of the health and research issues
    related to INMHAs domains
  • Develop a framework for gathering, maintaining
    and accessing relevant and reliable health and
    research information in the fields of interest to
    the INMHA.

23
INMHA Institute Support Grant
  • 1 million/year since 2001
  • Staff salaries
  • Conference, symposia and workshops
  • Annual Meeting
  • Annual reports and brochures
  • Web site (www.thebrain.mcgill.ca)
  • IAB expenditures
  • Travel
  • Office rental
  • Supplies
  • International Activities
  • Partnership Development

24
INMHA Strategic Initiative Budget
25
INMHA Strategic Initiative Budget 2004-2005
26
Some INMHA initiatives (2002-2005)
  • Brain Star Award
  • Strategic Training Initiative in Health Research
  • Bridging Operating Grants
  • Priority announcement
  • New Emerging Team Program
  • Strategic Initiatives
  • Inter-institute partnerships
  • International Collaborations
  • Workshops and scientific meetings

27
INMHA Strategic Priority One
  • Training Grants and
  • Salary Support

28
Brain Star Program
  • To recognize the excellence of research done by
    trainees in all fields covered by our Institute
  • 1,000 per award
  • Awarded every 2 weeks
  • Based on a research article recently published as
    first author in a high impact journal
  • Cross-pillar is a plus
  • Brain Star of the year since 2003
  • For more details
  • www.cihr-irsc.gc.ca/e/8585.html

29
Recent Brain Star Awardees
  • McMaster (Dalhousie) Hippocampal volume in early
    onset of depression
  • (2004) BMC Medicine 2 2
  • Cotrell (Queens) Prokiceticin 2 modulates the
    excitability of subfornical organ neurons
    (2004) J Neurosci. 242375
  • Thompson (Toronto) Variant of the Orexin2/hcrt2
    receptor gene identified in patients with
    excessive daytime sleepiness and patients with
    Tourettes syndrom comorbidity (2004) AM. J.
    Med. Genet. 129 B(1)69-75
  • Nicholls (UBC) Assessing risk of violence among
    male and female civil psychiatric patients
    The HCR-20, PCLSV, and VSC (2004) Behav. Sci
    Law 22 127-158
  • Kogan (McGill) Differential impact of the FMR1
    gene on visual processing in fragile X
    syndrome
  • (2004) Brain 127 591-601

30
Brain Star of the year
  • 2003 Michelle Aarts and Yitao Liu
  • Aarts M., Liu Y., Bessoh S., Arundine M., Gurd
    J., Wang Y.T., Salter M. (2002) Brain damage by
    perturbing NMDA receptor PSD-95 protein
    interactions Science 298846-850.
  • 2004 Jeffrey Coull
  • Coull J., Boudreau D., Bachand K. Prescott S.A.,
    Nault F., De Koninck P.Y. (2003) Transynaptic
    shift in anion gradient in spinal lamina I
    neurons as a mechanism of neuropathic pain.
    Nature 424938-942

31
Strategic Training Initiativein Health Research
  • First competition 2001
  • CIHR central and Institutes supported
  • 51 teams funded
  • 8 of them related to INMHA
  • 300K per year for 6 years
  • Cross-pillars and multi-centres favoured

32
Strategic Training Initiativein Health Research
  • First Competition 2001-2002
  • Teams related to INMHA
  • Cameron (Waterloo) Tobacco Research
  • De Koninck (Laval) Neurophysics Setting new
    frontiers in neurosciences with material
    sciences and photonics
  • Fenster (UWO) Vascular and cerebrovascular
    transdisciplinary training program
  • Houry (Toronto) Protein folding. Principles and
    diseases
  • McGrath (Dalhousie) Pain in child health
  • Reithmeier (Toronto) Structural biology of
    membrane proteins linked to disease
  • Salter (Toronto) Pain research. From molecules to
    community
  • Vincent (UBC) Neurobiology and behaviour

33
Strategic Training Initiativein Health Research
  • Second competition 2002
  • Funded by each Institute
  • INMHA received 15 LOI
  • With internal and external (FRSQ, NAAR) partners
    INMHA is associated to 10 successful applications
  • Funding for six years started in April 2003

34
Strategic Training Initiative in Health Research
Second Competition 2001-2002
  • Antel (McGill) Integrated Training Program in
    basic and clinical aspects of
    neuroinflammation
  • Chaudhuri (McGill) McGill integrative
    neurobehavioral training program focus on
    regenerative medicine and early life events
  • Fombonne (McGill) Training program in autism
    research
  • Goldner (UBC) Building capacity in mental health
    and addiction services and policy research
  • Holden (Queens) Transdisciplinary
    inter-institute training program in autism
    spectrum disorders
  • Kirmayer (McGill) Culture and mental health
    services
  • Meaney (McGill) Genes, environment and health
    training program
  • Mishara (UQAM) Formation interdisciplinaire en
    recherche sur le suicide et sa prévention
  • Selby (Toronto) Tobacco use in special
    populations
  • Wilson (York) CIHR strategic training program in
    vision research

