Lecture on Health Knowledge of Bone

1
Lecture on Health Knowledge of Bone Joint
Lecturer
2

• Osteoarthritis, named
• rheumatism involving bone by Traditional
  Chinese Medicine physician, is the health
  killer to middle ages and elders.

3

• What is osteoarthritis?
• Osteoarthritis, also known as degenerative
  arthritis, hyperplasia osteoarthritis or aging
  osteoarthritis, is a kind of degenerative change
  due to softened, disintegrated or locally
  denudated cartilage matrix of joint as well as
  insecondary hyperosteogeny at the joint edge.

4

• It is characterized by joint pain and
  dysfunction, including joint malformation.
  Generally, diseases, including spur,
  hyporosteogeny, bowleg, cervical spondylosis,
  rheumatism, rheumatoid arthritis, for example,
  slipped disc caused by degenerative change all
  fall into the category of osteoarthritis.

5

• Status of Osteoarthritis
• Osteoarthritis is neither so serious as
  cancer and AIDS nor so recognized as heart
  disease and diabetes, but it troubles people,
  racks patients, and ranks 1st among chronic
  diseases which disables adults.

6

• Status of Osteoarthritis
• Approximate 100,000,000 Chinese, which
  accounts for 10 per cent of the national
  population now suffer from osteoarthritis. Being
  common among middle ages, elders and specific
  occupations, including athlete and teacher and on
  the rise among general population, it becomes the
  major chronic disease which disables us and
  affects our health and living quality.

7

• As a chronic disease, osteoarthritis requires a
  long period of treatment. Due to joint
  dysfunction, patients are restricted for movement
  and shall be replaced with artificial joints in
  the late stage, which impairs patients living
  and work ability greatly and brings heavy
  financial burden to patients and their families.
  According to statistics, by 1999, approximately
  16,000,000 Americans out of the overall
  population of 280,000,000 suffer from
  osteoarthritis, the annual outpatients reach
  80,000,000 person trips and 600,000 surgeries are
  performed. The annual average treatment expense
  is up to USD2,000 3,000 per capita.

8

• ?The probability of disability
  resulting from arthritis is high.
  Critical patients
• lose capability for working and independent
  living.
• ?Arthritis is named Undying Cancer by WHO
• ?Arthritis restricts the movement of middle ages
  and elders and tends to induce cardiovascular and
  cerebrovascular diseases and diabetes after
  sitting for a long while.

9

• In November 1999, it is officially approved by
  UN Secretary-General Kofi Annan that 2000-2010 is
  defined as the Bone Joint Decade, subsequently,
  the Bone Joint Decade Plan is started by WHO
  and every 12th October is named the International
  Arthritis Day.

10

• Causes
• Man cant stand without bone that cant move
  without joint.
• The typical structure of movable joint is
  comprised of articular surface, cartilage, cavity
  and capsule.

Articular cartilage
Where articular cartilage is the most important
component.
11

• 1. Normal Articular Cartilage

Articular cartilage is a layer of smooth and
elastic tissue with 2-7mm of thickness covering
on articular surface. Working as a buffer with
decent elasticity or a perfect cushion between
joints, it bears various high-loading pressures
and impacts in cycle in our life. Healthy
articular cartilage guarantees the free motion of
the joint as well as buffers and protects the
joint by absorbing vibration energy resulting
from motion.
12

• 2. Abnormal Articular Cartilage

With age, the articular cartilage of our body is
worn, lost and degenerated inevitably. As being
used and consumed over time, much more articular
cartilage is lost, but the self restoring and
rebuilding capacity is declining. In this case, a
part of cartilage becomes softened, eroded,
thinner and even disarticulated to produce a
tough surface and hyperosteogeny at the edge. For
lack of protection from cartilage, pressure
between joints increases, pain, swelling,
stiffness, sound or friction is occurred to the
joint both in still or in motion, and we will
fail to move as free as we did before.
13

• Osteoarthritis
• Ached in the joint, rooted in the cartilage

14

• Clinical Manifestation
• Symptom
• It is mainly demonstrated by red, swollen,
  heat, aching and dysfunction at the joint in
  question, which becomes sensitive to change of
  temperature and humidity in the climate.
• Early stage patient feels slight discomfort
  and annoyed.
• Common patient feels stiff, unbearable ache,
  and be tired for walking up and down stairs.
• Critical patient the joint is deformed, and
  the joint moving range is reduced.

