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Title: Recombinant Protein Market Analysis | CMI

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  • Recombinant Protein Market, by Product Type
    (Hormones, Growth Factors, Cytokines, Plasma
    Protein Factor, Recombinant Metabolic Enzymes,
    Immune Checkpoint Regulators, and Others), By
    Application (Drug Discovery Development,
    Biopharmaceutical Production, Basic Research, and
    Others), By End User (Biopharmaceutical
    Companies, Academic Research Institutes,
    Contract Research Organizations, and Others), and
    Region - Global Industry insights, and Forecast
    till 2025
  • The global recombinant protein market was valued
    at US 347.2 million in 2016 and is expected to
    witness a robust CAGR of 6.2 over the forecast
    period (20172025).

Market Drivers
  • Increasing research development expenditure on
    biologic drugs is expected to boost demand for
    recombinant proteins for research purposes
  • Biopharmaceutical organizations are focusing on
    research and development of novel biosimilars for
    life threatening diseases such as cardiovascular
    diseases, cancer, metabolic disorders such as
    diabetes, and certain rare conditions such as
    hemophilia. According to Pharmaceutical Research
    and Manufacturers of America (PhRMA), 2016,
    member companies invested around US 58.8 billion
    in research and development in 2015, of which,
    majority was by all biopharmaceutical companies
    in the U.S. Rare disease medical space holds
    potential as there is relatively low competition.
    This is owing to less understanding of the
    disease progression pathways and entities.
    Therefore, companies could focus on RD for
    development of biologics and subsequently
    biosimilars in this space. Some of the
    biosimilars available in the market include
    Eprex, manufactured by Janssen-Cilag Pty Ltd.,
    which has been successful in treatment of anemia.
    Demand for biosimilars is increasing
    significantly, owing to high prices of biologics,
    in turn leading to high demand for recombinant

Figure 1. Global Recombinant Protein Market
Share, by Application () 2017 and 2025
  • Technological advancement in production of
    recombinant protein is expected to fuel growth of
    the Recombinant Protein Market
  • Advancement in technologies in various areas
    associated with or facilitating recombinant
    protein production have supported growth of
    recombinant protein market. For instance,
    development of alternative expression
    technologies such as mammalian cell expression,
    baculovirus expression, and E.coli expression,
    development of alternative cell lines, and
    enhanced cell culture systems have simplified and
    optimized recombinant protein processes.
    Furthermore, advanced chromatography protein
    purification methods such as FPLC and HPLC help
    in providing highly purified clinical grade
    recombinant proteins. Clustered regularly
    interspaced short palindromic repeats (CRISPR)
    technique is a genome editing technique used to
    target destruction in human cells and can improve
    recombinant protein production. Moreover,
    advancements in bioreactor systems have improved
    the products output within shorter time.
    According to National Centre for Biotechnology
    Information (NCBI), in 2014, about 65.6 of
    clinical scale manufacturers and 42 of
    commercial manufacturers adopted single use
    bioreactor for improvement in their

Market Restraints
  • Factors such as complex manufacturing process,
    high costs, and requirement of high quality of
    these products (responsible for high costs) are
    expected to hinder growth of the market over the
    forecast period.

Key Players
  • Some major players operating in the recombinant
    protein market include Crown Bioscience, Inc.,
    ProSpec Tany TechnoGene, Ltd., BPS Bioscience,
    Inc., Sigma Aldrich Company Ltd., Novoprotein
    Scientific, PeproTech, Inc., Feldan Bio, Inc.,
    BioVision, Inc., HumanZyme, Inc., and GenScript
    Biotech Corporation.

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