35
STIHR WORKSHOP Nov. 28-29, 2005
  • A STIHR Workshop will be held on Nov. 28-29, 2005
    in Montreal, for all training program grants
    related to INMHA

36
INMHA Salary Awards - Spring and Fall 2002
  • Doctoral Research Award (11)
  • Post-doctoral Fellowship (8)
  • Senior Research Fellowship (1)
  • New Investigators (2)
  • Clinician Scientists (2)
  • Senior Investigator (1)

37
INMHA Doctoral Research Award
  • Alain (Montréal) Les processus C-REM induits par
    stimulations vibratoires pendant le sommeil
    NREM
  • Arudine (Toronto) Cellular and molecular
    mechanisms of secondary neurotrauma
  • Beauchamps Étude des résultats des traitements
    psycho-
  • (McGill) sociaux auprès des jeunes présentant
    un premier épisode de schizophrénie
  • Bédard (Toronto) Application of virtual reality
    technology in assessing cognitive function in
    children with ADHD
  • Brouillette (McGill) Action neuroprotectrice de
    lIGF-1 Rôles des akt kinases et régulation
    génomique
  • Caraiscos (Toronto) Enhancement glycine receptor
    function by insulin receptor-mediated pathways

38
INMHA Doctoral Research Award
  • Ghasemlou Characterization of trkA and p75
    neurotrophin (Queens)
    receptor function in sympatetic and sensory
    axonal growth
  • Lefebvre (Dalhousie) Use of event-related brain
    potentials and standardized
    neuropsychological stimuli in the
    understanding and assessment of working
    memory abilities in patient following brain
    injury
  • Ohayon (Toronto) Recurrent neural network models
    of kindling
  • Sharif (McGill) Differential contribution of the
    nervous system to inflammation and joint
    destruction in an animal model of
    monoarthritis
  • Thibeault (Laval) Rôle de la réponse immune dans
    le système nerveux central

39
INMHA Fellowships
  • Henriques Kinesthetic guidance of limb
    movements (Minneapolis) Kinesthetic spatial
    perception and its role in action
  • Moller (Toronto) Screening for neurocognitive
    impairment and road safety in sleep disorders
    using the virtualized environment of a
    computerized driving simulator
  • Powell (Dalhousie) Effects of fetal neurons and
    stem cell derived neurons on pre- and
    post-synaptic gene expression in striatum
    and substantia nigra
  • Rose (Valencia) Effect of acute brain liver
    failure on cerebral function Brain
    metabolism and signal transduction pathways
  • Van der Werf Cortical oscillations in the
    healthy and disordered (McGill) brain Studies
    with transcranial stimulation

40
INMHA Senior Research Fellowships
  • Marotta (York) Hemispatial neglect A
    multidisciplinary investigation of the
    effect on visual perception and visually
    guided action

41
INMHA New Investigators
  • Joober (McGill) Genetics of schizophrenia From
    animal models to human studies
  • Yan (Calgary) Neural mechanisms of
    learning-induced auditory plasticity Role of
    cortical acetylcholine and corticofugal
    modulation

42
INMHA Clinician scientists
  • Daskalakis A study of cortical inhibition and
    (Toronto) plasticity in schizophrenia using
    transcranial magnetic stimulation
  • Dupré (McGill) Clinical and genetic study of a
    new form of recessive cerebellar ataxia
    frequently encountered in the Beauce
    region (Québec) and the surrounding area

43
INMHA Senior Investigator
  • Szatmari (McMaster) Understanding developmental
    trajectories in autism

44
INMHA Strategic Priority One
  • Grant Funding and
  • Strategic Initiatives

45
INMHA First Two Initiatives
  • IHRT
  • Karpati et al. (McGill University)
  • Gene Therapy for Neurological Disorders
  • (ICR, IHDCYH, IMHA, Neuroscience Canada, Muscular
    Dystrophy of Canada)
  • CAHR (IAPH/INMHA Special Project)
  • Kirmayer et al. (McGill University)
  • National Network for Aboriginal Mental Health
    Research

46
Research in emerging areas
  • Institute-specific initiatives
  • New Emerging Team (NET)
  • 3 to 6 independent investigators
  • senior and junior investigators
  • Collaborative multidisciplinary research
  • Up to 300,000 per year for five years

47
Research in emerging areas
  • NET Research Themes for 2001-2002
  • Discrimination and stigma
  • Understanding the placebo effect
  • Neurodevelopment and early life events
  • Computational neurosciences and artificial
    intelligence

48
Neurodevelopment and early life events
  • Brien (Queens) Fetal alcohol syndrome,
    oxidative stress and innovative therapies
  • Honer (UBC) Interactions of development, early
    life experience, and genetic predisposition
    in schizophrenia
  • Paus (McGill) Long-term consequences prenatal
    exposure to maternal cigarette smoking on
    brain structure, function and mental health
    in adolescence Role of genes and
    environment in brain development
  • Robaey (Montréal) Inattention, impulsiveness and
    restlessness in childhood Heritability,
    genetics, neuropsychology and
    psychophysiology (KIDNET)

