Host cell protein - PowerPoint PPT Presentation

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Host cell protein

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Host Cell Proteins (HCPs) are proteins produced or encoded by the host organisms that are used to produce biological products. Biological products, especially therapeutic proteins, are usually produced by genetically-modified prokaryotic or eukaryotic cells. – PowerPoint PPT presentation

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Title: Host cell protein


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host cell protein analysis
  • Host Cell Proteins (HCPs) are a heterogeneous,
    complex group of proteins that derived from the
    host cell. HCPs differ significantly in molecular
    mass, isoelectric point, hydrophobic properties,
    and structures. Figure 1 shows a harvested
    product pool of bacterial and mammalian
    fermentation by two-dimensional difference gel
    electrophoresis (2D-DIGE). Identification and
    quantification HCPs is very important in the
    development of biopharmaceutical products to
    ensure product purity and patient safety.
    Protease of HCPs can influence the protein
    pattern in culture and influence the purification
    process. In addition, HCPs can undergo
    post-translational modifications that make
    quantification and characterization more
    difficult. Moreover, high HCP variance results
    in different biochemical properties which could
    cause an immune response or allergic reactions
    even anaphylactic shock.

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Contact
  • Provider Creative Proteomics
  • URL http//www.creative-proteomics.com/services/h
    ost-cell-protein-analysis.htm
  • Email contact_at_creative-proteomics.com
  • Phone No. 1-631-619-7922
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