Antigen-presenting cell (APC) phagocytizes and processes antigen

1
Allergen (antigen)
1
Antigen-presenting cell (APC) phagocytizes and
processes antigen
2
Allergen (antigen)
2
APC presents antigenic determinant to TH2 cell
TH2 cell
1
Antigen-presenting cell (APC) phagocytizes and
processes antigen
3
Allergen (antigen)
2
APC presents antigenic determinant to TH2 cell
3
IL-4 from TH2 cell stimulates B cell
TH2 cell
1
Antigen-presenting cell (APC) phagocytizes and
processes antigen
IL-4
B cell
4
Allergen (antigen)
2
APC presents antigenic determinant to TH2 cell
3
IL-4 from TH2 cell stimulates B cell
TH2 cell
1
Antigen-presenting cell (APC) phagocytizes and
processes antigen
IL-4
B cell
4
B cell becomes plasma cell, which secretes IgE
Plasma cell
IgE
5
Allergen (antigen)
2
APC presents antigenic determinant to TH2 cell
3
IL-4 from TH2 cell stimulates B cell
TH2 cell
1
Antigen-presenting cell (APC) phagocytizes and
processes antigen
IL-4
B cell
4
B cell becomes plasma cell, which secretes IgE
Plasma cell
IgE
5
IgE binds to mast cells, basophils, and
eosinophils
IgE
Eosinophil
Mast cell
Basophil