49
Computational neurosciences and artificial
intelligence
  • Kalaska Learning task decomposition in
  • (U de Montréal) large-scale biological and
    artificial neural networks
  • McIntosh Development of integrative
  • (U of Toronto) computational neuroscience
    program to understand human mental
    function

50
Research in emerging areas
  • NET Research Themes for 2002-2003
  • Discrimination and stigma (Re-issued)
  • Understanding the placebo effect (Re-issued)
  • Post-traumatic stress syndrome
  • Comorbidity and co-occurrence
  • Regenerative Medicine - Neurosciences

51
Post traumatic stress disorder
  • Asmundon Understanding Risks Factors,
  • (U of Regina) Co-morbidity, and Global
    Health Issues in PTSD
  • Coupland  STRESS  Stress, Trauma
  • (U of Alberta) and Recovery Early Stage
    Studies

52
Understanding the Placebo Effect
  • Lavigne Comprendre leffet placebo à
  • (U de Montréal) partir détudes expérimentales
    et cliniques sur le sommeil et la douleur
    impliquant des états de vigilance altérés

53
Regenerative Medicine _ Neuroscience
  • Weaver
  • (UWO)
  • In partnership with
  • Ontario Neurotrauma Foundation
  • Spinal Cord Injury Discovery and development of
    rescue and repair strategies.

54
Research in emerging areas
  • NET Research Themes for 2003-2004
  • Neuroethics
  • Downie (Dalhousie University)
  • Neuroimaging ethics From theory to practice
  • Suicide Prevention targeted to Aboriginal People
    (with IAPH)
  • Andersson (CIET, Ottawa) Aboriginal Community
    Youth Resilience Network (ACYRN) Community-led
    research and resources to prevent youth suicide
  • Turecki (McGill U.) Understanding and acting on
    Aboriginal suicide A new multidisciplinary
    research team

55
Research in emerging areas
  • NET Research Themes for Dec. 2004
  • Neuroethics (re-issued)
  • Suicide prevention targeted to Aboriginal People
    (re-issued)
  • Mental Health in the Work Place (with IPPH)
  • For June 2005
  • Mental Health in the Work Place

56
Research in emerging areas
  • Analysis of the Canadian Health Survey on Mental
    Health and Well-Being (Health Services and
    Policy Research, Gender and Health as well as
    Statistics Canada, Ontario Problem Gambling
    Research Centre and Northern Health Research
    Initiative)
  • Caron (McGill U) Le soutien social, la santé
    mentale et le bien-être des populations pauvres
    au Canada
  • Cole (McGill U) Health services use by Canadian
    seniors with major depression
  • Cox (U of Manitoba) Two population-based mental
    health studies using the CCHS (cycle 1.2) social
    phobia and problem gambling
  • DArcy (U of Saskatchewan) A mental health
    divide? Rural-urban and intra-rural differences
    in mental health services

57
Research in emerging areas
  • Analysis of the Canadian Health Survey on Mental
    Health and Well-Being (2)
  • Dewa (U of Toronto) Psychiatric disorders,
    chronic physical conditions, workplace stress and
    disability in the Canadian working population
  • Fournier (U de Montréal) Troubles anxieux chez
    les jeunes de 15 à 24
  • ans évolution, déterminants et recours aux
    services
  • Lesage (U de Montréal) Utilization of services
    for mental health reasons-
  • cross provincial differences in rates and
    determinants
  • Newman and Thompson (U of Alberta) Prevalence and
    correlates of pathological gambling
  • Patten et al. (U of Calgary) Descriptive
    epidemiology of major depression in the Canadian
    population
  • Roman (U of Toronto) Gender issues in depression
    and anxiety for Canadians less than 65 years of
    age

58
Research in emerging areas
  • Analysis of the Canadian Health Survey on Mental
    Health and Well-Being (3)
  • Rush (U of Toronto) Concurrent substance use and
    mental disorders in Canada prevalence and impact
    on service utilization
  • Sareen (U of Manitoba) Correlates of mental
    health services utilization and emotional
    well-being Analysis of the CCHS survey cycle 1.2
  • Stewart et al. (U of Toronto) The relation
    between work-related factors and mental health in
    Canada men and women
  • Streiner and Cairney (U of Toronto) Psychiatric
    disorders, associated risk factors and mental
    health services use among adults aged 55 and
    older in Canada
  • Tempier (McGill U) General practice and mental
    health care a Canadian-Australian comparative
    study

59
Research in emerging areas
  • Analysis of the Canadian Health Survey on Mental
    Health and Well-Being (4)
  • Waraich and Streiner (UBC) Validation of
    administrative cases of major depressive disorder
    using CCHS 1.2 data
  • Zumbo (UBC) Bias in self-reported health services
    utilization in the CCHS on mental health and
    well-being Influences of age, gender, personal
    characteristics and patterns of care

60
Research in emerging areas
  • In partnership with IHSPR
  • Vingilis (UWO) Marrying knowledge generation with
    knowledge diffusion and utilization  The
    consortium for applied research and evaluation in
    mental health
  • In partnership with IHSPR
  • Kisely (Dalhousie U) Measuring quality in mental
    health services across Nova Scotia evaluation of
    a demonstration site
  • Dewa (U Toronto-CAMH) Examining the effectiveness
    of a collaborative care model for individuals
    with severe mental illness
  • In partnership with IGH
  • Violence, Gender and Health across the lifespan
  • Pepler (York U) Preventing violence in the lives
    of girls and women A focus on relationships
  • McMillan (McMaster U) Health impacts of violence
    across the lifespan. A multidisciplinary approach.

