Genomewide Association Study CaseControl Study of Bipolar Disorder

1
Genome-wide Association StudyCase-Control Study
of Bipolar Disorder

• 2,000 established bipolar cases compared with
  3,000 controls
• Microarray-based technology
• Strongest signal at Chromosome 16p12
• Several genes at this locus could have relevance
  to BPD
• PALB2 involved in stability of nuclear
  structures (chromatin, nuclear matrix)
• NDUFAB1 encodes a subunit of Complex I of the
  mitochondrial respiratory chain
• DCTN5 encodes a protein involved in
  intracellular transport interacts with DISC1
  implicated in schizophrenia
• Other loci of interest
• KCNC2 encodes a voltage-gated potassium channel
• GABRBI GABA A receptor
• GRM7 metabotropic glutamate receptor
• SYN3 synapsin III

The Wellcome Trust Case Control Consortium.
Nature. 2007447(7)661-683.