Experimental Annotations in ROC

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Experimental Annotations in ROC

• Russ Altman, Alain Laederach
• Based on our experiences with RiboWeb and our
  participation in a Program Project Grant

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Chalk Talk
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Structural Information

• PDB
• Evidence for Structural Motifs
• Base Pairs, Long range interactions etc.
• Experiments
• Many Biochemists getting more or less accurate
  structural evidence as well
• DMS Footprinting, Hydroxyl Radical Footprinting
• Tethered BABE probes, FRET, NMR, EPR
• Even computational folks predict structure
• Phylogenetic co-variance analysis
• M-Fold

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A possible hierarchy
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Why is this useful?

• We can populate instances from PDB
• We can also populate from experiments
• Biochemical
• Computational
• For structure prediction
• Make PDB from ensemble of biochemical data