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Center for Advancing Longitudinal Drug Abuse Research CALDAR

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Development and application of rigorous scientific approaches for advancing ... Toni Krupski. Sujaya Parthasarathy. Statistical Support & Data Management Core ... – PowerPoint PPT presentation

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Title: Center for Advancing Longitudinal Drug Abuse Research CALDAR


1
Center for Advancing Longitudinal Drug Abuse
Research (CALDAR)
Funded by The National Institute on Drug
Abuse September 2005 - August 2010
2
Center Overview
  • Purpose
  • CALDAR Overarching Theme
  • Conceptual Framework
  • Specific aims
  • Structure
  • Organizational Chart
  • Three Cores
  • Projects
  • Products
  • Year 1 Cross-project analyses
  • Other activities

3
CALDAR Overarching Theme
  • Development and application of rigorous
    scientific approaches for advancing longitudinal
    research on drug abuse and its interplay with HIV
    infection, drug treatment, and other service
    systems.

4
Why Is This Theme Important?
  • Disconnect in
  • Chronicity of the disorder and short-term/discrete
    observation/approach
  • Controlled studies and real world applications
  • Methodological challenges
  • Non/experimental observation
  • Multiple and interactive causes and effects
  • Data quality
  • Human subject issues
  • Longitudinal/multilevel statistical models

5
Conceptual Framework
6
Examples of Key Substantive Issues
  • How chronic drug use patterns evolve and interact
    with service systems?
  • Long-term disease management
  • How much treatment is needed for individuals
    whose problems are chronic?
  • What/how treatment should be if the previous one
    was unsuccessful?
  • Is there a threshold required for positive
    effects of treatment to emerge?
  • What effects are observable across multiple
    treatment episodes and different levels of care?
  • Health disparity

7
Specific Aims
  • Increase knowledge of longitudinal patterns of
    drug addiction and their interplay with HIV
    infection, drug treatment, and other service
    systems.
  • Enhance the quality and efficiency of research
    conducted by Center-supported projects by
    providing centralized support to serve common
    project functions.

8
Specific Aims, continued
  • Provide opportunities for scientific
    collaboration and cross-project analyses,
    stimulating conceptual development and
    integration, and advancing improved research
    methodologies and statistical approaches.
  • Enhance the relevance and application of
    longitudinal research on drug use by facilitating
    dissemination of integrated project findings to a
    variety of communities

9
Organizational Chart
10
Three Cores
  • Coordination Integration (CI) provides
    overall leadership for the Center projects and
    for administration and coordination across Cores
  • Research Support Development (RSD) enhances
    the conceptualization of and methodological
    approaches to longitudinal research.
  • Statistical Support Data Management (SSDM)
    provides support in statistics and data
    management

11
Research Development Core
  • Conceptual development and integration workgroup
  • Database acquisition workgroup
  • Regulatory affairs workgroup
  • Community advisory board

12
RSD Workgroups
13
Statistical Support Data Management Core
  • Consulting/training/technical assistance
  • Data acquisition management
  • Analytic strategies
  • Analytic support to cross-project analyses
  • Standards for data quality/documentation
  • Cross-walks for databases

14
Aims
  • Related to longitudinal analysis.
  • Consultation
  • Education
  • Analysis
  • Data accessibility/comparability

15
Consultation
  • Answer questions by CALDAR researchers, e.g.
  • Data acquisition and management of longitudinal
    data sets
  • Choice of analytic methods for longitudinal
    analysis (HLM, mixed models, growth models, GEE,
    SEM)
  • Setting up analyses
  • Interpretation of results
  • Compare methods
  • Create guidelines and examples for analysis
  • Develop algorithms for power analysis
  • Web links to other stat resources

16
Education
  • Workshops on stat methods related topics, by
    CALDAR staff and guest researchers
  • Workshop on longitudinal applications to be
    proposed for CPDD
  • Summer Instituteanalysis (2007)

17
Analysis
  • Cross-project analyses, e.g.
  • Long-term drug use and cessation (trajectories)
  • Drug treatment effects over time
  • Interplay with criminal justice
  • Drug users with mental health disorder