15

• Main Symptoms
• 1. Ache, Swelling
• Ache is generally occurred in motion
• and be exacerbated when walking up
• and down and being loaded. Patients
• are always waken by ache at night and
• kept awaken the night through. With
• ache, the joint motion is accompanied
• by sound or friction frequently.

16

• 2. Restricted Motion
• It occurs slowly.
• In fact, a great number of middle ages and
  elders feel stiff in the joint when getting up in
  the morning, several minutes or longer time is
  required for restoration. Such phenomenon is
  called morning stiffness.
• Patient feels stiff and ache in the joint
  when standing up after a long time of sitting,
  and is only allowed to move after minutes of
  massage. So patients may fail to stand up at once
  in emergency.

17

• 3.Dysfunction
• With the growth of osteoarthritis, the joint
  will become deformed or disabled for motion, and
  finally lose all functions. Joints in critical
  conditions shall be replaced with artificial
  ones.

18

• Are you annoyed for
• feeling ache at waist and legs in doing exercise?
• feeling difficult in walking up and down stairs?
• failing to have a trip?
• daring not to turn over in the bed?

Unfortunately, you may be in trouble with
osteoarthritis if the motion of your joint is
always accompanied by ache, dryness,
inflexibility or even swelling and stabbing
19

• Location
• Osteoarthritis may be occurred to joints at any
  part of the body from head to foot. Typically, it
  is concentrated in cervical spine, hand, lumbar
  spine, knee and ankle joints.

20

• X-ray film
• 1. narrow gap between joints
• 2. hyperosteogeny at the edge, i.e. spur
• 3. hardened lower cartilage and degenerated
  capsule.
• Clinical symptoms of osteoarthritis are not
  necessary consistent with those illustrated by
  the X-ray film. In practice, approximate 50 per
  cent patients who suffering from osteoarthritis
  carries no distinctive symptom.

21

• Pathogenesis
• 1. The cartilage is degenerated and tenuated
  with the age, but the self restoring capacity is
  decreased. The incidence of osteoarthritis grows
  as human and society become aged since aging
  takes the most important contribution for
  osteoarthritis.
• 2. The joint fails to bear pressures from
  the body, and bones conflict with each other
  without buffer. Obese people due to excess
  nutrients and unscientific dietary habits in
  modern society are much likely to suffer from
  Osteoarthritis.
• 3. The incidence rate is high among special
  occupants, including athlete, teacher, dancer,
  miner, female textile worker because joints are
  over used and damaged frequently.
• 4. Osteoarthritis caused by infection, low
  immunity or wound, etc.

22

• a.
• It is found by medical research that
  glucosamine is the basis of articular cartilage.
  It is the raw material for composing and
  producing cartilage and fluid and stimulates the
  generation of cartilage cell for new cartilage.
• The cartilage starts to aging since 25. With
  the growth of our age, glucosamine is reduced
  from the body, which may directly result in
  metabolic disturbance of cartilage cells
  meanwhile decomposition is faster than
  composition, the rebuilding and repairing
  capability is decreasing, cartilage cells are
  damaged or destroyed, and cartilage is worn,
  degenerated and lost over time so that leads to
  the degenerative change of articular cartilage
  and symptoms of osteoarthritis.

23

• b.
• Loss of bone calcium is one of the key factors
  for osteoarthritis
• Healthy skeleton is featured with tight bone
  quality and rigid bones. While the bone density
  decreases, bone quality looks like alveolar and a
  lot of calcium is lost for the incidence of
  osteoporosis. Osteoporosis tends to cause ache at
  waist, back and limbs and deformed antisternum
  and always gives rise to fracture, disability so
  that induces or exacerbates original chronic
  diseases among elders. With very high lethality,
  complication as the result of fracture is one of
  main factors for the death of aged fracture
  patients.
• Instead of calcium renewal, the key for treatment
  is to inhibit the loss of bone matrix and improve
  the physical conditions for calcium absorption
  otherwise osteoporosis will be inevitable no
  matter how much calcium is taken due to the
  calcium absorbed from the external source is far
  below than that to be lost.

24

• c.
• Dysfunction of blood circulation at local joint
• For the inflammation of joint, local blood
  circulation may be damaged severely and local
  joint tissue may fail to get sufficient nutrients
  so that results in lower self repairing capacity.