61
Research in emerging areas
  • In partnership with the Fogarty Centre of the NIH
  • Stigma and Global Health
  • C. Benoit (University of Victoria)
  • Joint RFA to be re-issued in 2006

62
INMHA Bridging Funds
  • One-year operating grants for highly-rated
    proposals
  • Priority Announcements
  • March 2002 Competition (13 projects funded)
  • September 2002 Competition (3 projects funded)
  • March 2003 Competition (1 project funded)
  • September 2003 (3 projects funded)
  • March 2004 (3 projects funded)
  • September 2004 (5 projects funded)
  • March 2005 (6 projects funded)
  • Majority successful in obtaining CIHR/NIH
    operating grants in subsequent competition (70)

63
INMHA Bridging Funds March 2002
  • Bartha (UWO) Monitoring metabolism and tissue
    magnetic susceptibility during acute focal
    cerebral ischemia
  • Brown (UWO) In vivo and in vitro studies of
    EphA3 and EphA4 signaling
  • Carlen (Toronto) Synaptic mitochondria
    Physiology and pathophysiology
  • Cuello (McGill) Studies on the plasticity of CNS
    cholinergic neurons
  • Fehlings (Toronto) Apoptosis after spinal cord
    injury The role of Fas, p75NTR, and NF-kappaB
  • Franklin (McGill) Sex steroids and depression as
    modulators of pain sensitivity (with IMHA)
  • Gianoulakis (McGill) Alcoholism, central opioid
    activity and stress responses as a function
    of family history and gender

64
INMHA Bridging Funds March 2002
  • Mishra (McMaster U) Role of catecholamine
    regulated proteins (CRPs) in schizophrenia
  • OCraven Understanding the neural mechanisms of
    visual
  • (U of Toronto) cognition fMRI studies of human
    extrastriate cortex
  • Peters (UWO) Procedures for image-guided
    neurosurgery in the deep brain
  • Prat (U de Montréal) Functional analysis of the
    metalloendopeptidase NRDc
  • Rossi (UBC) A model for regulated delivery of
    neuropeptides to the CNS through microglia
    mediated gene therapy
  • Sullivan (Montréal) Cerebral laterality,
    prefrontal cortex and stress

65
INMHA Bridging Funds September 2002
  • Gratton, Meaney (McGill) Early experience and the
    development of the corticolimbic dopamine
    system
  • Niles (McMaster) Neurotrophine induction and
    neuroprotection by melatotin in
    Parkinsons disease
  • Vaucher (Montreal) Modulation cholinergique du
    cortex visuel du rat

66
INMHA Bridging Fund March 2003
  • Antel (McGill) Cellular immune injury of human
    oligodendrocytes

67
INMHA Bridging Fund September 2003
  • Kerouac (Memorial U.) Regulation of orexin
    (hypocretin) neurons by monoaminergic and
    cholinergic systems
  • Létourneau Support for women who experienced
    symptoms
  • (U of Alberta) of postpartum depression
  • Zhang (U of Toronto) Cellular mechanisms of
    hippocampal sharp wave and associated fast
    oscillations

68
INMHA Bridging Funds March 2004
  • Sarret (U de Sherbrooke) Régulation des
    récepteurs de la neurotensine Implication
    dans le contrôle de la douleur
  • Karim (McGill U) Towards an understanding of
    reconsolidation
  • Joanisse (UWO) The brain bases of speech
    perception Imaging studies of normal adults
    and developmentally impaired children

69
INMHA Bridging Funds September 2004
  • Fouad (U of Alberta) Combining axonal growth
    promoting treatments with rehabilitative
    training
  • Magoski (Queenss U) The role of calcium channel
    in controlling neuronal excitability
  • Morshead (U of Toronto) Examining the function
    and regulation of adult mammalian neural stem
    cells
  • Soja (UBC) State-dependent control of spinal
    interneurons
  • Zadra (U of Montreal) Precipitating factors and
    psycho- physiological correlates of adult
    somnambulism

