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HRT after breast cancer

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HRT after breast cancer. Is it Safe ? Why? Controversy. Observational studies misleading ... HRT increases risk of breast cancer in post menopausal women ... – PowerPoint PPT presentation

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Title: HRT after breast cancer


1
HRT after breast cancer
  • Is it Safe ?

2
Why?
  • Controversy
  • Observational studies misleading
  • Further studies may not get ethics approval

3
.
  • Habits study conducted in sweden
  • Published in Lancet february 2004

4
study
  • RCT
  • Postmenopausal women
  • Tis -stage 2 breast cancer
  • One group given HRT
  • Follow up 2.1 years
  • Any new breast cancer event

5
results
  • Total 345 patients
  • 26/174 on HRT developed CA
  • 7/171 (not on hrt) developed ca
  • Trial stopped

6
strengths
  • Randomised
  • Prospective
  • Well defined clinical goal

7
weakness
  • Unblinding
  • Lack of placebo controls
  • No defined restaging

8
characteristics
9
recommendation
  • HRT increases risk of breast cancer in post
    menopausal women
  • Alternative non hormonal options should be
    considered when treating post menopausal symptoms
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