Who gets fibrosis The role of genetic and epigenetic influences

1
Who gets fibrosis?The role of genetic and
epigenetic influences

• John P Iredale,
• Professor of Medicine and Director of Research,
• School of Medicine Southampton UK

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Who gets fibrosis?The role of genetic and
epigenetic influences

• Answers
• Patients with chronic liver disease
• Both genetic and epigenetic influences are likely
  to exact a significant influence on the extent
  severity and progression of fibrosis.

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Fibrosis a disorder characterised by changes in
cell phenotype and synthetic behaviour
ACTIVATED HSC
QUIESCENT HSC
Number HSC Collagen
HC KC INFC
Paracrine factors, stimuli from damaged
cells, Activated clotting factors
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Fibrosis a disorder characterised by changes in
cell phenotype and synthetic behaviour
Major Genetic influences
NIDDM/metabolic syndrome
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Fibrosis a disorder characterised by changes in
cell phenotype and synthetic behaviour
Altered matrix degradation (mmp3)
Prothrombotic tendency (fact V Leiden)
Possible Genetic influences
Cytokines (tgfb1)
Inflammation (Th1/2)