Vaccine In vivo assay

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Vaccine In Vivo Assay
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Background
In vivo assays play a crucial role in the
assessment of the potency and safety of human
vaccines. Efficient translation from basic
research to clinical therapies will depend on the
availability of appropriate animal models to
address every problem that arises during vaccine
development.
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Animal Models in Modern Vaccine Development
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Natural disease models
use specific pathogens and their native hosts to
model the interactions between hosts and
pathogens in the appropriate biological context.
This helps to understand the immunopathogenesis,
analyze the virulence factors and their roles in
invasion, penetration, and toxicity as well as
hosts immune responses to pathogens. In
addition, such models also allow the
identification of specific molecules which are
often required by the pathogen for infection or
subsequent disease induction, and which often
represent the targets for the host's immune
response.
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Animal Models in Modern Vaccine Development
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Surrogate models
provide a useful tool for studying specific
aspects of disease pathogenesis and host immune
response. Surrogate models use species that can
only be infected with the pathogen of interested
under experimental conditions. Therefore,
compromises often have to be made, such as higher
infection doses or artificial routes of
infection. In most cases, mice are chosen because
of their consistent genetic background, being
easy to operate and cost-effective.
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