Patho??

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Patho??

• ???
• 2005/11/10
• Add on by 2008/4/23

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Alzheimer's Disease
In the neuropil of the cerebral cortex there is
fragmentation of neurites (neuronal processes)
within gray matter producing the characteristic
"senile plaques." These are degenerative
presynaptic endings. The plaques may also contain
a few astrocytes, and microglia. Bielschowsky
silver stain, microscopic.
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Alzheimer's Disease
The thioflavin stain viewed with fluorescence
microscopy highlights the neuritic plaques of
Alzheimer's disease with amyloid deposition which
fluoresces bright green, as shown here.
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Alzheimer's Disease
Alzheimer's disease, senile plaque. Older plaques
contain a central amyloid core, seen here with
Congo red stain, microscopic.
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Alzheimer's Disease
Alzheimer's disease, neurofibrillary tangle. The
neurons demonstrate intracytoplasmic
proliferation of twisted filaments producing the
visible "neurofibrillary tangle" under the
microscope. These are commonly found in the
pyramidal cells of the Hippocampus and the
cerebral cortex. H and E stain, microscopic.
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Alzheimer's Disease
Alzheimer's disease, neurofibrillary tangle. The
tangles are best demonstrated with Bielschowsky
silver stain as shown here, microscopic.
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Lewy Body Diseases
At the left, an HE stain demonstrates a rounded
pink cytoplasmic Lewy body in a neuron of the
cerebral cortex from a patient with diffuse Lewy
body disease, which can be a cause for dementia.
Lewy bodies can also be seen in substantia nigra
with Parkinson's disease. An immunoperoxidase
stain for ubiquitin, seen at the right, helps
demonstrate the Lewy bodies more readily by the
brown reaction product within them.
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Lewy body
Intracytoplasmic argyrophilic round inclusions
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Lewy bodies
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CADASI(GOM)
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Creutzfeldt-Jakob Disease
A few small vacuoles are seen in the gray matter
of a patient with CJD of rapid onset and short
duration.
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Creutzfeldt-Jakob Disease
An area of vacuoles that are coalescing to
microcysts are seen in the gray matter of a
patient with CJD of more prolonged duration.
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Creutzfeldt-Jakob Disease
At medium power, there are numerous gray matter
vacuoles, along with gliosis and neuronal loss,
in a patient with advanced CJD.
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Varient CJD
Note the rounded dark pink plaques, surrounded by
prominent spongiform change, that are features of
variant CJD.
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Fibromuscular dysplasia
The wall of this intramyocardial coronary artery
is thickened and the lumen is narrowed due to
abundant deranged muscle and fibrous tissue.
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string of beads ? ?????
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Lafora body
Round, homogeneous intracytoplasmic inclusions.
PAS() ?????hereditary myoclonic epilepsy
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Bunina body
ALS, non specific ???? Intracytoplasmic,
eosinophilic inclusions
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Bunina bodies(in lower motor neurons of ALS)

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Pick disease(FTD)

• Pathologically characterized by knife blade
  atrophy of the frontal and temporal lobes.

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Pick body
Intracytoplasmic neuronal argyrophilic round
inclusions. Pick's disease with numerous
argyrophilic PICK BODIES (PB). Note the PB are
homogeneous, smooth-edged, and intensely
argyrophilic.
Such structures are easily distinguished from
ALZHEIMER NEUROFIBRILLARY TANGLES (NFT) using the
same stain. NFT are more often flame-shaped, have
distinct filamentous substructure with irregular
edges and lucencies within them, and exhibit
variable staining intensity with silver
(argyrophilia).
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Pick bodies

• Very marked neuronal loss and gliosis in areas
  with ballooned neurons and intracytoplasmic Pick
  bodies.

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Negri body
???Rabies. ??irregular, intensely eosinophilic,
intracytoplasmic inclusions.
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Cowdry A inclusion
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Rosenthal fiber

• Round, elongaged, eosinophilic struture produced
  by atrocytes