70
Bridging Funds March 2005
  • Allen (U. of Alberta) In-vivo magnetic resonance
    spectroscopic quantification of brain
    metabolites
  • Chahine (U. of Laval) Modulation of nav1.7 and
    nav1.8 two peripheral nerve Na channels by
    local anesthetics and auxiliary
    beta-subunits
  • Mishra (McMaster U) Role of synapsin II in
    schizophrenia and its regulation by typical
    and atypical antipsychotic drugs
  • Poulter (U. Carleton) GABA-A receptor plasticity
    in response to experimental epilepsy
  • Ross (U. of Alberta) In vivo exploration of brain
    connectivity in temporal lobe epilepsy
  • Duquette (U. of Montreal) Further exploration of
    the mechanisms underlying motor dysfunction
    in antipsychotic drug-treated monkeys

71
INMHA Four Major Strategic Initiatives
  • Nicotine Addiction and Tobacco Abuse
  • Co-occurrence of brain disorders with other
    health problems and comorbidity
  • Early Life Events and First Episodes of Brain
    Disorders
  • Regenerative Medicine and Nanomedicine

72
1st Major Strategic Initiative
  • Nicotine addiction and tobacco abuse
  • National Summit, Ottawa, April 2002
  • Report on CTCRI Web site (www.ctcri.ca)
  • RFA Advancing the science to reduce tobacco
    abuse and nicotine addiction June 2003
  • Partners
  • CIHR INMHA, ICR, IAPH, ICRH, IGH, IHDCYH
  • National Cancer Institute, Canadian Cancer
    Society, Heart and Stroke Foundation, Health
    Canada, Canadian Lung Association, Association
    pulmonaire du Québec
  • Funding in 2004

73
1st Major Strategic Initiative
  • Nicotine addiction and tobacco abuse
  • Two teams supported for 5 years by INMHA and many
    other partners (June 2004)
  • P. Clarke (McGill U.)
  • Nicotine addiction Behavioral and brain
    mechanisms from rodents to humans
  • P.W. McDonald (U. of Waterloo)
  • A Pan-canadian Resource Network for Tobacco
    Control Research, Policy and Practice

74
1st Major Strategic Initiative
  • Nicotine addiction and tobacco abuse
  • Re-issued in December 2004
  • RFA on Research in Addiction with CTCRI, CCSA,
    OPGRC and other partners
  • http//www.cihr-irsc.gc.ca/e/25700.html
  • Tobacco Abuse and Nicotine Addiction (re-issued)
    and Community based research grants with CTCRI
  • www.ctcri.ca
  • Funding starts in 2006

75
2nd Major Strategic Initiative
  • Co-occurrence of brain disorders with other
    health problems
  • NET Program May 2002
  • Consultation Workshop on September 22-23, 2005,
    in Ottawa to plan development of a RFA with
    partners in June 2006

76
3rd Major Strategic Initiative
  • Early Life Events and
  • First episodes in Brain Disorders
  • In partnership with IHDCYH
  • Steering Committee, Halifax, October 2002
  • Workshop, Montréal, February 9-10, 2004
  • Report on the Web, Spring 2004
  • RFA in mid-December 2004
  • www.cihr-irsc.gc.ca/e/25650.html
  • Funding for team grants to be announced in 2006

77
4th Major Strategic Initiative
  • Regenerative Medicine and Nanomedicine
  • (1 of 4 CIHR Large Strategic Initiatives)
  • stem cells, nanomedicine, gene therapy, tissue
    engineering, rehabilitation
  • Brain and spinal cord repair
  • IHRT on Gene therapy (Karpati, McGill U.)
  • NET on Spinal Cord Injury (Weaver, UWO)
  • Vision and hearing losses
  • Partners
  • CIHR INMHA, IG, ICR, ICRH, III, IMHA
  • Canadian Genetic Diseases Network, Canadian
    Stroke Network, Juvenile Diabetes Research
    Foundation International, Heart and Stroke
    Foundation, NSERC, NRC, Neuroscience Canada,
    Stem Cell Network, Canada Space Agency, etc
  • Nanomedicine Workshop, Feb. 2003
  • Annual Meeting - Nanomedicine, Feb. 2004 and
    March 2005
  • RFA in June 2003, re-issued in June 2004 and June
    2005
  • For details www.regenerativemedicine.ca

78
4th Major Strategic Initiative
  • Regenerative Medicine and Nanomedicine
  • 1st competition
  • New Discoveries High Risk Grant (with IG)
  • Jefferies (UBC) Delivery of therapeutics proteins
    across the blood-brain barrier
  • Invention, Tools and Devices
  • Kirby (Dalhousie) Rear anti-tip devices for
    manual wheelchairs Effect of new vs
    conventional design on performance, user
    satisfaction and social participation
  • Scott (Queens) KINARM - A robotic tool for
    objective assessment of upper limb motor
    function
  • De Koninck Novel microprobes for combined
    optical and
  • (U. Laval) electrical recording in vivo

