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Vitamin A Family

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Vitamin A Family. I am not responsible for errors ... Vitamin A is one of the more stable vitamins? False ... Bexarotene: Refractory cutaneous T cell lymphoma. ... – PowerPoint PPT presentation

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Title: Vitamin A Family


1
Vitamin A Family
  • I am not responsible for errors

2
  • What structure is the commercial forms of vitamin
    A.

3
  • Retinol
  • Retinol Acetate
  • Retinol Palmitate

4
  • What is the RDA for men of vitamin A?

5
  • Men 900 µg/day
  • Women 700 µg/day

6
  • True or False
  • Vitamin A is one of the more stable vitamins?

7
  • False
  • Vitamin A is one of the more unstable vitamins
  • Sensitve to
  • ACID
  • O2
  • UV

8
  • T or F
  • Vitamin A is stored in the liver for 2 months.

9
  • False
  • Vitamin A is stored in the liver for 6-9 months.

10
  • What is the most serious deficiency of vitamin A?

11
  • Some evidence that the vitamin affects certain
    aminoacyl tRNA synthetase enzymes needed for
    glycoproteins found in mucous. Specific mucous
    glycoproteins are missing in vitamin A deficient
    individuals.
  • For adults this is the most serious form of the
    deficiency because the mucous layer forms one of
    the physical barriers to microbial infection. A
    Vitamin A deficient individual can die from
    infection.

12
  • What pigments are considered the provitamins of
    vitamin A?

13
  • Carotenes are the yellow/orange pigments which
    can be considered the provitamin A.

14
  • True or False
  • Vitamin A esters are more readily absorbed in the
    intestine than carotenes

15
  • True
  • Vitamin A esters are more readily absorbed in the
    intestine than carotenes

16
  • If retinol is the commercial form of vitamin A,
    how would you increase intestinal absorption in
    the mucosa lining?

17
  • You could administer retinol palmitate. This way
    it would go straight to the chylomicrons and
    finally to the liver to meet
  • Enzymes
  • 1. esterases
  • 2. oxidation

18
Acute Hypervitaminosis
  • What are the symptoms of acute hypervitaminosis
    of vitamin A?

19
  • Hannahs Headache
  • VD (is) Vertigo/Diarrhea
  • Very Vomiting
  • Nasty Nausea

20
  • True or False
  • Vitamin A is tetratogenic?

21
  • True

22
  • The visual pigment in the rods is known as
    _________.

23
  • Rhodopsin

24
  • Rhodopsin is formed from what?

25
  • Opsin
  • 11-cis retinal

26
  • ______________ is the most tragic aspect of
    vitamin A deficiency. (Causes blindness). There
    are 3 10 million children with this condition.

27
  • Xerophthalmia
  • Xer
  • oph
  • thalmia

28
  • What is the receptor for vitamin A?

29
  • Retinal Binding protein.

30
  • Why do patients with kwashiorkor and other
    protein malnutrition states have very low serum
    vitamin A levels?

31
  • There is a deficiency of the amino acids
    necessary to produce the retinal binding protein.

32
  • __________ results from delayed accommodation
    time. A deficiency of vitamin A means that there
    will be a lack of retinal to combine with the
    opsin.

33
  • Night Blindness
  • Results from delayed accommodation time. A
    deficiency of vitamin A means that there will be
    a lack of retinal to combine with the opsin.

34
Vitamin A
  • Non-vitamin drug uses?

35
  • Bexarotene Refractory cutaneous T cell lymphoma.
  • Tretinoin increasing the turnover of follicular
    epithelial cells and decreasing the cohesiveness
    of follicular epithelial cells.
  • Isotretinoin (accutane) acne ?
  • Adapalene binds to the retinoic acid nuclear
    receptor that modulates cell differentiation,
    keratinization and inflammatory responses.

36
What am I
37
  • Retinal Used in Vision

38
What am I?
39
  • Retinoic Acid used in cell differentiation.

40
What am I
41
  • Retinol inactive commercial form.

42
Who am I?
43
  • ?-carotene

44
What Am I?
45
  • a-carotene

46
Who am I?
47
  • ß-carotene

48
  • Your friend saw on Oprah that Vitamin A is now
    bad for a developing fetus. What would be the
    result of severely limiting the amount a
    developing fetus receives? (Yeah its a bad
    question but what the hell)

49
  • Retinoic acid now is considered a hormone that
    plays a pivotal role in cell differentiation in
    embryos.

50
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