Red cell and plasma plant sterols are

1
Red cell and plasma plant sterols are related
during consumption of plant stanol and sterol
ester spreads in children with hypercholesterolemi
a Ketomäki AM et al. J Pediatr. 2003142524-31.
2
Rationale

• There are some differences between stanol esters
  and sterol esters that have already been
  described (e.g. better long-term results of
  stanol ester in Miettinen et al. 1995 vs.
  Hendriks et al. 2003)
• The aim of the study was to investigate the
  differential effects of consuming plant sterol
  ester or plant stanol ester spreads on serum and
  red blood cell sterols in hypercholesterolaemic
  children

DALY disability-adjusted life years
Ketomäki AM et al. J Pediatr. 2003142524-31.
3
Design

• Randomised, double-blind, crossover study
• Stanol 2 g/d

Ketomäki AM et al. J Pediatr. 2003142524-31.
4
Patient population

• Inclusion criteria
• Age 2-9 years
• Serum total cholesterol gt194 mg/dl
• Serum triglycerides lt176 mg/dl

Ketomäki AM et al. J Pediatr. 2003142524-31.
5
Protocol
Ketomäki AM et al. J Pediatr. 2003142524-31.
6
Results I
Stanol
Sterol
Figure 1.Significant LDL lowering.
Ketomäki AM et al. J Pediatr. 2003142524-31.
7
Results II
Stanol
Sterol
Figure 2.Consumption of stanol lowers sterol to
cholesterol ratio of red cells.
Ketomäki AM et al. J Pediatr. 2003142524-31.
8
Conclusion

• Consumption of plant sterols increases and
  consumption of plant stanols decreases the ratio
  of plant sterols to cholesterol in red cells of
  hypercholesterolaemic children, proportionately
  to the respective changes in plasma

DALY disability-adjusted life years
Ketomäki AM et al. J Pediatr. 2003142524-31.
9
Editors note

• Because of their safety and lack of side effects,
  plant stanol ester enriched functional foods are
  optimal for cholesterol management in children
  with familial lipid disorders

DALY disability-adjusted life years
Ketomäki AM et al. J Pediatr. 2003142524-31.