Biophotonics at the Visual Optics Laboratory and at the University of Ottawa

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Biophotonics at the Visual Optics Laboratory and
at the University of Ottawa

• Rejean Munger, PhD
• C. G. and L.J Wood Chair for Vision Research
• Visual Optics Laboratory, U. Otttawa Eye
  Institute
• Associate Director, CRP

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Tissue health monitoring

• Tissue optical properties Diagnostics
• Colour
• Intensity
• Pattern
• Objective, fast, reliable, inexpensive and
  noninvasive assessment of biological systems
• Multiple markets

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Transparency Instrument
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Transparency vs Chemical Wound
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Recovery Evaluation
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Example 2 IOL Glistening
Transparency
Backscatter
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Optical properties assessment

• Detection 2 change in transparency, scatter
  (forward, backward) and specular reflection
• Application
• Pre transplant assessment of tissue
• Replacement of animal testing in ocular
  sensitivity testing
• Expandable to other tissues
• Early cataract detection

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Refractive Surgery Planning
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Refractive Surgery Planning
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Wavefront sensing limitations

• Wavelength
• Coherence effects (double pass)
• Scaling between astronomical and ocular
  applications
• Is wavefront actual perfect correction?

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Wavefront sensing limitations
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Wavefront based PRK / LASIK
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The anatomically based eye model
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The Refractive Workstation
Custom eye model
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Adaptive optics visual performance

• Correct the ocular aberrations Measure ocular
  performance
• Introduce know aberrations Measure ocular
  performance
• Map out impact of aberrations on vision
• Develop Robust corrections
• Not optimal but very good over a range of
  conditions
• Maybe even with age related changes

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Future?
On the possibility of intraocular adaptive
optics Gleb Vdovin, Electronic Instrumentation,
TU Delft, OKO Technologies Mikhail Loktev,
Electronic Instrumentation, TU Delft, Alexander
Naumov, P.N. Lebedev Physical Institute
Abstract We consider the technical possibility
of an adaptive contact lens and an adaptive eye
lens implant based on the modal
liquidcrystal wavefront corrector, aimed to
correct the accommodation loss and higher-order
aberrations of the human eye. Our .rst
demonstrator with 5 mm optical aperture is
capable of changing the focusing power in the
range of 0 to 3 diopters and can be controlled
via a wireless capacitive link. These properties
make the corrector potentially suitable for
implantation into the human eye or for use as an
adaptive contact lens. We also discuss possible
feedback strategies, aimed to improve visual
acuity and to achieve supernormal vision with
implantable adaptive optics.
7 April 2003 / Vol. 11, No. 7 / OPTICS EXPRESS 815
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Concept - OKO
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Biophotonics at U. Ottawa

• Rejean Munger, PhD
• C. G. and L.J Wood Chair for Vision Research
• Visual Optics Laboratory
• Associate Director, CRP

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Biophotonics

• Focus Develop photonics into the tool of choice
  for interacting with biological systems from the
  molecular to the macroscopic regime
• Emphasis
• Autonomous non-invasive diagnostic
• High throughput screening (toxic agents and
  pathogens)
• Treatments (manipulation at the cellular level)

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Biophotonics
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Bioactive materials
Matrix based on biomaterial
Single species targeting agent
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Other bio-sensing structures

• Zyolite nano structures
• Fibre based sensing
• Etc

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Biophotonics lanscape
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Why Ottawa?

• Devices design group
• Polymer chemistry
• Canadian Photonics Fabrication Centre
• Ophthalmic expertise
• Fundamental photonics program (lasers, light
  controlled chemistry, molecular cooling, etc )
• Newly formed Centre for Pervasive Photonics
  Research