25
Osteoarthritis undying cancer The most
important cause for decreased living quality of
elders 9 out of 10 elders are osteoarthritis
patients

• 360,000,000 people now surfers from arthritis
  all over the world.
• Since 40 for female and 50 for male,
• 55-60 is the highest incidence stage.
• The incidence rate among elders over 70
  approaches 90 per cent,
• which is far outweigh that of cardiovascular
  and cerebrovascular diseases
• Furthermore, the number of patients is
  increasing

26

• What shall be pointed out is that the
  incidence rate of osteoarthritis is much higher
  among female than among male, especially among
  female at pre- and post-pausimenia stage.
  According to statistics, women aged 45 is much
  likely to suffer from osteoarthritis therefore
  preventive measures shall be taken at about 35.

27

• Status of treatment for bone joint diseases
• The 1st Generation analgesia and
  anti-inflammation, symptomatic treatment
• 1. Physical treatment simple treatment methods,
  including traction, massage, acupuncture,
  infrared radiation and iontophoresis are applied
  however these methods can only alleviate the
  symptoms for a short while but fail to heal the
  articular cartilage.

28

• 2. Medicine treatment
• a. Oral medicine traditionally, non-steroidal
  anti-inflammatory and antalgesic drugs are used.
• It relives pain by inhibiting the process in
  which pain is generated. Although it demonstrates
  some advantages such as rapid pain killing
  effect, such method can only maintain a short
  while after stopping taking the drug because it
  only inhabits the symptoms of pain and fails to
  protect the articular cartilage. Some drugs would
  even accelerate the growth of osteoarthritis.

29

• For long-term use, some anti-inflammatory
  drugs such as indomethacin may cause serious side
  effects including nausea, vomiting, even gastric
  ulcer, gastrorrhagia and gastric perforation.
  Such drug may damage liver and kidney function,
  for example, causing acute renal failure and
  imparie the hematopoietic function of the body
  which results in dizziness, headache and
  neurological disorder or even causes necrosis of
  the femoral head.

30

• b. External medicine
• Clinically, a lot of external medicines
  including white and black salve mulls are used to
  treat arthritis. Commonly used Longhu Bone
  Strengthening Salve Mull and Musk Bone
  Strengthening Salve Mull etc. relive pain and
  improve local blood circulation effectively, but
  they tend to damage the skin and fail to repair
  cartilage fundamentally. Therefore, they cant be
  named ideal treatment methods.

31

• 3. Surgical therapy
• It is applicable to patients who have
  serious deformed joints or need to be replaced
  with artificial joints. Surgery brings patients
  with great pain and financial burden.
• Currently, it charges RMB 40,000-50,000 for
  replacing single side of knee joint and RMB
  80,000-100,000 for both sides. This brings great
  pain and financial burden to patients and their
  families.

32

• The 2nd Generation single ingredient,
  etiological treatment
• Glucosamine renewa
• Now, there are various glucosamine in
  markets. Most patients will change the brand of
  glucosamine after taking for a period of time if
  no decent effect is received. In most cases, the
  alternative one would fail to provide better
  effect. This is because that most oral
  glucosamine are single glucosamine which fail to
  renew bone and calcium fully.

33

• 2. Calcium renewal
• I always thought it would be rheumatism and
  cold when I was troubled with bad back and waist
  as well as cramp in legs. Now I know it is
  because of osteoporosis, I need to renew calcium
• The result of calcium renewal is continued
  osteoporosis and insufficient calcium, and still
  feeling tired to go up stairs

34
Is there any therapy which soothes symptoms and
tackles root causes so that relieves us from
troubles brought by osteoarthritis and
osteoporosis?
35

• It is the time to cure osteoarthritis
• with etiological treatment instead of symptomatic
  treatment

36
The 3rd Generation renewal bone and calcium,
etiological treatment
- repairs articular cartilage and inhibits
osteoporosis!
37
Ideal effect comes from perfect ingredients and
proportion
1.Glucosamine sulfate 2.Calcium
phosphate 3.Kudzuvine root extraction
38

• 1. Glucosamine (sulfate) repairs cartilage,
  lubricates joint
• Sales of glucosamine rank first among health
  keeping products in 7 consecutive years in the
  United States.
• Being approved by US FDA and EC, much more
  glucosamine is sold than calcium renewal
  products.
• Glucosamine is the only function food of
  which the popularization of curative effect is
  allowed by the government in Japan.
• It is widely acknowledged by middle ages and
  elders to renew calcium in China, but few of them
  know glucosamine renewal.

