Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage

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Nimesulide Medicine -
Formulation, Properties, Clinical Study,
Benefits and Dosage
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Contents

• Introduction
• Chemical Formulation
• Properties of Nimesulide
• Clinical Study
• Benefits
• Dosage
• Conclusion
• Disclaimer

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Introduction

• Nimesulide ( Nise 100mg ) is
• an NSAID ( Non-steroidal Anti-inflammatory Drugs)
• a preferential COX II inhibitor
• a multi-factorial mode of action
• a analgesic drug
• a antipyretic drug

Fg.1 Nise 100 mg
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Chemical Formulation

• Chemical Formula C13H12N2O5S.
• Chemical Name 4-nitro-2-phenoxymethanesulfoanili
  de and
• belongs to BCS category II.
• exhibit low and variable oral bioavailability.
• may be a selective Cox-2 anti-inflammatory drug.
• by-product of p-nitrophenyl methane series sulfa.
  
• belongs to selective COX-2 inhibitors.

Fg.2Structure of Nimesulide
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Properties of Nimesulide

• 1.Pharmacokinetic
• acts as an aggressive inhibitor of histamine
  discharge in-vivo and in-vitro.
• antihistaminic and anti-allergic properties.
• Gastro-duodenal symptoms.
• beginning of pain relieving and antipyretic
  activity is 1.6 3.17 h and the term of activity
  is 10 12 h.
• 2. Absorption
• It is well absorbed from the GI tract following
  oral intake.
• 3. Pinnacle Plasma Levels
• PPL 1-3 hours.
• the study state is accomplished in 24 to 36
  hours ( Offer administrator of 100 mg).

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Clinical Study

• Nimesulide's remedial incentive in viable and
  quickly controlling aggravation and agony is
  bolstered by indispensable clinical proof.
• The drug prescribed is supposed to be suitable
  when the advantage can give to a specific patient
  exceed the dangers related to its utilization.
• Hence, a cautious examination of individual
  hazard factors is along these lines of urgent
  significance.

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Benefits of Nimesulide

• Nimesulide 100mg treats
• Headache, back pain, Sprains and strains.
• intense pain and primary dysmenorrhoea.
• fascinating results by acting quick and fast
  effects.
• No facet effects and gastro-duodenal symptoms.
• Rheumatic inflammatory disease, degenerative
  joint disease, alternative chronic joint
  disorders treatment.
• Musculoskeletal disorders, Thrombophlebitis and
  Cancer.
• Agonizing degenerative joint pains.

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Nimesulide Dosage

• Adults 100 mg twice daily after meals.
• Children 5 mg/kg of body weight in 2 or 3
  divided doses.
• The minimum effective dose should be used for the
  shortest duration to reduce the undesirable
  effects.
• The maximum duration of a treatment course with
  Nimesulide is 15 days.

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Conclusion

• Analgesics form a key part of a treatment, where
  pain and inflammation is experienced.
• Nimesulide well known for its analgesic or
  pain-relieving properties.
• Offers the aforementioned benefits and the drugs
  effectiveness.
• Therefore, Nimesulide is widely used to treat
  ailments causing acute pain.

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Disclaimer

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  informational purposes only. The Content is not
  intended to be a substitute for professional
  medical advice, diagnosis, or treatment. Always
  seek the advice of your physician or other
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  may have regarding a medical condition. Never
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