Glutamine and TPN

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Glutamine and TPN

• Karnesh Patel

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Total Parenteral Nutrition

• Why
• How
• Complications

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Daily Basic Requirements

• Energy
• Protein
• Fluid
• Electrolytes
• Fat
• Vitamins
• Amino acids

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Glutamine

• Genetically coded
• Most naturally abundant, non-essential amino acid
• Sources
• Functions

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Usefulness

• Acute pancreatitis
• Inflammatory bowel disease
• Cholecystectomy

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Summary

• TPN useful when other means of feeding not
  possible
• TPN gives basic daily requirements of nutrients
• Glutamine aids immune function, prevents muscle
  catabolism, helps protein synthesis
• Glutamine may reduce inflammtion, LOS, and
  duration of TPN in acute pancreatitis
• Glutamine may be of use in other surgical
  conditions, but no/limited evidence