Title: Center for Advancing Longitudinal Drug Abuse Research CALDAR
1Center for Advancing Longitudinal Drug Abuse
Research (CALDAR)
Funded by The National Institute on Drug
Abuse September 2005 - August 2010
2Center Overview
- Purpose
- CALDAR Overarching Theme
- Conceptual Framework
- Specific aims
- Structure
- Organizational Chart
- Three Cores
- Projects
- Products
- Year 1 Cross-project analyses
- Other activities
3CALDAR Overarching Theme
- Development and application of rigorous
scientific approaches for advancing longitudinal
research on drug abuse and its interplay with HIV
infection, drug treatment, and other service
systems.
4Why Is This Theme Important?
- Disconnect in
- Chronicity of the disorder and short-term/discrete
observation/approach - Controlled studies and real world applications
- Methodological challenges
- Non/experimental observation
- Multiple and interactive causes and effects
- Data quality
- Human subject issues
- Longitudinal/multilevel statistical models
5Conceptual Framework
6Examples of Key Substantive Issues
- How chronic drug use patterns evolve and interact
with service systems? - Long-term disease management
- How much treatment is needed for individuals
whose problems are chronic? - What/how treatment should be if the previous one
was unsuccessful? - Is there a threshold required for positive
effects of treatment to emerge? - What effects are observable across multiple
treatment episodes and different levels of care? - Health disparity
7Specific Aims
- Increase knowledge of longitudinal patterns of
drug addiction and their interplay with HIV
infection, drug treatment, and other service
systems. - Enhance the quality and efficiency of research
conducted by Center-supported projects by
providing centralized support to serve common
project functions.
8Specific Aims, continued
- Provide opportunities for scientific
collaboration and cross-project analyses,
stimulating conceptual development and
integration, and advancing improved research
methodologies and statistical approaches. - Enhance the relevance and application of
longitudinal research on drug use by facilitating
dissemination of integrated project findings to a
variety of communities
9Organizational Chart
10Three Cores
- Coordination Integration (CI) provides
overall leadership for the Center projects and
for administration and coordination across Cores - Research Support Development (RSD) enhances
the conceptualization of and methodological
approaches to longitudinal research. - Statistical Support Data Management (SSDM)
provides support in statistics and data
management
11Research Development Core
- Conceptual development and integration workgroup
- Database acquisition workgroup
- Regulatory affairs workgroup
- Community advisory board
12RSD Workgroups
13Statistical Support Data Management Core
- Consulting/training/technical assistance
- Data acquisition management
- Analytic strategies
- Analytic support to cross-project analyses
- Standards for data quality/documentation
- Cross-walks for databases
14Aims
- Related to longitudinal analysis.
- Consultation
- Education
- Analysis
- Data accessibility/comparability
15Consultation
- Answer questions by CALDAR researchers, e.g.
- Data acquisition and management of longitudinal
data sets - Choice of analytic methods for longitudinal
analysis (HLM, mixed models, growth models, GEE,
SEM) - Setting up analyses
- Interpretation of results
- Compare methods
- Create guidelines and examples for analysis
- Develop algorithms for power analysis
- Web links to other stat resources
-
16Education
- Workshops on stat methods related topics, by
CALDAR staff and guest researchers - Workshop on longitudinal applications to be
proposed for CPDD - Summer Instituteanalysis (2007)
-
17Analysis
- Cross-project analyses, e.g.
- Long-term drug use and cessation (trajectories)
- Drug treatment effects over time
- Interplay with criminal justice
- Drug users with mental health disorder
18Data Accessibility/Comparability
- Develop standards for documentation, quality
assurance - Develop crosswalks for CALDAR data sets
- Enhance ISAP data mgt. capabilities
-
19SSDMC Structure
- L. Brecht, Core Director
- D. Huang, Core Assoc. Director Sr. Statistician
- To-be-named/hired (partial FTEs)
- Sr. statistician
- Statistician/data manager
- Research admin assistants
- Consultants
- Bengt Muthen
- Linda Collins
- Chi-Ping Chou
2041 Longitudinal Studies
- 10 active ISAP/UCLA projects
- 8 external collaborators active projects
- 9 longitudinal studies under review
- 18 recently completed projects
- 13 archived projects
21ISAP/UCLA Active Projects
- L. A. County Evaluation System An Outcomes
Reporting Program (LACES) - Evaluation of California Substance Abuse
Treatment Facility (SATF) - Substance Abuse and Crime Prevention Act (SACPA)
Evaluation - Evaluation of Female Offender Treatment and
Employment Program (FOTEP) - Pacific Coast Research Center of the NIDA CJ-DATS
- Treatment System Impact and Outcomes of
Proposition 36 (TSI) - HBV Prevention for Homeless At-risk for
HBV/HCV/HIV - Course of Problems in Adolescent Drug Treatment
Intakes - Integrated Drug and Medical Care-Cost and
Effectiveness - Motivational Intervention with Drug-using Facial
Injury Patient
22Center Products
- Serve as a national resource on longitudinal drug
abuse research - Develop and make widely available training and
educational program materials (e.g., workshops,
seminars, website) - Four cross-project analyses per year
- Two journal special issues
- Publications and grant applications
23Centralized Support
- Common instruments/measures
- Administrative records acquisition
- Human subjects
- Analytic support
24Cross-project Analyses
- Priority Areas
- Drug use/HIV
- Treatment
- CJS
- Mental health
- First year
- Subsequent years, prioritized by
- Multiple projects/databases
- Multiple observations
- Health services
25First Year Cross-project Analyses
- Nine archived datasets/projects
- Natural History Interview and Addiction Severity
Index measures - Administrative records
- Analyses
- Long-term drug use and cessation
- Drug treatment effects over time
- Interplay with criminal justice
- Drug users with mental health disorders or HIV
26First year cross-study analyses
- Methamphetamine Natural History (Brecht/Anglin)
- Multi-site Methamphetamine Follow-up
(Marinelli-Casey/Rawson) - 33-year Heroin Follow-up (Hser/Anglin)
- 12-year Cocaine Follow-up (Hser/Anglin/Stark/Rawso
n/Paredes) - Treatment Utilization Evaluation
(Hser/Longshore/Anglin) - Long-term Impact of Drug Treatment on Outcome
Cost (Weisner) - Integrated Drug Medical Care (Weisner)
- Dual Diagnosis (Grella/Anglin/Hser)
- Long-term Course of Treatment Untreated Alcohol
Abuse (Moos)
27Cross-projects Analyses(challenges)
- Comparability across projects
- Measures
- Assessment time points and periods
- Data sources
- Analytic strategies for causal inferences
28(No Transcript)
29Growth Model with Time-Invariant Time-Varying
Covariates
30Drug use Growth Mixture Model
31Other activities
- Consulting/training/technical assistance
- Internal
- External, via Website
- Educational workshop
- CPDD
- R13 application
- Dissemination
- CPDD presentations
- Review articles
- Other conference presentations
32Committees
33Center meetings
- External
- Scientific advisory board
- Community advisory board
- Internal
- Executive committee/project committee
- Research core workgroups
- Dissemination committee
- Training development committee
-