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Bacterial expression System in Creative BioMart (2)

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Title: Bacterial expression System in Creative BioMart (2)


1
Bacterial expression System in Creative BioMart
2
  • Over the years, Creative BioMart has developed
    BacTECTM and FoldEZTM technologies to tackle
    hard-to-express and hard-to-dissolve proteins.
    With BacTECTM technology, the protein expression
    level can be greatly improved for almost all of
    the proteins. In addition, over 98 of the
    inclusion bodies can be refolded and solubilized
    by our proprietary FoldEZTM protein refolding
    technology.

3
Slide Title
  • Typically, the first choice for the expression of
    recombinant proteins is E. coli. Protein product
    in E. coli expression is fast, convinent,
    well-established and usually high yields.
  • Newly-built facilities supporting a vast array of
    state-of-the-art equipment are leveraged by our
    experienced PhD-level scientists to deliver
    proteins expressed via microbial systems quickly
    and economically.

4
  • One of the most popular technologies is BacTECTM
    system. Creative BioMart's patented BacTECTM
    system is capable of achieving high levels of
    soluble expression proteins. While the technology
    has shown it can express many types of proteins,
    it has established a track record for producing
    high-quality, correctly folded antibody fragments
    (including Fabs and scFv).

5
  • Our BacTECTM protein refolding technology is
    designed to determine the optimal refolding
    conditions by evaluation a series of buffers. We
    provide refolded protein at purity of 95 or
    greater.
  • Exclusively from Creative BioMart, OxiCytoTM
    competent E. coli strains are engineered to
    enable the folding of recombinantly expressed
    proteins in vivo. The expression of the
    isomerase, DsbC, within the OxiCyto cytoplasm
    enhances the correct formation of disulfide bonds
    in proteins that require them for biological
    activity.

6
  • Our Bacillus subtilis system is an ideal option
    for the expression of monomeric protein products
    at high expression levels. This high yield,
    combined with our patented fermentation protocols
    allow for fast process development and scale-up
    to support early clinical testing.

7
Contact Creative BioMart
  • Address 45-1 Ramsey Road Shirley, NY 11967, USA
  • Email contact_at_creative-biomart.com
  • Website http//www.creativebiomart.net
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