adc antibody - PowerPoint PPT Presentation

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adc antibody

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A variety of methodologies in ADC antibody design and engineering introduce a series of specific and chemically versatile conjugation sites into the antibody sequences, including incorporating Cysteine residues into defined sites on an antibody to create thiol-engineered antibody (EnCys-mAb) and conjugate payload drugs onto those Cysteine residues via thiol-based chemistry. – PowerPoint PPT presentation

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Date added: 19 February 2019
Slides: 9
Provided by: BellaSmith2018

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Title: adc antibody


1
Antibody Design and Conjugation
Reference https//www.creative-biolabs.com/adc/an
tibody-design-and-conjugation.htm
2
content
3
01
Intoduction of Antibody-drug conjugates
4
Antibody-drug conjugates
Introduction As one major component of an
antibody-drug conjugate (ADC), the antibody is
the key for target specificity and serves as the
cargo to deliver the cytotoxic drug (payload). A
payload drug can be attached to different sites
on an antibody using diverse conjugation
chemistry. Multiple endogenous amino acids can
serve as potential conjugation sites. However, to
achieve more precisely controlled site-directed
conjugations and subsequently a narrower
distribution of drug-to-antibody ratio (DAR),
special moieties with unique conjugation
chemistries are engineered into antibody
sequences in our antibody design services.
5
Some endogenous or engineered sites for the
conjugation of cytotoxic payload drugs to an
antibody (Antibodies,2015).
6
02
Methodologies in ADC antibody design and
engineering
7
Methodologies
8
Thanks
Reference https//www.creative-biolabs.com/adc/an
tibody-design-and-conjugation.htm
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