18
Data Accessibility/Comparability
  • Develop standards for documentation, quality
    assurance
  • Develop crosswalks for CALDAR data sets
  • Enhance ISAP data mgt. capabilities

19
SSDMC Structure
  • L. Brecht, Core Director
  • D. Huang, Core Assoc. Director Sr. Statistician
  • To-be-named/hired (partial FTEs)
  • Sr. statistician
  • Statistician/data manager
  • Research admin assistants
  • Consultants
  • Bengt Muthen
  • Linda Collins
  • Chi-Ping Chou

20
41 Longitudinal Studies
  • 10 active ISAP/UCLA projects
  • 8 external collaborators active projects
  • 9 longitudinal studies under review
  • 18 recently completed projects
  • 13 archived projects

21
ISAP/UCLA Active Projects
  • L. A. County Evaluation System An Outcomes
    Reporting Program (LACES)
  • Evaluation of California Substance Abuse
    Treatment Facility (SATF)
  • Substance Abuse and Crime Prevention Act (SACPA)
    Evaluation
  • Evaluation of Female Offender Treatment and
    Employment Program (FOTEP)
  • Pacific Coast Research Center of the NIDA CJ-DATS
  • Treatment System Impact and Outcomes of
    Proposition 36 (TSI)
  • HBV Prevention for Homeless At-risk for
    HBV/HCV/HIV
  • Course of Problems in Adolescent Drug Treatment
    Intakes
  • Integrated Drug and Medical Care-Cost and
    Effectiveness
  • Motivational Intervention with Drug-using Facial
    Injury Patient

22
Center Products
  • Serve as a national resource on longitudinal drug
    abuse research
  • Develop and make widely available training and
    educational program materials (e.g., workshops,
    seminars, website)
  • Four cross-project analyses per year
  • Two journal special issues
  • Publications and grant applications

23
Centralized Support
  • Common instruments/measures
  • Administrative records acquisition
  • Human subjects
  • Analytic support

24
Cross-project Analyses
  • Priority Areas
  • Drug use/HIV
  • Treatment
  • CJS
  • Mental health
  • First year
  • Subsequent years, prioritized by
  • Multiple projects/databases
  • Multiple observations
  • Health services

25
First Year Cross-project Analyses
  • Nine archived datasets/projects
  • Natural History Interview and Addiction Severity
    Index measures
  • Administrative records
  • Analyses
  • Long-term drug use and cessation
  • Drug treatment effects over time
  • Interplay with criminal justice
  • Drug users with mental health disorders or HIV

26
First year cross-study analyses
  • Methamphetamine Natural History (Brecht/Anglin)
  • Multi-site Methamphetamine Follow-up
    (Marinelli-Casey/Rawson)
  • 33-year Heroin Follow-up (Hser/Anglin)
  • 12-year Cocaine Follow-up (Hser/Anglin/Stark/Rawso
    n/Paredes)
  • Treatment Utilization Evaluation
    (Hser/Longshore/Anglin)
  • Long-term Impact of Drug Treatment on Outcome
    Cost (Weisner)
  • Integrated Drug Medical Care (Weisner)
  • Dual Diagnosis (Grella/Anglin/Hser)
  • Long-term Course of Treatment Untreated Alcohol
    Abuse (Moos)

27
Cross-projects Analyses(challenges)
  • Comparability across projects
  • Measures
  • Assessment time points and periods
  • Data sources
  • Analytic strategies for causal inferences

28
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29
Growth Model with Time-Invariant Time-Varying
Covariates
30
Drug use Growth Mixture Model
31
Other activities
  • Consulting/training/technical assistance
  • Internal
  • External, via Website
  • Educational workshop
  • CPDD
  • R13 application
  • Dissemination
  • CPDD presentations
  • Review articles
  • Other conference presentations

32
Committees
33
Center meetings
  • External
  • Scientific advisory board
  • Community advisory board
  • Internal
  • Executive committee/project committee
  • Research core workgroups
  • Dissemination committee
  • Training development committee
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