Genetic Analysis of Small Sample Size

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Genetic Analysis of Small Sample Size
Larry J. Wangh Laboratory
Laboratory of Human Genetics and Reproductive
Biology Brandeis University, Waltham,
Massachusetts
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The Research Challenge
Genetic Analysis of Small Sample Numbers
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Analytical Tools for Small Sample Size
Applications
Reaction Methods
Sample Preparation
Product Analysis
Infectious Disease
Detection of Multiple Products
Quantitative End-Point Analysis
Forensics
SampleLyse
Cancer Detection Analysis
Single Tube Sequencing
RT cDNA
PurAmp
SNP Genotyping
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Analytical Tools for Small Sample Size
Applications
Reaction Methods
Sample Preparation
Product Analysis
Infectious Disease
Detection of Multiple Products
Quantitative End-Point Analysis
Forensics
QuantiLyse
Cancer Detection Analysis
Single Tube Sequencing
RT cDNA
PurAmp
SNP Genotyping
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Analytical Tools for Small Sample Size
Applications
Reaction Methods
Sample Preparation
Product Analysis
Infectious Disease
Low-Tm Probes
Quantitative End-Point Genotyping
Forensics
QuantiLyse
Cancer Detection Analysis
Single Tube Sequencing
RT cDNA
PurAmp
SNP Genotyping
6
Analytical Tools for Small Sample Size
Reaction Methods
Sample Preparation
Product Analysis
Low-Tm Probes
Quantitative End-Point Genotyping
QuantiLyse
Single Tube Sequencing
RT cDNA
PurAmp
7
Analytical Tools for Small Sample Size
Applications
Reaction Methods
Sample Preparation
Product Analysis
Infectious Disease
Detection of Multiple Products
Quantitative End-Point Genotyping
Forensics
Cancer Detection Analysis
Single Tube Sequencing
RT cDNA
SNP Genotyping
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Human Genetic Diagnosis Projects

• Biomarker Detection in Human Cancers

Esophageal Adenocarcinoma
Normal Esophagus

• Detection of Chromosome 21 Trisomies (Down
  Syndrome)

Normal Chr. 21
Triploid Chr. 21
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Basic Biology Projects

• Analysis of Gene Expression in Single Mouse
  Blastomeres

• Molecular Signatures for Bacterial Strain
  Identification

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Technology Development Projects

• Mechanism of Suppression of PCR Products Errors

• Development of New Hybridization Probe Designs

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Genetic Analysis of Small Sample Size
Larry J. Wangh Laboratory
Bassine 127 Same Floor as the Biology Office