39
Glucosamine is a kind of mono aminosugar in
organisms, especially in articular cartilage. It
is the essential ingredient to compose
proteoglycan in articular mesochondrium of the
body. It is capable of inhibiting the
generation of superoxide radical that damages
cells, preventing the cartilage cells from being
damaged by cortical hormone and certain
non-steroidal anti-inflammatory medicines and
decreasing the release of endotoxin factors which
impairs cells soothing the pain of bone
joint, improving joint function and preventing
against the growth course of osteoarthritis and
promoting the generation of and renewing joint
fluid, keeping lubricating the articular
cartilage layer, reducing friction effect and
enabling the flexibility of joint. Glucosamine
controls over not only the bone joint health of
the body but also the metabolic balance of
articular cartilage and synovium.
40

• There are two kinds of glucosamine in current
  market, namely D-glucosamine hydrochloride and
  D-glucosamine sulphate.
• For treatment effect against arthritis,
  D-glucosamine hydrochloride receives general
  effect but produces considerable side effects,
  especially for patients with hyperpiesia,
  cardiovascular and cerebrovascular as well as
  kidney diseases
• while D-glucosamine sulphate receives better
  effect for reaching the nidus directly due to
  higher purity, smaller molecule and easier
  abosorption. The sylvine instead of sodium salt
  in D-glucosamine sulphate produces no side effect
  on patients with hyperpiesia, cardiovascular and
  cerebrovascular diseases, etc.
• Glucosamine is extracted from natural and organic
  raw materials, i.e. halobios in addition,
  glucosamine is a kind of intrinsic matter of the
  body, therefore it has no side effect on the
  body.

41

• 2. Calcium phosphate renewal of calcium and
  phosphorus, enhancing bone density
• Calcium renewal is the basic measure for any
  kind of osteoporosis. Calcium phosphate contains
  30-40 of calcium, which is beneficial for
  intestinal absorption.
• Renewal of calcium and phosphorus is
  particularly suitable for the status of middle
  ages and elders. Calcium phosphate renews calcium
  and phosphorus, prevents calcium and phosphorus
  against loss, and strengthens bone density.

42

• 3. Kudzuvine root extraction spasmolysis and
  dredge collaterals, promoting absorption

1. It is the absorptive accelerant for bone
joint and facilitates the absorption of
glucosamine and calcium. 2. It improves the
microcirculation in bone joint and increases
the supply of nutrition for abnormal cartilage
tissue. 3. It soothes pain effectively, and
relieves or prevents arthredema. It has decent
effects on decreasing lipid and pressure,
preventing thrombus, improving blood supply for
cardiac muscle, protecting against hearing loss
and promoting anamnesis, all of these are common
un-healthy states for middle ages and elders.
Therefore, it is characterized with multiple
functions, including repairing, protection,
treatment and prevention.
43
Kudzuvine root extraction contains a variety of
isoflavones so that works as the estrogen. Female
middle ages and elders are much likely to suffer
from insufficient calcium and osteoporosis for
loss of bone calcium due to decreased or
insufficient estrogen.
44
Laolaishou Glucosamine Kudzu and Calcium
Capsule consolidates the joint health
for you!
45

• 4-step Treatment with Glucosamine Kudzu and
  Calcium Capsule

46

• Step One Smooth
• Smoothes joint channel, dredges blood vessel,
  relieves spasm and improves blood circulation to
  ensure the smooth of blood stream and the
  nutrition supply for joint so that increases the
  support function of joint and relives pain.

47

• Step Two Elimination
• Eliminates enzyme, inflammation factor and
  free radical, etc. which damages cartilage from
  joint cavity, promotes metabolism of bone
  quality, inhibits damage against articular
  cartilage caused by free radical, and meanwhile,
  eliminates a large quantity of sodion, controls
  retention of water and sodium effectively and
  relieves or prevents arthredema.

48

• Step Three Renewal
• Renews glucosamine for cartilage and calcium
  for bone quality in time, promotes the absorption
  of glucosamine and calcium in joint under the
  effect of kudzuvine root to achieve etiological
  treatment as well as renewal of bone and calcium
  so that accelerates absorption. Joints are
  strengthened and enabled to move freely for the
  bone flexibility and stiffness is improved.