79
4th Major Strategic Initiative
  • Regenerative Medicine and Nanomedicine
  • 5 year Team Grants 1st competitition
  • W. Chan (U of Toronto) Quantum dot-based
    biomolecular imaging
  • M. Fehlings (U of Toronto) Regenerative medicine
    strategies for spinal cord injury repair
    Integration of stem cell biology, nanotechnology,
    bioengineering approaches and neurosurgical
    application
  • A. Daar (U of Toronto) Regenerative Medicine
    Ethical, Environmental, Economic,  Legal and
    Social Issues Network
  • S. Rivest (Université Laval) Engineered bone
    marrow stem cells (BMSCs) for treatment of CNS
    injuries and diseases
  • I. Brunette (U de Montréal) Femtosecond Laser
    Assisted Corneal Posterior Lamellar
    Transplantation with Endothelial Enhancement
    Technological Developement and Socioeconomic
    Impact
  • W. Stanford (U of Toronto) Stem cell fate
    analysis and manipulation
  • J. Galipeau (McGill U) Cardiovascular and
    respiratory stem cell plasticity CARE project.
  • Y. de Koninck (Université Laval) Nanotools for
    neuropharmacology

80
4th Major Strategic Initiative
  • Regenerative Medicine and Nanomedicine
    Innovative Approaches in Health Research
  • RFA re-issued in June 2004 and June 2005
  • Team Grants
  • New Discoveries High Risks Seed Grants
  • Funding starts in 2006 and 2007
  • www.cihr-irsc.gc.ca/e/22842.html

81
INMHA Strategic Priorities Two and Four
  • Partnership and
  • International Visibility

82
Inter-Institute Partnerships
  • Include most if not all CIHR Institutes, for
    example
  • Analysis of the Canadian Community Health Survey
    on Mental Health and Well-Being (IHSPR, IGH and
    Statistics Canada, Ontario Problem Gambling
    Research Centre and Northern Health Research
    Initiative)
  • Gene Therapy (ICR, IHDCYH, IMHA and NeuroScience
    Canada and Muscular Dystrophy Association of
    Canada)
  • Training Program in Aboriginal Mental Health
    (IAPH)
  • Alcoholism and Gender (Gender and Health)
  • ICE (IHSPR)
  • Outreach Initiative for NGOs (IGH)
  • Strategic Training Initiative in Health Research
    (most institutes)
  • One-year Bridging Funds
  • Large Strategic Initiatives

83
National Partnerships
  • EJLB-CIHR Michael Smith Chair in Neurosciences
    and Mental Health with the Royal Society of
    Canada and EJLB Foundation
  • (Min Zhuo, University of Toronto)
  • Barbara Turnbull Award with Barbara Turnbull
    Foundation for Spinal Cord Research and
    NeuroScience Canada
  • (50,000 added to the top grant in spinal cord
    research)
  • David Kaplan, U of Toronto, 2002
  • Mohammad Sawan, École polytechnique, Montréal,
    2003
  • David Bennett, U of Alberta, 2004
  • Canadian Tobacco Control Research Initiative /NCI
  • RFA Advancing the Science to Reduce Tobacco
    Abuse and Nicotine Addiction

84
National Partnerships
  • Ontario Neurotrauma Foundation
  • NET Program on Regenerative Medicine /
    Neurosciences (Weaver, UWO)
  • Regenerative Medicine and Nanomedicine
  • Fonds de la recherche en santé du Québec
  • Joint Funding for 6 Strategic Training Initiative
    Grants
  • McGill University and UQAM
  • Canadian Medical Association
  • Physician Mental Health and Well-Being Grants
  • Brewster (U of Toronto) Development of a guide
    for common indicators fo Canadian Physician
    Health Programs
  • Maranda (U Laval) The psychodynamics of the work
    of physicians A well-being and mental health
    issues

85
National Partnerships
  • Neurobiology of Psychiatric Disorders and
    Addictions Grants Programs (to be repeated in
    2005)
  • Canadian Psychiatric Research Foundation and
    Astra Zeneca (with CIHR/RxD)
  • Boksa (McGill University)
  • Maternal infection during pregnancy as a risk
    factor for schizophrenia
  • Li (University of Saskatchewan)
  • A neuroprotective mechanism of atypical
    antipsychotics in haloperidol-induced
    neurotoxicity
  • Phillips (University of British Columbia)
  • Biochemical and behavioural characterization of
    an animal model of schizophrenia induced by
    sensitization to amphetamine
  • Van Tol (University of Toronto)
  • Identification of psychosis susceptibility genes
    using C. elegans

86
National Partnerships
  • Astra Zeneca Canada / Royal University Hospital
    Foundation --U. of Saskatchewan / Schizophrenia
    Society of Saskatchewan
  • Chair on Schizophrenia
  • Ontario Problem Gambling Research Centre
  • Eric Single Studentship
  • Analysis of Canadian Community Health Survey on
    Mental Health and Well-Being
  • Workshop on Problem Gambling
  • RFA on Research in Addiction
  • Canadian Centre for Substance Abuse (CCSA)
  • Alcohol and Illicit Drugs Forum
  • Joint RFA on Research in Addictions
  • Eric Single Studentship
  • NSERC, NRC, CSA
  • Regenerative Medicine and Nanomedicine

