Discussion 19 Glycobiology and Infection

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Discussion 19Glycobiology and Infection
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Infection

• Infection involves three steps
• Adhesion mediated through adhesins (Colonization)
• Invasion and Dissemination
• Microbial Defense
• Inflammatory Response

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Dengue Virus
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Influenza Virus
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Fig. 34.4
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FimH
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Infection

• Infection involves three steps
• Adhesion mediated through adhesins (Colonization)
• Invasion and Dissemination
• Microbial Defense
• Inflammatory Response

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HSPGs Signal to Plasmodium Sporozoites to Stop
Migrating and Invade Host Cells
Coppi A et al. Cell Host Microbe. 2007 2316
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Cholera Toxins
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Anti-Adhesion Therapy
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Infection

• Infection involves three steps
• Adhesion mediated through adhesins (Colonization)
• Invasion and Dissemination
• Microbial Defense
• Inflammatory Response

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Survival Tactics
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Alpha Toxins of Clostridium Species
Actin condensation, cell rounding, inflammatory
response, apoptosis
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Infection

• Infection involves three steps
• Adhesion mediated through adhesins (Colonization)
• Invasion and Dissemination
• Microbial Defense
• Inflammatory Response

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Host response - Pattern Recognition Receptors
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