49

• Step Four Maintenance
• Balances the inner environment of joint
  cavity, lubricates joint, inhibits great loss of
  glucosamine and calcium, prevents the
  reoccurrence of pathological process and conducts
  comprehensive treatment so that enables the bone
  to be healthier and stronger and demonstrate
  vitality again.

50

• Clinical Verification of Glucosamine Kudzu
  and Calcium Capsule
• A. Significant effect on cartilage repairing
• Test for restoration of articular gap by
  comparing with placebo
• Test process
• Keep 211 osteoarthritis patients taking
  2.0g/day Glucosamine Kudzu and Calcium Capsule
  for three years and measure the articular gap of
  patients with x-ray (see the image right). It is
  found that the articluar gap is reduced from
  5.39mm to 5.18mm, while the articular gap of the
  comparison group is increased from 5.23mm to
  5.35mm.
• Conclusion the articular gap restores to
  the normal width and morning stiffness and pain
  disappear gradually after taking 2.0g/day
  Glucosamine Kudzuv and Calcium Capsule for three
  years.

51

• B. Antiphlogosis and odgnolysis, symptom soothing
  
• Pain relief test by comparing with
  non-steroidal anti-inflammatory medicine
  Ibuprofen
• Test process
• A random and dual-blind clinical study
  lasting for 6 weeks is conducted against 200
  patients suffering from osteoarthritis in the
  knee. Six weeks later, comparison is made between
  the group which takes Glucosamine Kudzu and
  Calcium Capsule 2,000mg/day and the group which
  takes non-steroidal anti-inflammatory medicine
  1,200mg/day.
• Conclusion the pain relief effect is
  identical for both groups after taking respective
  medicines for 4 weeks, but six weeks later, the
  pain relief effect of Glucosamine Kudzu and
  Calcium Capsule is obviously superior to that of
  Ibuprofen.

52

• C. Increasing bone calcium, improving
  osteoporosis
• Effect on thigh bone weight, calcium and
  density of rat by comparing with placebo and
  calcium carbonate
• Pharmacodynamic Research Report of Shanghai
  Institute of Preventive Medicine
• Effect of Glucosamine Kudzu and Calcium on
  thigh bone weight, calcium and density of rat
• Group(Cag/kg) Thigh
  bone weight Mid thigh bone density Calcium
  content
• Placebo
  0.800.03 a 0.1600.013 a
  208.517.68 a
• Calcium Carbonate
  0.850.03 b 0.2010.015 c
  252.813.30 b
• Glucosamine Kudzu and Calcium 0.850.03
  b 0.2080.014 c 258.97.47
  b
• It is demonstrated by the test data that
• glucosamine Kudzu and Calcium Capsule and
  calcium carbonate are significantly superior to
  placebo. plt0.05 means that both of them have
  remarkable curative effect on thigh bone weight,
  mid thigh bone density and calcium content.

53
?Suitable Population? 1. Population over 40 who
are desirable for health keeping and
osteoarthritis preventing 2. Middle ages and
elders who suffer leg cramp, fail to move freely
and stand immediately after sitting for a long
period of time, and feel tired for going up or
down stairs due to symptoms of degenerative joint
diseases, including joint swelling, stiffness and
pain and 3. Patients suffering from cervical
spondylosis, scapulohumeral periarthritis,
cheirarthritis, slipped disc, strain of lumbar
muscles, ankylosing spondylitis, sciatica,
rheumatic arthritis, arthritis deformans,
gonarthritis, hyperosteogeny, heel spur,
podarthritis, synovitis and peritendinitis etc.
Suits Middle Ages and Elders Best
54
Dosage Schedule of Laolaishou Glucosamine Kudzu
and Calcium Capsule
55

• Authoritative Certificate
• Scientific Verification
• Approved by the State Food and Drug
  Administration and granted with the national
  invention patent of China
• Approval No.G20080403 Patent No. ZL 2007
  1 0014511.9

56

• Shanghai Institute of Preventive Medicine
• Certification of Bone Density Function Test
• Certification of Toxicology Test
• Shandong Disease Control and Prevention Center
• Certification of Immunity Function Test

57

• Healthy waist, legs and limbs
• Flexible joints and ageless bones
• Bring vitality in old age

58
Thanks!