87
National Partnerships
  • Health Canada
  • Nicotine Addiction and Tobacco Abuse
  • Regenerative Medicine and Nanomedicine
  • Workshops
  • Suicide Research in Canada
  • Alcohol and Illicits Drugs
  • Statistics Canada
  • Analysis of the Canadian Community Health Survey
    on Mental Health and Well-Being

88
National Partnerships
  • Schizophrenia Society of Canada
  • Co-sponsor of New Investigator Award
  • NeuroScience Canada
  • Barbara Turnbull Award for Spinal Cord Research
  • National Brain Repair Program
  • F. Miller (U of Toronto) Novel Appproach to CNS
    white matter repais
  • M. Salter (U of Toronto) Transforming research
    on chronic pain in Canada
  • Y.T. Wang (UBC) Novel therapeutic strategies to
    repair brain abnormalities in psychiatric
    disorders

89
National Partnerships
  • Vascular Health and Dementia Research Grant
    Program (to be repeated in 2005)
  • IA, CIHR-RxD, Heart and Stroke Foundation of
    Canada, Alzheimer Society of Canada and Pfizer
    Canada
  • G. Boulay (Université de Sherbrooke)
  • Intracellular calcium signaling and vascular
    dementia
  • P. Carlen (University of Toronto)
  • Alzheimer's Disease, Aging and the Ischemic
    Synapse
  • D. Corbett (Memorial University of Newfoundland)
  • Exercise, aging and cognitive impairment
  • W. Zhang (National Research Council of Canada)
  • Neurovascular Unit in Alzheimer's Disease and
    Cerebral Amyloid Angiopathy

90
National Partnerships
  • Heart and Stroke Foundation of Canada
  • RFA on Nicotine Addiction and Tobacco Abuse
  • RFA on Regenerative Medicine and Nanomedicine
  • Stem Cell and Stroke Networks of Excellence
  • Miller (U of Toronto)
  • Weiss (U of Calgary)

91
International Partnerships
  • Japan-Canada Post-doctoral Fellow Exchange
    Program
  • 3 Japanese post-docs
  • Program terminated and replaced by
  • JSPS-CIHR Joint Health Research Program
  • New joint funding program with Japan Society for
    the Promotion of Science
  • INMHA lead CIHR Institute
  • First joint competition September 2003
  • One joint grant funded
  • Michael Salter, U. of Toronto
  • Re-issued in September 2004
  • 6 grants funded

92
International Collaborations
  • NIH Institutes and NIH Fogarty International
    Center
  • (see NIH Web Site at www.fic.nih.gov) to be
    repeated in 2005
  • Stigma and Global Health
  • joint RFA in 2002
  • C. Benoit (University of Victoria)
  • Joint RFA to be re-issued in 2005
  • Tobacco
  • Brain Disorders in the Developing World
  • joint RFA in 2002 to be repeated in 2005
  • Workshop on Manual Therapies in Bethesda,
    Maryland, on June 9-10, 2005 with IMHA
  • RFA, Identifiying Autism Susceptibility Genes,
    and Fragile X Susceptibility Genes

93
International Collaborations
  • NIH Institutes and NIH Fogarty International
    Center
  • RFA on Identifying Autism Susceptibility Genes
    with many partners including
  • NIH NIMH, NINDS, NICHDS, NIEHS, NIDCD
  • CIHR INMHA, IHDCYH and IG
  • National Alliance for Autism Research
  • Health Research Board of Ireland
  • Southwest Autism Research and Resource Center
  • Cure Autism Now
  • Similar on Fragile X
  • Discussion Nanomedicine

94
International Collaborations
  • INMHA-IBRO Neurosciences Schools
  • Partnership with International Brain Research
    Organization to particularly support neuroscience
    schools in developing countries
  • African Advanced Neuroscience School
  • September 2003
  • Two Schools in 2004
  • Morocco and Argentina
  • Two Schools in 2005
  • Kenya and Argentina
  • For more details www.ibro.org

95
International Collaborations
  • National Alliance for Autism Research (U.S.)
  • Co-sponsor of two CIHR Strategic Training
    Programs in Autism Research
  • Eric Fombonne, McGill University
  • Jeannette Holden, Queens University
  • Partner in a RFA on Identifying Autism
    Susceptibility Genes with NIH, CIHR and many
    partners

96
International Collaborations
  • Canada-Finland-China Collaborative Program in
    Neuroscience
  • Joint Program with the Academy of Finland
  • MOU signed in Finland, Mar. 2005
  • Many grant applications received

97
International Collaborations
  • National Alliance for Schizophrenia and
    Depression (NARSAD) (U.S.)
  • Joint Young Investigator Awards 2004
  • Viau (UBC)
  • Misener (University of Toronto)
  • Dozois (UWO)
  • Savard (Laval)
  • Debruille (McGill)
  • Repeated in 2005
  • Meeting with NARSAD, Schizophrenia Society of
    Canada and Canadian Psychiatric Research
    Foundation (Toronto, Sept. 2005)

