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Grapefruit Juicy Details on Health Benefits and Drug Interactions

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Grapefruit 'Juicy' Details on Health Benefits and Drug Interactions ... Some pills become too potent when you drink grapefruit juice. Grapefruit juice and ... – PowerPoint PPT presentation

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Title: Grapefruit Juicy Details on Health Benefits and Drug Interactions


1
Grapefruit Juicy Details on Health Benefits
and Drug Interactions
Elaine Turner Gail Rampersaud, FSHN
2
Grapefruit Juice Interactions with Prescription
Drugs
  • R. Elaine Turner, PhD, RD
  • FSHN Department
  • University of Florida


3
Grapefruit Juice Whats the Story?
4
Grapefruit Juice Whats the Story?
Sex, drugs, and grapefruit
Some pills become too potent when you drink
grapefruit juice
Grapefruit juice and drugs dont mix
Forbidden Fruit? Grapefruit Juice-Medicine
Interaction Studied
Grapefruit Takes the Defense
5
Food/Drug Interactions
  • Food can affect
  • absorption
  • utilization
  • excretion
  • Influence can be
  • positive
  • negative

6
Effects of Grapefruit Juice
  • Enhances Absorption
  • inhibits an intestinal enzyme
  • less metabolism in GI tract
  • first-pass metabolism
  • like giving larger dose
  • larger effect of drug
  • Increased risk for side effects

7
Normal Drug Metabolism
ORAL DOSE
GI TRACT
ENZYME
LIVER
BLOOD
8
Effect of Grapefruit Juice
ORAL DOSE
GI TRACT
ENZYME
LIVER
BLOOD
9
Effects of Grapefruit Juice
  • Enzyme Inhibition
  • one of cytochrome P450 enzymes
  • CYP3A
  • minimal to no effect in liver

10
Effects of Grapefruit Juice
  • Are All Drugs Affected? no!
  • oral medications only
  • low bioavailability
  • first-pass metabolism by CYP3A in GI tract
  • amount of effect varies
  • individuals, medications

11
Effects of Grapefruit Juice
  • Which Types of Drugs are Affected?
  • Antihypertensives
  • Immunosuppressants
  • Statins
  • Anti-anxiety, Antidepressants
  • Antihistamines
  • HIV/AIDS protease inhibitors

12
Effects of Grapefruit Juice
  • Which Types of Drugs are Affected?
  • Usually an alternative drug is available
  • e.g., Pravachol instead of Lipitor

13
Consumer Actions
  • Ask Pharmacist
  • Is my medication affected by grapefruit juice?
  • Yes talk with MD before making changes
  • No no need to worry

14
Consumer Actions
  • Ask Physician
  • Is there an alternative medication I can take?

15
Take Home Message
  • Media Statements
  • Usually too general
  • Talk with pharmacist and physician
  • May not need to avoid grapefruit juice

Grapefruit juice and drugs dont mix
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