GRANULATION PROCESS

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Yashodhara bajaj college of pharmacy, chandrapur
Mr. M. M.Jeurkar
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Yashodhara bajaj college of pharmacy,
chandrapur GRANULATION PROCESS Guest Mr.
Maroti M Jeurkar Lecturer, YBCP, Chandrapur
-Mr. M. M.Jeurkar
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DEPARTMENTS 1.PRODUCTION -GRANULATION
-COMPRESSION -COATING
-INSPECTION -BLISTER PACKING 2.QUALITY
CONTROL DEP. 3.QUALITY ASSURANCE DEP.
-DOCUMENTATION -IPQA
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PRODUCTION DEPARTMENT (TABLET MFG)
PRODUCTION OFFICER OR MANAGER
R.M STORE
DAY STORE
GRANULATION
FIG Diagrammatically representation of material
issue from R.M store
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PRODUCTION DEPARTMENT
1.GRANULATION 2.COMPRESSION 3.COATING
4.INSPECTION
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• GRANULATION
• Granulation process has been widely used in the
  pharmaceutical industry for the preparation of
  material for tableting.
• It may be defined as a size enlargement process
  which converts fine or coarse particles into
  physically stronger and larger agglomerates
  having good flow property, better compression
  characteristic and uniformity.

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• NEED OF GRANULATION
• Increasing the compactness of a powder.
• Maintain the content uniformity of a product.
• Controlling the rate of drug release.
• Improving product appearance.
• TYPES OF GRANULATION
• 1.DRY GRANULATION
• 2.WET GRANULATION

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Rapid mixer granulation (R.M.G)
Fluidised bed Dryer
Vibro sifter
Vibro sifter
Co. mill
Vibro sifter
Conta blender
Granules Quarentine
Unloded material in Drum
FIG stepwise material load in granulation section
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Fig Vibro sifter
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Fig Rapid mixer granulation (R.M.G)
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Fig Fluidized bed dryer
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Fig Conta blender
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COMPRESSION
Compression it is external force (stress) that
trends to crush a material, squeezing its
particles closer and shortening the dimension in
the direction of its action.
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COATING
A coating is a covering that is applied to the
surface of an object, usually referred to as the
substrate. The purpose of applying the coating
may be decorative, functional, or both.
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INSPECTION Packing market
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2.QUALITY CONTROL DEP.
-Validation -stability
study -microbial study
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3.QUALITY ASSURANCE DEP.
-DOCUMENTATION -IPQA
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THANK YOU