The Blood Clotting Cascade

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The Blood Clotting Cascade

• Manfred MaitzFZ-Rossendorf
• www.manfred.maitz-online.de

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The Clotting Cascade
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The Clotting Cascade
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Serine Proteases
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The Fibrinolytic System
Clotting Cascade
Fibrin degradation products
Fibrinogen
Fibrin-clot
Plasmin
Plasminogen
T-PAF XIIaHMWKKallikreinUrokinaseStreptokinas
e
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Effect of Antithrombin III/Heparin
Intrinsic Pathway
Extrinsic Pathway
Surface Contact Collagen FXII activator
Tissue/Cell Defect
F XIIa
F XII
F VII
F VIIa
Ca2
F XIa
F XI
Ca2
F IXa
F IX
F III (Tissue Thromboplastin)
Ca2
F VIIIa
F VIII
Platelet Factor 3
Factor F Xa
Factor F X
Factor F X
Ca2
Ca2
Prothrombin I
Thrombin
Ca2
F XIIIa
F XIII
Fibrinmonomers
Fibrinpolymers
Fibrinogen
CrosslinkedFibrin Meshwork
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Thrombin Time (TT)
Intrinsic Pathway
Extrinsic Pathway
Surface Contact Collagen FXII activator
Tissue/Cell Defect
F XIIa
F XII
F VII
F VIIa
Ca2
F XIa
F XI
Ca2
F IXa
F IX
F III (Tissue Thromboplastin)
Ca2
F VIIIa
F VIII
Platelet Factor 3
Factor F Xa
Factor F X
Factor F X
Ca2
Ca2
Prothrombin I
Thrombin
Ca2
F XIIIa
F XIII
Fibrinmonomers
Fibrinpolymers
Fibrinogen
CrosslinkedFibrin Meshwork
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The Quick (PT)-Test
Intrinsic Pathway
Extrinsic Pathway
Surface Contact Collagen FXII activator
Tissue/Cell Defect
F XIIa
F XII
F VII
F VIIa
Ca2
F XIa
F XI
Ca2
F IXa
F IX
F III (Tissue Thromboplastin)
Ca2
F VIIIa
F VIII
Platelet Factor 3
Factor F Xa
Factor F X
Factor F X
Ca2
Ca2
F V
F Va
Prothrombin I
Thrombin
Ca2
F XIIIa
F XIII
Fibrinmonomers
Fibrinpolymers
Fibrinogen
CrosslinkedFibrin Meshwork
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Partial Thromboplastin Time (a)PTT
Intrinsic Pathway
Extrinsic Pathway
Surface Contact Collagen FXII activator
Tissue/Cell Defect
F XIIa
F XII
F VII
F VIIa
Ca2
F XIa
F XI
Ca2
F IXa
F IX
F III (Tissue Thromboplastin)
Ca2
F VIIIa
F VIII
Platelet Factor 3
Factor F Xa
Factor F X
Factor F X
Ca2
Ca2
F V
F Va
Prothrombin I
Thrombin
Ca2
F XIIIa
F XIII
Fibrinmonomers
Fibrinpolymers
Fibrinogen
CrosslinkedFibrin Meshwork
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Surface Sensitive Steps
Intrinsic Pathway
Extrinsic Pathway
Surface Contact Collagen FXII activator
Tissue/Cell Defect
F XIIa
F XII
F VII
F VIIa
Ca2
F XIa
F XI
Ca2
F IXa
F IX
F III (Tissue Thromboplastin)
Ca2
F VIIIa
F VIII
Platelet Factor 3
Factor F Xa
Factor F X
Factor F X
Ca2
Ca2
Prothrombin I
Thrombin
Ca2
F XIIIa
F XIII
Fibrinmonomers
Fibrinpolymers
Fibrinogen
CrosslinkedFibrin Meshwork