Important pathophysiologic mechanisms in HF 1

1
Important pathophysiologic mechanisms in HF (1)
Cardiac abnormalities
Functional
Structural

• Coronary arteries
• Obstruction
• Inflammation

• Left ventricular chamber
• Remodeling
• Dilation
• Increased sphericity
• Aneurysmal dilatation or wall
  thinning Concentric hypertrophy

• Myocardium or myocyte
• Myocardial relaxation
• Abnormal excitation- contraction coupling
• ?-Adrenergic desensitization
• Hypertrophy
• Necrosis
• Fibrosis
• Apoptosis

• Mitral regurgitation
• Intermittent ischemia or hibernating myocardium
• Induced arterial and ventricular arrhythmias
• Altered ventricular interaction

Modified from Jessup M, Brozena S. N Engl J Med.
20033482007-18.