Review Session

1
Review Session Monday 6 pm BI 234 Final Exam
Wednesday 1030 am
2
Stryer Fig. 15.22 Conformational changes upon
ion binding
3
What does this prefix mean?
Stryer Fig. 15.23 Calmodulin binds amphipathic
helices of CM kinase
4
Stryer Fig. 15.24
5
(shown in yellow)
Stryer Fig. 15.25
6
Stryer Fig. 15.25
7
Helps anchor kinase to membrane
SH src homology domain 100 aa domains that bind
phosphotyr. Src is a gene from Raus Sarcoma
Virus that codes for a tyr PK which induces
uncontrolled cell growth.
Stryer Fig. 15.26 Janus Kinase (Janus Roman god
of doorways, of expeditions, of setting the feet
free)
8
Stryer Fig. 15.27
9
Stryer Fig. 15.28 Dimerization brings JAKs into
proximity to phosphorylate each other!
10
Stryer Fig. 15.29
11
Stryer Fig. 15.30 JAK phosphorylates other
proteins-- like STAT (signal transducers and
activators of transcription
12
Disulfide bonds
Stryer Fig. 15.31
13
Binds receptor
Binds pro-rich regions of other proteins like
Sos. Sos in turn activates Ras
Stryer Fig. 15.32 Grb-2 an adaptor protein
14
Stryer Fig. 15.33 Sos and Ras association
promotes GTP binding to Ras. GTP-Ras can
activate other PKs.
15
(No Transcript)
16
Stryer Fig. 15.34
17
Stryer Fig. 15.35 Src
18
Stryer Fig. 15.36 Activation of c-Src
19
(No Transcript)
20
Stryer Fig. 15.38 Pathway conservation