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Neurotransmitters: Catecholamines

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vesicular monoamine transporter protein (VMAT2) Behavioral effects of reserpine ... Discovery of MPPP MPTP and MPP A typical dopaminergic neuron. D1 and D2 receptors ... – PowerPoint PPT presentation

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Title: Neurotransmitters: Catecholamines


1
NeurotransmittersCatecholamines
AcetylcholineChapters 5 6
  • Catecholamines
  • Dopamine
  • Norepinephrine
  • Epinephrine
  • Acetylcholine
  • Serotonin
  • Glutamate
  • GABA

2
Neurotransmitter Families
Neurotransmitters
3
Structural features of catecholamines
4
Synthesis of Catecholamines
rate-limiting enzyme
5
CatecholeminesSome adjectives
  • Dopamine (DA)
  • dopaminergic
  • Norepinephrine (NE)
  • noradrenergic
  • Epinephrine (EPI)
  • adrenergic

6
Storage of Catecholaminesvesicular monoamine
transporter protein (VMAT2)
7
Behavioral effects of reserpine
http//home.caregroup.org/clinical/altmed/interact
ions/Images/Herbs/rauwolfi.gif
8
Dopamine Systems in the Brain
  • Mesolimbic pathway
  • Reinforcement
  • Mesocortical pathway
  • Planning
  • Nigrostriatal pathway
  • Movement

9
Symptoms of Parkinsons Disease
  • Difficulty moving
  • Tremor in resting body parts
  • Loss of balance, frequent falls
  • Cognitive dysfunctions in memory, abstract
    thinking, language
  • Premature death

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10
Damage to the substantia nigra
http//www.urmc.rochester.edu/neuroslides/slides/s
lide199.jpg
11
Causes of Parkinsons Disease
  • Degeneration of substantia nigra
  • Less dopaminergic activity in basal ganglia
  • Discovery of MPPP ? MPTP and MPP

12
A typical dopaminergic neuron
13
D1 and D2 receptors
14
Catalepsy can be produced by D2 receptor
antagonists
15
Norepinephrine
http//homepage.psy.utexas.edu/homepage/class/Psy3
01/Salinas/sec2/Brain/31.GIF
16
Role of the locus coeruleus in vigilance
17
Synthesis of acetylcholine (ACh)
18
Functions of Acetylcholine (ACh)
  • Neuromuscular junction (movement)
  • Central nervous system (learning and memory)

19
cholinergic synapse
20
Acetylcholine Receptors
  • Nicotinic receptors
  • Neuromuscular junctions
  • Ionotropic (ion channel)
  • Curare works on these receptors
  • Muscarinic receptors
  • Metatropic (second messengers)
  • Hippocampus, striatum
  • Morphine
  • Also located in heart and smooth muscles
  • Nightshade

21
Cholinergic synapses in the parasympathetic and
sympathetic branches of the ANS
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