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anticarcinogenic properties of probiotics


health benefit of probiotics, how probiotics reduce the risk of colon cancer – PowerPoint PPT presentation

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Title: anticarcinogenic properties of probiotics

Anticarcinogenic properties of probiotics
  • Debika Roy
  • Department of Dairy Microbiology
  • Faculty of Dairy Technology

understanding the definitions
  • Prebiotic - (greek - before life) a substance
    (usually an oligosaccharide) that cannot be
    digested but does promote the growth of
    beneficial bacteria or probiotics.
  • Probiotic - (for life) a substance that contains
    microorganisms or bacteria that are beneficial to
    the host organism.
  • Symbiotic - (plus life) a substance containing
    both a prebiotic and probiotic.

What are Probiotics
  • Probiotic organisms are live microorganisms
    thought to be beneficial to the host organism.
    According to the currently adopted definition by
    FAO/WHO, probiotics are "Live microorganisms
    which when administered in adequate amounts
    confer a health benefit on the host". Lactic acid
    bacteria (LAB) and bifidobacteria are the most
    common types of microbes used as probiotics but
    certain yeasts and bacilli may also be used.

Probiotics microorganisms
  • Probiotics consist specific microbial cultures
    and/ or ingredients that stimulate gut micro
    flora capable of modifying the gastrointestinal
    environment which keeps the host healthy
  • Lactic acid producing bacteria
  • Lactobacilli and Bifidobacterium
  • Yeast
  • Others
  • Commercially available products may contain pure
    and combined cultures of
  • Lactobacillus
  • Bifidobacterium
  • Streptococcus
  • Pedicococcus
  • Aspergillus
  • Bacillus

Probiotics health benefits
Elimination of lactose intolerance Anti-diarrheal
Immunomodulatory Antidiabetic Anticarcinogenic
Hypocholesterolemic Antihypertensive
Probiotics and Cancer
  • Colorectal cancer represents a major public
    health problem accounting for over 1 million
    cases and about half a million deaths worldwide .
    Survival from colon cancer at 5 years has been
    found to vary demographically and estimated to be
    65 in North America, 54 in Western Europe, 34
    in Eastern Europe, and 30 in India.
  • Although chemotherapy and radiotherapy have been
    applied as the surgical adjuvant treatments of
    colon cancer, they vary in success rates for
    local recurrence, disease-free survival, and
    overall survival . In addition, these treatments
    may present some side effects such as an
    increased risk for infections, hair loss,
    fatigue, vomiting, diarrhea, and bloody stools.

Probiotics and Cancer
  • Diet interventions and natural bioactive
    supplements have now been extensively studied to
    reduce the risks of colon cancer, as a cause of
    prevention instead of cure. Postulated mechanisms
    include reduction in the activity of several
    cancer causing bacteria, desmutagenic and
    anticarcinogenic properties.
  • Prebiotics, being indigestible, have been
    associated with improved bowel functions and
    metabolisms of the distal colon, including a
    reduced risk of colon cancer.

Probiotics and Cancer
  • Enzymes (Glycosidase, B- glucuronidase ,
    azoreductase , and nitroreductase ) of the
    intestinal flora convert the precarcinogens to
    active carcinogens
  • Probiotics reduce
  • Faecal concentrations of enzymes
  • Secondary bile salts
  • Reduce absorption of harmful mutagens that may
    contribute to colon carcinogenesis.

Some proposed mechanisms
  • Several mechanisms have been proposed as to how
    lactic acid bacteria may inhibit colon cancer
  • Enhancing the hosts immune response
  • Altering the metabolic activity of the
    intestinal microflora
  • Binding and degrading carcinogens
  • Producing antimutagenic compounds
  • Altering the physiochemical conditions in the

Research on cancer still
The strongest evidence for the anti-cancer
effects of probiotics comes from animal studies
evidence from human studies (epidemiology and
experimental) is still limited. An important goal
for the future should be carefully designed human
clinical trials to corroborate the wealth of
experimental studies.
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