98
International Collaborations
  • WHO / PAHO
  • Mental Health and Addictions in the Developing
    World
  • WHO Centre in Gender and Mental Health (with IGH)

99
International Collaborations
  • Mexico
  • Memorandum of Understanding Signature in Ottawa
    on October 25, 2002
  • Institute of Neurology and Institute of
    Psychiatry
  • China
  • Discussions under way with National Science
    Foundation

100
INMHA Strategic Priority Three
  • Knowledge Translation

101
Knowledge Translation
  • Cunningham Modeling parent preferences for
    translating
  • (McMaster U) scientific knowledge regarding
    children with inter- nalizing and externalizing
    mental health problems
  • Forchuk (UWO) Integrating an evidence-based
    intervention in clinical practice
  • Manske Understanding and testing KT strategies
    in
  • (U of Waterloo) tobacco control evaluation at
    national, provincial and local levels
  • McVey Evaluation of a Web-based program
    designed to
  • (U of Toronto) evaluate the dissemination of
    best practice
  • models in the primary prevention of disorder
    eating
  • Varnhagen Strategies for critically appraising
    childrens health
  • (U of Alberta) web resources

102
Knowledge Translation
  • In partnership with IHSPR
  • Kisely (Dalhousie U) Measuring quality in mental
    health services across Nova Scotia evaluation of
    a demonstration site
  • Dewa (U Toronto-CAMH) Examining the
    effectiveness of a collaborative care model for
    individuals with severe mental illness

103
Other KT Initiatives
  • Neuroscience Schools in developing countries
    sponsored in collaboration with IBRO (2 Schools
    per year)
  • September 1-7, 2004 Cape Town, South Africa
  • September 13-30, 2004 Cordoba, Argentina
  • Topics in Cellular and Molecular Neuroscience
  • March 19-27, 2005      Rabat, Morocco
  • "Hormones and Brain
  • Nov. 19  - Dec. 6, 2005    Buenos Aires,
    Argentina
  • Receptors, Channels, and Synapses

104
Other KT Initiatives
  • Outreach Initiative 2004
  • Program aimed to help NGO with communication and
    dissemination of information to target audience
  • First edition in collaboration with IGH
  • Autism Society of Canada
  • Partners seeking solutions with seniors and
    Creative Retirement Manitoba
  • Canadian Alliance on Mental Illness and Mental
    Health
  • Canadian Mental Health Association, Ontario

105
Other KT Initiative
  • Outreach Initiative 2005
  • Autism Society of Ontario
  • Canadian Coalition for Seniors Mental Health
  • Center of Neurosciences Studies (Queens
    University)
  • Brain Awareness Week
  • INMHA sponsors BAW in Montreal,
    Saskatoon,Toronto, British Columbia, and Halifax

106
Other KT Initiatives
  • Web site The Brain from top to bottom
  • Link available on INMHA web page
  • www.cihr-irsc.gc.ca/e/8602.html
  • Web site designed to popularize scientific
    information about the brain and human behaviors
    and aimed at all public
  • Organized by topics and levels of explanation
  • Approximately 700 visitors/day

107
INMHA Strategic Priority Five
  • Effective Organizational and Operational Structure

108
INMHA Organizational andOperational Structure
  • Frequent IAB meeting with summaries on the Web
  • IAB organized in Focus Groups
  • Annual Meeting with all stakeholders
  • Quaterly Newsletter
  • Two staff dedicated to National and International
    Partnerships
  • Direct involvement in many CIHR committees and
    working groups

109
Recent and Upcoming Events
  • Comorbidity and co-occurrence consultation
    workshop Sept 22-23, 2005
  • First Performance Evaluation Report (Fall 2005)
  • Fourth Annual Meeting, Vancouver, October 2005
  • INMHA-STIHR Workshop in Montreal, Nov. 2005, with
    NAAR and FRSQ
  • Second Strategic Plan to be developed in
    2005-2006 in collaboration with partners

110
How to get in touch with us?
  • Astrid Eberhart, Assistant Director, Partnerships
    / International
  • aeberhart_at_cihr-irsc.gc.ca
  • Barbara Beckett, Assistant Director
  • bbeckett_at_cihr-irsc.gc.ca
  • Asimina Xidous, Project Officer
  • axidous_at_cihr-irsc.gc.ca
  • Eric Marcotte, Lead Lead
  • Regenerative Medicine
  • eric.marcotte_at_regenerativemedicine.ca
  • Montreal Office
  • Rémi Quirion, Scientific Director
  • remi.quirion_at_douglas.mcgill.ca
  • Richard Brière, Assistant Director
  • richard.briere_at_douglas.mcgill.ca
  • Ramia Jabr, Executive Manager
  • ramia.jabr_at_douglas.mcgill.ca
  • Rocio Benalcazar,
  • Administratrive Assistant
  • rocio.benalcazar_at_douglas.mcgill.ca

111
Visit us at...
www.cihr-irsc.gc.ca and read the Brain Brief,
INMHA newsletter www.thebrain.mcgill.ca and read
about the brain from top to bottom
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